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Two sets of acupoint combination of similar functions engage shared neural representation: A functional magnetic resonance imaging study
Two sets of acupoint combination of similar functions engage shared neural representation: A functional magnetic resonance imaging study
- 中国结合医学杂志（英文版） 2014年20卷第3期 页码：184-193
- Affiliations：
1. College of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine,Chengdu,China
2. Life Sciences Research Center, School of Life Sciences and Technology, Xidian University,Xi’an,China
3. The Third Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine,Hangzhou,China
4. The Teaching Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu,China
- Author bio：
- Funds：Supported by the Project for the National Basic Research Program of China (973 Program, No. 2012CB518501), the National Natural Science Foundation of China (No. 30901900, 30930112, and 81101108), the Project of Administration of Traditional Chinese Medicine of Sichuan Province (No. 2012-E-038), and the Project of Innovative Research Team Research Fund of Sichuan Provincial Education Department (No.12TD002)
DOI：10.1007/s11655-014-1744-3
中图分类号：纸质出版日期：2014，
网络出版日期：2014-3-4，
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Zhao, L., Qin, W., Liu, Jx. et al. Two sets of acupoint combination of similar functions engage shared neural representation: A functional magnetic resonance imaging study., Chin. J. Integr. Med. 20, 184–193 (2014). https://doi.org/10.1007/s11655-014-1744-3
Ling Zhao, Wei Qin, Ji-xin Liu, et al. Two sets of acupoint combination of similar functions engage shared neural representation: A functional magnetic resonance imaging study[J]. Chinese Journal of Integrative Medicine, 2014,20(3):184-193.
Zhao, L., Qin, W., Liu, Jx. et al. Two sets of acupoint combination of similar functions engage shared neural representation: A functional magnetic resonance imaging study., Chin. J. Integr. Med. 20, 184–193 (2014). https://doi.org/10.1007/s11655-014-1744-3 DOI：
Ling Zhao, Wei Qin, Ji-xin Liu, et al. Two sets of acupoint combination of similar functions engage shared neural representation: A functional magnetic resonance imaging study[J]. Chinese Journal of Integrative Medicine, 2014,20(3):184-193. DOI： 10.1007/s11655-014-1744-3.
摘要
To investigate whether the neural representations underlying alternating two acupoint combinations (ACs) are the same or not. In this functional magnetic resonance imaging study
two sets of analgesia ACs were utilized
including Waiguan (TE5) and Qiuxu (GB40) for Group A
and Neiguan (PC6) and Taichong (LR3) for Group B
which are the most commonly adopted in clinical treatment. Each group had 20 healthy subjects. An experimental design was proposed
which consisted of a pre-needling resting phase
a needling phase and a post-needling resting phase. This paradigm optimally mimics the clinical protocol as well as focuses on both the stimulation and the resting periods. The results were subjected to general linear model analysis
conjunction analysis and the functional connectivity analysis. The rostral anterior cingulated cortex was engaged in the initiative period of the acupuncture effect in both groups
and it was chosen as the seed region for the functional connectivity analysis for the following resting period. The results showed that several shared brain regions were involved in both groups
in particular the insula
amygdala and hypothalamus. Moreover
significant differences were located at the posterior cingulated cortex as revealed by a two sample -test (P<0.05
corrected). Other regions showed no significant differences. This finding was further supported by the spatial correlation analysis that the two groups were significantly correlated (r =0.51
P<0.01). This preliminary research helps us understand the neurophysiological mechanisms of acupuncture when following clinical guidelines on ACs
as well as provides an important opportunity to develop better treatment strategies for reducing
or even preventing pain.
Abstract
To investigate whether the neural representations underlying alternating two acupoint combinations (ACs) are the same or not. In this functional magnetic resonance imaging study
two sets of analgesia ACs were utilized
including Waiguan (TE5) and Qiuxu (GB40) for Group A
and Neiguan (PC6) and Taichong (LR3) for Group B
which are the most commonly adopted in clinical treatment. Each group had 20 healthy subjects. An experimental design was proposed
which consisted of a pre-needling resting phase
a needling phase and a post-needling resting phase. This paradigm optimally mimics the clinical protocol as well as focuses on both the stimulation and the resting periods. The results were subjected to general linear model analysis
conjunction analysis and the functional connectivity analysis. The rostral anterior cingulated cortex was engaged in the initiative period of the acupuncture effect in both groups
and it was chosen as the seed region for the functional connectivity analysis for the following resting period. The results showed that several shared brain regions were involved in both groups
in particular the insula
amygdala and hypothalamus. Moreover
significant differences were located at the posterior cingulated cortex as revealed by a two sample -test (P<0.05
corrected). Other regions showed no significant differences. This finding was further supported by the spatial correlation analysis that the two groups were significantly correlated (r =0.51
P<0.01). This preliminary research helps us understand the neurophysiological mechanisms of acupuncture when following clinical guidelines on ACs
as well as provides an important opportunity to develop better treatment strategies for reducing
or even preventing pain.
关键词
acupoint combinationAcupuncture Analgesiafunctional magnetic resonance imaging
Keywords
acupoint combinationAcupuncture Analgesiafunctional magnetic resonance imaging
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