Guo, Zj., Li, Cs. Therapeutic effects of shenfu injection (参附注射液) on post-cardiac arrest syndrome., Chin. J. Integr. Med. 19, 716–720 (2013). https://doi.org/10.1007/s11655-013-1566-8
Zhi-jun Guo, Chun-sheng Li. Therapeutic effects of shenfu injection (参附注射液) on post-cardiac arrest syndrome[J]. Chinese Journal of Integrative Medicine, 2013,19(9):716-720.
Guo, Zj., Li, Cs. Therapeutic effects of shenfu injection (参附注射液) on post-cardiac arrest syndrome., Chin. J. Integr. Med. 19, 716–720 (2013). https://doi.org/10.1007/s11655-013-1566-8DOI:
Zhi-jun Guo, Chun-sheng Li. Therapeutic effects of shenfu injection (参附注射液) on post-cardiac arrest syndrome[J]. Chinese Journal of Integrative Medicine, 2013,19(9):716-720. DOI: 10.1007/s11655-013-1566-8.
Therapeutic effects of shenfu injection (参附注射液) on post-cardiac arrest syndrome
摘要
Survival rates after cardiac arrest have not changed substantially over the past 5 decades. Postcardiac arrest (CA) syndrome (PCAS) is the primary reason for the high mortality rate after successful restoration of spontaneous circulation (ROSC). Intravenous administration of Shenfu Injection (参附注射液
SFI) may attenuate post-CA myocardial dysfunction and cerebral injury
inhibit systemic ischemia/reperfusion responses
and treat underlying diseases. In this article
we reviewed the therapeutic effects of SFI in PCAS. SFI might be useful in the treatment of PCAS
incorporating the multi-link and multi-target advantages of Chinese medicine into PCAS management. Further experimental and clinical research to verify the therapeutic effects of SFI in PCAS is required.
Abstract
Survival rates after cardiac arrest have not changed substantially over the past 5 decades. Postcardiac arrest (CA) syndrome (PCAS) is the primary reason for the high mortality rate after successful restoration of spontaneous circulation (ROSC). Intravenous administration of Shenfu Injection (参附注射液
SFI) may attenuate post-CA myocardial dysfunction and cerebral injury
inhibit systemic ischemia/reperfusion responses
and treat underlying diseases. In this article
we reviewed the therapeutic effects of SFI in PCAS. SFI might be useful in the treatment of PCAS
incorporating the multi-link and multi-target advantages of Chinese medicine into PCAS management. Further experimental and clinical research to verify the therapeutic effects of SFI in PCAS is required.
Chiota NA, Freeman WD, Barrett KM. Hypoxic-ischemic brain injury and prognosis after cardiac arrest. Continuum (Minneap minn) 2011;17:1094–1118.
Curfman GD. Hypothermia to protect the brain. N Engl J Med 2002;346:546.
Nichol G, Thomas E, Callaway CW, Hedges J, Powell JL, Aufderheide TP, et al. Regional variation in out-ofhospital cardiac arrest incidence and outcome. JAMA 2008;300:1423–1431.
Neumar RW, Nolan JP, Adrie C, Aibiki M, Berg RA, Bottiger BW, et al. Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication: a consensus statement from the International Liaison Committee on Resuscitation. Circulation 2008;118:2452–2483.
Chen JH, Chen LF, Mei GY, eds. Modern emergency internal medicine of traditional Chinese medicine. 1st ed. Guangdong: Guangdong Science and Technology Press; 1996:138–144.
Chen GT, Yang SS, eds. Practical diagnostics and therapeutics of integrated traditional Chinese and Western medicine. 1st ed. Beijing: Chinese Medical Science and Technology Press; 1991:41–45.
Li Q, Li BZ, Liu H. Pharmacological action and clinical application of Shenfu injection. Med Recapitul (Chin) 2008;14:1247–1250.
