How does Chinese medicine target cytokine imbalance in rheumatoid arthritis?

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How does Chinese medicine target cytokine imbalance in rheumatoid arthritis?

ReviewPaper | Updated：2021-08-27

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- How does Chinese medicine target cytokine imbalance in rheumatoid arthritis?
- How does Chinese medicine target cytokine imbalance in rheumatoid arthritis?
- 中国结合医学杂志（英文版） 2013年19卷第11期页码：874-880
- Affiliations：
  
  1. Department of Rheumatism Immunity, First Affiliated Hospital, Anhui University of Chinese Medicine,Hefei,China
  2. Anhui University of Chinese Medicine,Hefei,China
- Author bio：
- Funds：
  
  Supported by the Key Projects in the National Science and Technology Pillar Program during the Twelfth Five-Year Plan Period (No. 2012BAI26B02);the National Key Disciplines of Chinese Medicine Construction Projects (No. [2009]30);Anhui Technology Scientific Research and Development Program of Provincial Department (No. 11010402170);Technology Innovation Team Program of Anhui University of Chinese Medicine (No. 2010TD005)
- DOI：10.1007/s11655-013-1620-6
  中图分类号：
- 纸质出版日期：2013，
  
  网络出版日期：2013-10-30，
Scan for full text
Liu, J., Sun, Y. How does Chinese medicine target cytokine imbalance in rheumatoid arthritis?., Chin. J. Integr. Med. 19, 874–880 (2013). https://doi.org/10.1007/s11655-013-1620-6

Jian Liu, Yue Sun. How does Chinese medicine target cytokine imbalance in rheumatoid arthritis?[J]. Chinese Journal of Integrative Medicine, 2013,19(11):874-880.
Liu, J., Sun, Y. How does Chinese medicine target cytokine imbalance in rheumatoid arthritis?., Chin. J. Integr. Med. 19, 874–880 (2013). https://doi.org/10.1007/s11655-013-1620-6 DOI：

Jian Liu, Yue Sun. How does Chinese medicine target cytokine imbalance in rheumatoid arthritis?[J]. Chinese Journal of Integrative Medicine, 2013,19(11):874-880. DOI： 10.1007/s11655-013-1620-6.

摘要

Rheumatoid arthritis (RA) manifests as an imbalance between pro- and anti-inflammatory cytokines. Cytokine imbalance is suggested to play critical roles in the development of RA. Currently

various treatments for RA

including biological agents such as antibodies against inflammation mediators

or Chinese herbal medicines

intervene the disease by restoring the balance of cytokines. Chinese medicine (CM) can not only suppress the expression of pro-inflammatory cytokines

but also induce the expression of cytokines with anti-inflammatory and immunomodulatory effects. Thus

Chinese medicine can effectively reduce inflammatory cell infiltration into synovial tissue

pannus formation

and degradation of the extracellular matrix surrounding cartilage cells

thereby reducing subchondral bone damage. This paper reviews the changes of cytokine profiling during development of RA and discuss the mechanisms by which Chinese medicine restores the cytokine balance.

Abstract

Rheumatoid arthritis (RA) manifests as an imbalance between pro- and anti-inflammatory cytokines. Cytokine imbalance is suggested to play critical roles in the development of RA. Currently

various treatments for RA

including biological agents such as antibodies against inflammation mediators

or Chinese herbal medicines

intervene the disease by restoring the balance of cytokines. Chinese medicine (CM) can not only suppress the expression of pro-inflammatory cytokines

but also induce the expression of cytokines with anti-inflammatory and immunomodulatory effects. Thus

Chinese medicine can effectively reduce inflammatory cell infiltration into synovial tissue

pannus formation

and degradation of the extracellular matrix surrounding cartilage cells

thereby reducing subchondral bone damage. This paper reviews the changes of cytokine profiling during development of RA and discuss the mechanisms by which Chinese medicine restores the cytokine balance.

关键词

rheumatoid arthritiscytokine imbalanceChinese Medicine

Keywords

rheumatoid arthritiscytokine imbalanceChinese Medicine

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School of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine

Department of Rheumatology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences

Department of Radiology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences

Department of Radiology, Beijing Union Hospital

Department of Rheumatology, The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine

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