Hericium erinaceus (Bull.: Fr.) Pers., a medicinal mushroom, activates peripheral nerve regeneration

Kah-Hui Wong; Gowri Kanagasabapathy; Murali Naidu; Pamela David; Vikineswary Sabaratnam

doi:10.1007/s11655-014-1624-2

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Hericium erinaceus (Bull.: Fr.) Pers., a medicinal mushroom, activates peripheral nerve regeneration

OriginalPaper | Updated：2021-08-27

- Hericium erinaceus (Bull.: Fr.) Pers., a medicinal mushroom, activates peripheral nerve regeneration
- Hericium erinaceus (Bull.: Fr.) Pers., a medicinal mushroom, activates peripheral nerve regeneration
- 中国结合医学杂志（英文版） 2016年22卷第10期页码：759-767
- Affiliations：
  
  1. Department of Anatomy, Faculty of Medicine, University of Malaya,Kuala Lumpur,Malaysia
  2. Mushroom Research Centre, University of Malaya,Kuala Lumpur,Malaysia
  3. Institute of Biological Sciences, Faculty of Science, University of Malaya,Kuala Lumpur,Malaysia
- Author bio：
- Funds：
  
  Supported by the High Impact Research Grant and Fundamental Research Grant Scheme FP023/2008C of University of Malaya
- DOI：10.1007/s11655-014-1624-2
  中图分类号：
- 纸质出版日期：2016，
  
  网络出版日期：2014-8-26，
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Wong, KH., Kanagasabapathy, G., Naidu, M. et al. , Hericium erinaceus (Bull.: Fr.) Pers., a medicinal mushroom, activates peripheral nerve regeneration., Chin. J. Integr. Med. 22, 759–767 (2016). https://doi.org/10.1007/s11655-014-1624-2

Kah-Hui Wong, Gowri Kanagasabapathy, Murali Naidu, et al. Hericium erinaceus (Bull.: Fr.) Pers., a medicinal mushroom, activates peripheral nerve regeneration[J]. Chinese Journal of Integrative Medicine, 2016,22(10):759-767.
Wong, KH., Kanagasabapathy, G., Naidu, M. et al. , Hericium erinaceus (Bull.: Fr.) Pers., a medicinal mushroom, activates peripheral nerve regeneration., Chin. J. Integr. Med. 22, 759–767 (2016). https://doi.org/10.1007/s11655-014-1624-2 DOI：

Kah-Hui Wong, Gowri Kanagasabapathy, Murali Naidu, et al. Hericium erinaceus (Bull.: Fr.) Pers., a medicinal mushroom, activates peripheral nerve regeneration[J]. Chinese Journal of Integrative Medicine, 2016,22(10):759-767. DOI： 10.1007/s11655-014-1624-2.

摘要

To study the ability of aqueous extract of Hericium erinaceus mushroom in the treatment of nerve injury following peroneal nerve crush in Sprague-Dawley rats. Aqueous extract of Hericium erinaceus was given by daily oral administration following peroneal nerve crush injury in Sprague-Dawley rats. The expression of protein kinase B (Akt) and mitogen-activated protein kinase (MAPK) signaling pathways; and c-Jun and c-Fos genes were studied in dorsal root ganglia (DRG) whereas the activity of protein synthesis was assessed in peroneal nerves by immunohistochemical method. Peripheral nerve injury leads to changes at the axonal site of injury and remotely located DRG containing cell bodies of sensory afferent neurons. Immunofluorescence studies showed that DRG neurons ipsilateral to the crush injury in rats of treated groups expressed higher immunoreactivities for Akt

MAPK

c-Jun and c-Fos as compared with negative control group (P <0.05). The intensity of nuclear ribonucleoprotein in the distal segments of crushed nerves of treated groups was significantly higher than in the negative control group (P <0.05). H. erinaceus is capable of promoting peripheral nerve regeneration after injury. Potential signaling pathways include Akt

MAPK

c-Jun

and c-Fos

and protein synthesis have been shown to be involved in its action.

Abstract

MAPK

c-Jun

and c-Fos

and protein synthesis have been shown to be involved in its action.

关键词

Hericium erinaceusdorsal root gangliasignaling pathwaysgene expressionprotein synthesis machineryperipheral nerve regeneration

Keywords

Hericium erinaceusdorsal root gangliasignaling pathwaysgene expressionprotein synthesis machineryperipheral nerve regeneration

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