Effect of aqueous extracts of several kinds of herbs on human platelet aggregation and expression of P-selectin in vitro

Ling-geng Yan; Jun-shan Ruan; Lei Zhang; Fang-tian Fan; Feng Zhang; Ai-yun Wang; Shi-zhong Zheng; Li Zeng; Wen-lin Li; Yin Lu

doi:10.1007/s11655-013-1540-5

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Effect of aqueous extracts of several kinds of herbs on human platelet aggregation and expression of P-selectin in vitro

OriginalPaper | Updated：2021-08-27

- Effect of aqueous extracts of several kinds of herbs on human platelet aggregation and expression of P-selectin in vitro
- Effect of aqueous extracts of several kinds of herbs on human platelet aggregation and expression of P-selectin in vitro
- 中国结合医学杂志（英文版） 2015年21卷第4期页码：286-290
- Affiliations：
  
  1. Department of Clinical Pharmacy, College of Pharmacy, Nanjing University of Chinese Medicine,Nanjing,China
  2. Library of Nanjing University of Chinese Medicine,Nanjing,China
  3. Fujian Provincial Hospital, Clinical College of Fujian Medical University,Fuzhou,China
- Author bio：
- Funds：
  
  These authors contributed equally to this work;Supported by the National Natural Science Foundation of China (No. 30371727 and 30772766), Natural Science Foundation of Jiangsu Province (No. BK2007239), and Educational Commission of Jiangsu Province (No. 09KJA360002)
- DOI：10.1007/s11655-013-1540-5
  中图分类号：
- 纸质出版日期：2015，
  
  网络出版日期：2014-1-28，
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Yan, Lg., Ruan, Js., Zhang, L. et al. Effect of aqueous extracts of several kinds of herbs on human platelet aggregation and expression of P-selectin in vitro, ., Chin. J. Integr. Med. 21, 286–290 (2015). https://doi.org/10.1007/s11655-013-1540-5

Ling-geng Yan, Jun-shan Ruan, Lei Zhang, et al. Effect of aqueous extracts of several kinds of herbs on human platelet aggregation and expression of P-selectin in vitro[J]. Chinese Journal of Integrative Medicine, 2015,21(4):286-290.
Yan, Lg., Ruan, Js., Zhang, L. et al. Effect of aqueous extracts of several kinds of herbs on human platelet aggregation and expression of P-selectin in vitro, ., Chin. J. Integr. Med. 21, 286–290 (2015). https://doi.org/10.1007/s11655-013-1540-5 DOI：

Ling-geng Yan, Jun-shan Ruan, Lei Zhang, et al. Effect of aqueous extracts of several kinds of herbs on human platelet aggregation and expression of P-selectin in vitro[J]. Chinese Journal of Integrative Medicine, 2015,21(4):286-290. DOI： 10.1007/s11655-013-1540-5.

摘要

To study the effect of aqueous extract of several kinds of herbs on human platelet aggregation and expression of P-selectin in vitro. Blood was collected from volunteers. Effects of the prepared water extracts of herbs on platelet aggregation were monitored on a Packs-4 aggregometer. The fluorescence intensity of water extracts of Caulis Spatholobi

Flos Carthami and Rhizoma Curcumae on the expression of P-selectin in human platelets of healthy persons was measured with flow cytometry. Out of several herbs investigated

Flos Carthami and Rhizoma Curcumae potently inhibited platelet aggregation after incubation with platelet-rich plasma (PRP) for 15 min. Caulis Spatholobi Flos Carthami and Rhizoma Curcumae inhibited adenosine-5′-diphosphate (ADP) or platelet activating factor (PAF)-induced platelet aggregation in PRP in a dose-dependent manner. In contrast to Flos Carthami and Rhizoma Curcumae

Caulis Spatholobi could not inhibit thrombin-induced platelet aggregation. Despite its inability to inhibit thrombin-induced platelet aggregation in PRP

Caulis Spatholobi had a greater anti-aggregating activity in PRP induced by ADP or PAF. Caulis Spatholobi and Flos Carthami showed significant inhibitory effects on the expression of P-selectin. Caulis Spatholobi

Flos Carthami and Rhizoma Curcumae have potent anti-platelet properties

and their inhibitory actions are mediated via different mechanisms. Caulis Spatholobi inhibited ADP-induced platelet aggregation but not by thrombin

indicating that its mechanism of action might be independent of the thromboxane pathway. The effect of Caulis Spatholobi and Flos Carthami were associated with suppressing the expression of P-selectin.

Abstract

Flos Carthami and Rhizoma Curcumae on the expression of P-selectin in human platelets of healthy persons was measured with flow cytometry. Out of several herbs investigated

Caulis Spatholobi could not inhibit thrombin-induced platelet aggregation. Despite its inability to inhibit thrombin-induced platelet aggregation in PRP

Flos Carthami and Rhizoma Curcumae have potent anti-platelet properties

and their inhibitory actions are mediated via different mechanisms. Caulis Spatholobi inhibited ADP-induced platelet aggregation but not by thrombin

关键词

plateletsherbsPlatelet AggregationCaulis SpatholobiFlos CarthamiRhizoma Curcumaeplatelet-rich plasmaP-selectin

Keywords

plateletsherbsPlatelet AggregationCaulis SpatholobiFlos CarthamiRhizoma Curcumaeplatelet-rich plasmaP-selectin

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