Zheng SD, Wu HJ, Wu DL. Roles and mechanisms of ginseng in protecting heart. Chin J Integr Med 2012;18:548–555.
Michael JR, Guerci AD, Koehler RC, Shi AY, Tsitlik J, Chandra N, et al. Mechanisms by which epinephrine augments cerebral and myocardial perfusion during cardiopulmonary resuscitation in dogs. Circulation 1984;69:822–835.
Ditchey RV, Lindenfeld J. Failure of epinephrine to improve the balance between myocardial oxygen supply and demand during closed-chest resuscitation in dogs. Circulation 1988;78:382–389.
Ji XF, Wang S, Yang L, Li CS. Impaired beta-adrenergic receptor signaling in post-resuscitation myocardial dysfunction. Resuscitation 2012;83:640–644.
Jacobs IG, Finn JC, Jelinek GA, Oxer HF, Thompson PL. Effect of adrenaline on survival in out-of-hospital cardiac arrest: a randomized double-blind placebo-controlled trial. Resuscitation 2011;82:1138–1143.
Zhang YJ, He MF, Liu SH, Xu WC, Wei H, Tao J, et al. Effects of Shenfu injection on restoration of spontaneous circulation in a rabbit model of cardiac arrest. J Emerg Tradit Chin Med (Chin) 2005;14:460–461.
Liu YQ. Effects of Shenfu injection on successful rates of cardiopulmonary-cerebral resuscitation. Liaoning J Tradit Chin Med (Chin) 2005;32:445–446.
Hsu CY, Huang CH, Chang WT, Chen HW, Cheng HJ, Tsai MS, et al. Cardioprotective effect of therapeutic hypothermia for postresuscitation myocardial dysfunction. Shock 2009;32:210–216.
Kern KB, Zuercher M, Cragun D, Ly S, Quash J, Bhartia S, et al. Myocardial microcirculatory dysfunction after prolonged ventricular fibrillation and resuscitation. Crit Care Med 2008;36:418–421.
Guo ZJ, Li CS, Yin WP, Hou XM, Gu W, Zhang D. Comparison of shock-first strategy and cardiopulmonary resuscitation-first strategy in a porcine model of prolonged cardiac arrest. Resuscitation. Available at: http://dx.doi.org/10.1016/j.resuscitation. Accessed June 21, 2012
Kern KB, Hilwig RW, Rhee KH, Berg RA. Myocardial dysfunction following resuscitation from cardiac arrest: an example of global myocardial stunning. J Am Coll Cardiol 1996;28:232–240.
Gu W, Li CS, Yin WP, Guo ZJ, Hou XM, Zhang D. Shenfu injection reduces postresuscitation myocardial dysfunction in a porcine model of cardiac arrest by modulating apoptosis. Shock 2012;38:301–306.
Ji XF, Yang L, Zhang MY, Li CS, Wang S, Cong LH. Shenfu injection attenuates postresuscitation myocardial dysfunction in a porcine model of cardiac arrest. Shock 2011;35:530–536.
Li ZP, Chen SQ, Zhang J, Chen JY, Huang WJ, Wang WT, et al. Protective effect of different doses of Shenfu injection on myocardial injury after cardiopulmonary resuscitation in rats. Chin J Integr Tradit West Med Intens Crit Care (Chin) 2007;14:162–165.
Hammel JM, Caldarone CA, Van Natta TL, Wang LX, Welke KF, Li W, et al. Myocardial apoptosis after cardioplegic arrest in the neonatal lamb. J Thorac Cardiovasc Surg 2003;125:1268–1275.
Caldarone CA, Barner EW, Wang L, Karimi M, Mascio CE, Hammel JM, et al. Apoptosis-related mitochondrial dysfunction in the early postoperative neonatal lamb heart. Ann Thorac Surg 2004;78:948–955.
