Liuwei Dihuang Pills (六味地黄丸) enhance the effect of Western medicine in treating type 2 diabetes: A meta-analysis of randomized controlled trials

Run Pu; Xiang-nan Geng; Fei Yu; Hui-gang Liang; Lu-wen Shi

doi:10.1007/s11655-013-1591-7

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Liuwei Dihuang Pills (六味地黄丸) enhance the effect of Western medicine in treating type 2 diabetes: A meta-analysis of randomized controlled trials

OriginalPaper | Updated：2021-08-27

- Liuwei Dihuang Pills (六味地黄丸) enhance the effect of Western medicine in treating type 2 diabetes: A meta-analysis of randomized controlled trials
- Liuwei Dihuang Pills (六味地黄丸) enhance the effect of Western medicine in treating type 2 diabetes: A meta-analysis of randomized controlled trials
- 中国结合医学杂志（英文版） 2013年19卷第10期页码：783-791
- Affiliations：
  
  1. Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University Health Science Center,Beijing,China
  2. Chinese Pharmaceutical Association,Beijing,China
  3. Peking University First Hospital,Beijing,China
  4. Center for Healthcare Management Systems, East Carolina University,Greenville,USA
- Author bio：
- Funds：
  
  Supported by the National Key Technology Research and Development Program of the People’s Republic of China (No. 2009BAI76B030900)
- DOI：10.1007/s11655-013-1591-7
  中图分类号：
- 纸质出版日期：2013，
  
  网络出版日期：2013-10-4，
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Pu, R., Geng, Xn., Yu, F. et al. Liuwei Dihuang Pills (六味地黄丸) enhance the effect of Western medicine in treating type 2 diabetes: A meta-analysis of randomized controlled trials., Chin. J. Integr. Med. 19, 783–791 (2013). https://doi.org/10.1007/s11655-013-1591-7

Run Pu, Xiang-nan Geng, Fei Yu, et al. Liuwei Dihuang Pills (六味地黄丸) enhance the effect of Western medicine in treating type 2 diabetes: A meta-analysis of randomized controlled trials[J]. Chinese Journal of Integrative Medicine, 2013,19(10):783-791.
Pu, R., Geng, Xn., Yu, F. et al. Liuwei Dihuang Pills (六味地黄丸) enhance the effect of Western medicine in treating type 2 diabetes: A meta-analysis of randomized controlled trials., Chin. J. Integr. Med. 19, 783–791 (2013). https://doi.org/10.1007/s11655-013-1591-7 DOI：

Run Pu, Xiang-nan Geng, Fei Yu, et al. Liuwei Dihuang Pills (六味地黄丸) enhance the effect of Western medicine in treating type 2 diabetes: A meta-analysis of randomized controlled trials[J]. Chinese Journal of Integrative Medicine, 2013,19(10):783-791. DOI： 10.1007/s11655-013-1591-7.

摘要

To perform meta-analyses evaluating the efficacy of adding Liuwei Dihuang Pills (六味地黄丸

LDP) to Western medicine in improving treatment outcomes for type 2 diabetes. Medline

PubMed

Cochrane Library

and Chinese databases

including the Chinese National Knowledge Infrastructure were searched to identify eligible studies; i.e.

if the study involved a randomized clinical trial in which the experimental group combined LDP with Western drugs and the control group used the corresponding Western drugs alone to treat type 2 diabetes. Outcomes were measured in terms of fasting blood glucose (FBG)

postprandial blood glucose (2hPG) and HbA1c level. Efficacy was also measured by using control and response rates. The combined odds ratio (OR)

mean difference (MD)

and 95% confidence intervals (95% CI) were calculated. Studies included in the analysis were less adequate than expected in terms of methodological quality. A total of 1

609 patients from 18 studies were included. We found that adding LDP can lower patients’ FBG (MD=0.54 mmol/L

95% CI [0.15

0.93]

P=0.007)

2hPG (MD=1.05 mmol/L

95% CI [0.29

1.81]

P<0.01) and HbA1c (MD=0.23

95% CI [0.02

0.45]

P=0.008). There were also improvements in treatment response rates (OR=3.41

95% CI [2.38

4.90]

P<0.01) and control rates (OR=2.47

95% CI [1.91

3.20]

P<0.01). Adding LDP to Western medicine might improve treatment outcomes of diabetes

including FBG

2hPG

response rates and control rates.

Abstract

To perform meta-analyses evaluating the efficacy of adding Liuwei Dihuang Pills (六味地黄丸

LDP) to Western medicine in improving treatment outcomes for type 2 diabetes. Medline

PubMed

Cochrane Library

and Chinese databases

including the Chinese National Knowledge Infrastructure were searched to identify eligible studies; i.e.

postprandial blood glucose (2hPG) and HbA1c level. Efficacy was also measured by using control and response rates. The combined odds ratio (OR)

mean difference (MD)

and 95% confidence intervals (95% CI) were calculated. Studies included in the analysis were less adequate than expected in terms of methodological quality. A total of 1

609 patients from 18 studies were included. We found that adding LDP can lower patients’ FBG (MD=0.54 mmol/L

95% CI [0.15

0.93]

P=0.007)

2hPG (MD=1.05 mmol/L

95% CI [0.29

1.81]

P<0.01) and HbA1c (MD=0.23

95% CI [0.02

0.45]

P=0.008). There were also improvements in treatment response rates (OR=3.41

95% CI [2.38

4.90]

P<0.01) and control rates (OR=2.47

95% CI [1.91

3.20]

P<0.01). Adding LDP to Western medicine might improve treatment outcomes of diabetes

including FBG

2hPG

response rates and control rates.

关键词

meta-analysesLiuwei Dihuang Pillstype 2 diabetesFasting Blood Glucosepostprandial blood glucosehemoglobin A1c

Keywords

meta-analysesLiuwei Dihuang Pillstype 2 diabetesFasting Blood Glucosepostprandial blood glucosehemoglobin A1c

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