Effects of Fengbaisan (丰白散) on the expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in lung tissue of rats with chronic obstructive pulmonary disease

Yu Wang; Nan-xiang Su; Ze-qi Chen; Zhe Wang; Si-fang Zhang

doi:10.1007/s11655-013-1619-z

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Effects of Fengbaisan (丰白散) on the expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in lung tissue of rats with chronic obstructive pulmonary disease

OriginalPaper | Updated：2021-08-27

- Effects of Fengbaisan (丰白散) on the expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in lung tissue of rats with chronic obstructive pulmonary disease
- Effects of Fengbaisan (丰白散) on the expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in lung tissue of rats with chronic obstructive pulmonary disease
- 中国结合医学杂志（英文版） 2014年20卷第3期页码：224-231
- Affiliations：
  
  1. Department of Traditional Chinese Medicine, the 2nd Xiangya Hospital, Central South University,Hunan,Changsha,China
  2. Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University,Hunan,Changsha,China
- Author bio：
- Funds：
  
  Supported by the Scientific Research Foundation of Traditional Chinese Medicine of Hunan Provincial Health Bureau (No. 201194);the General Science and Technology Project of Hunan Provincial Science and Technology Bureau (No. 2011SK3232)
- DOI：10.1007/s11655-013-1619-z
  中图分类号：
- 纸质出版日期：2014，
  
  网络出版日期：2013-11-16，
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Wang, Y., Su, Nx., Chen, Zq. et al. Effects of Fengbaisan (丰白散) on the expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in lung tissue of rats with chronic obstructive pulmonary disease., Chin. J. Integr. Med. 20, 224–231 (2014). https://doi.org/10.1007/s11655-013-1619-z

Yu Wang, Nan-xiang Su, Ze-qi Chen, et al. Effects of Fengbaisan (丰白散) on the expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in lung tissue of rats with chronic obstructive pulmonary disease[J]. Chinese Journal of Integrative Medicine, 2014,20(3):224-231.
Wang, Y., Su, Nx., Chen, Zq. et al. Effects of Fengbaisan (丰白散) on the expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in lung tissue of rats with chronic obstructive pulmonary disease., Chin. J. Integr. Med. 20, 224–231 (2014). https://doi.org/10.1007/s11655-013-1619-z DOI：

Yu Wang, Nan-xiang Su, Ze-qi Chen, et al. Effects of Fengbaisan (丰白散) on the expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in lung tissue of rats with chronic obstructive pulmonary disease[J]. Chinese Journal of Integrative Medicine, 2014,20(3):224-231. DOI： 10.1007/s11655-013-1619-z.

摘要

To observe effects of Fengbaisan (丰白散

FBS) on the expression of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in lung tissue of rats with chronic obstructive pulmonary disease (COPD) and to investigate the preventive and therapeutic mechanisms of FBS. The COPD rat model was established by cigarette smoke exposure and lipopolysaccharide (LPS) intra-tracheal dripping. The histopathological changes of lung tissue was observed via hematoxylin/eosin staining. The expression of MMP-9 and TIMP-1 in lung tissue was measured by reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry. The typical histopathological changes of COPD were displayed in the model group

Ambroxol Hydrochloride group and FBS group

and the pathological lesions in the FBS group were less than those in the model group. The expression of MMP-9 and TIMP-1 in the model group increased significantly compared with those in the normal group (P<0.05). After treatment for successive 28 days

the expression of MMP-9 and TIMP-1 in the FBS group decreased remarkably as compared with the model group (P<0.05). FBS can regulate MMP-9/TIMP-1 imbalance to prevent airway and lung parenchyma remodeling process via reducing the expression of MMP-9 and TIMP-1 in the lung tissue of COPD rats

and this may be a possible therapeutic mechanism of FBS on COPD.

Abstract

To observe effects of Fengbaisan (丰白散

Ambroxol Hydrochloride group and FBS group

and this may be a possible therapeutic mechanism of FBS on COPD.

关键词

Chronic Obstructive Pulmonary DiseaseFengbaisanmatrix metalloproteinase-9tissue inhibitor of metalloproteinase-1airway remodelingChinese Medicine

Keywords

Chronic Obstructive Pulmonary DiseaseFengbaisanmatrix metalloproteinase-9tissue inhibitor of metalloproteinase-1airway remodelingChinese Medicine

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