Shi ZM, Gu GG, Wu GZ, He JJ, Yang XY, Li RD. Study on the protective effects of Shenfu injection on myocardial cells in rats after cardiopulmonary resuscitation. J Clin Emerg Call (Chin) 2005;6:16–19.
Hirsch KG, Koenig MA, Geocadin RG. Management of brain injury after cardiac arrest. Continuum Lifelong Learning Neurol 2009;15:100–120.
Zhang J, Chen SQ, Li ZP, Huang WJ, Chen JY, Zhang HX, et al. Influence of Shenfu injection on cerebral edema and expression of S100β protein after cardiopulmonary resuscitation in rats. Zhejiang Med J (Chin) 2007;29:440–444.
Chen SQ, Li ZP, Zhang J, Wang WT, Huang WJ, Chen JY, et al. Influence of Shenfu injection on change of neuronspecific enolase in rats after cardiopulmonary resuscitation. Chin J Emerg Med (Chin) 2008;17:167–172.
Gu GG, Lin ZF, Yang XY, Li RD. Study on the protective effects of Shenfu injection on neurocyte in rats after cardiopulmonary resuscitation. J Intern Med Concept Pract (Chin) 2010;5:68–72.
Adams JA. Endothelium and cardiopulmonary resuscitation. Crit Care Med 2006;34:458–465.
Esmon CT. Coagulation and inflammation. J Endotoxin Res 2003;9:192–198.
Zheng SY, Sun J, Zhao X, Xu JG. Protective effect of Shenfu on myocardial ischemia-reperfusion injury in rats. Am J Chin Med 2004;32:209–220.
He YH, Chen C, Xia ZY. Mechanism of protective effect of Shenfu injection on renal failure induced by intestinal ischemia-reperfusion in rats. Chin J Integr Tradit West Med Intens Crit Care (Chin) 2008;15:67–70.
Huikuri HV, Castellanos A, Myerburg RJ. Sudden death due to cardiac arrhythmias. N Engl J Med 2001;345:1473–1482.
Davies MJ, Thomas A. Thrombosis and acute coronaryartery lesions in sudden cardiac ischemic death. N Engl J Med 1984;310:1137–1140.
Yin WP, Li CS. Effect of Shen-Fu injection on hemodynamics and oxygen delivery metabolism in dogs with cardiogenic shock. Chin J Integr Tradit West Med Intens Crit Care (Chin) 2008;15:20–23.
Zhang N, Qiu ZL, Ye YP, Xu JL, Lou TZ, Lei HX. Influence of Shenfu injection on inflammatory cytokines and prognosis in patients with severe sepsis. Chin Arch Tradit Chin Med (Chin) 2011;29:525–527.
Liu MY, Chen KJ. Convergence: the tradition and the modern. Chin J Integr Med 2012;18:164–165.
Neuroprotective effect of Shenfu Injection (参附注射液) following cardiac arrest in pig correlates with improved mitochondrial function and cerebral glucose uptake
Shenfu Injection (参附注射液) inhibits inflammation in patients with acute myocardial infarction complicated by cardiac shock
Effects of Shenfu Injection (参附注射液) on cerebral metabolism in a porcine model of cardiac arrest
Shen-Fu Injection (参附注射液) alleviates post-resuscitation myocardial dysfunction by up-regulating expression of sarcoplasmic reticulum Ca2+-ATPase
Comparison of Shenfu Injection (参附注射液) and epinephrine on catecholamine levels in a porcine model of prolonged cardiac arrest
相关作者
暂无数据
相关机构
Department of Hyperbaric Oxygen, Beijing Chao-Yang Hospital, Capital Medical University
Department of Emergency, Beijing Chao-Yang Hospital, Capital Medical University
Emergency and Critical Care Center, Beijing Anzhen Hospital, Capital Medical University
Department of Emergency, the First Affiliated Hospital of Nanchang University
Department of Emergency, Beijing Chaoyang Hospital, Capital Medical University, Beijing Key Laboratory of Cardiopulmonarycerebral Resuscitation