Therapeutic effect of dimethyl dimethoxy biphenyl dicarboxylate on collagen-induced arthritis in rats

Roba M. Talaat; Amira S. Abo-El-Atta; Sabah M. Farou; Karima I. El-Dosoky

doi:10.1007/s11655-014-1746-1

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Therapeutic effect of dimethyl dimethoxy biphenyl dicarboxylate on collagen-induced arthritis in rats

OriginalPaper | Updated：2021-08-27

- Therapeutic effect of dimethyl dimethoxy biphenyl dicarboxylate on collagen-induced arthritis in rats
- Therapeutic effect of dimethyl dimethoxy biphenyl dicarboxylate on collagen-induced arthritis in rats
- 中国结合医学杂志（英文版） 2015年21卷第11期页码：846-854
- Affiliations：
  
  1. Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute, Menofia University, Sadat Branch, Sadat,Egypt
  2. Pathology Department, Faculty of Medicine, Tanta University, Tanta,Egypt
- Author bio：
- Funds：
- DOI：10.1007/s11655-014-1746-1
  中图分类号：
- 纸质出版日期：2015，
  
  网络出版日期：2014-3-2，
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Talaat, R.M., Abo-El-Atta, A.S., Farou, S.M. et al. Therapeutic effect of dimethyl dimethoxy biphenyl dicarboxylate on collagen-induced arthritis in rats., Chin. J. Integr. Med. 21, 846–854 (2015). https://doi.org/10.1007/s11655-014-1746-1

Roba M. Talaat, Amira S. Abo-El-Atta, Sabah M. Farou, et al. Therapeutic effect of dimethyl dimethoxy biphenyl dicarboxylate on collagen-induced arthritis in rats[J]. Chinese Journal of Integrative Medicine, 2015,21(11):846-854.
Talaat, R.M., Abo-El-Atta, A.S., Farou, S.M. et al. Therapeutic effect of dimethyl dimethoxy biphenyl dicarboxylate on collagen-induced arthritis in rats., Chin. J. Integr. Med. 21, 846–854 (2015). https://doi.org/10.1007/s11655-014-1746-1 DOI：

Roba M. Talaat, Amira S. Abo-El-Atta, Sabah M. Farou, et al. Therapeutic effect of dimethyl dimethoxy biphenyl dicarboxylate on collagen-induced arthritis in rats[J]. Chinese Journal of Integrative Medicine, 2015,21(11):846-854. DOI： 10.1007/s11655-014-1746-1.

摘要

To study the effect of oral administration of dimethyl dimethoxy biphenyl dicarboxylate (DDB) on adjusting angiogeneic/inflflammatory mediators and ameliorating the pathology of bones in rats with collagen-induced arthritis (CIA). Wistar rat model of CIA was set up using bovine collagen type II. Fifty rats were divided into fifive groups randomly: normal

CIA model

DDB treatment

methotrexate (MTX) treatment

and combined DDB+MTX treatment. Ankle joints of rats were imaged with digital X-ray machine to show the destruction of joints. Fore and hind paw and knee joints were removed above the ankle joint then processed for haematoxylin and eosin staining. Plasma levels of vascular endothelial growth factor (VEGF)

platelet derived growth factor

interleukin-8 (IL-8)

IL-4

tumor necrosis factor α (TNF-α)

and cyclooxygenase-2 (COX-2) were quantifified by enzyme-linked immunosorbent assay. Nitric oxide levels were detected by Griess reagent. Compared with the CIA model group

a remarkable reduction in various angiogenic (VEGF and IL-8) and inflflammatory mediators (TNF-α

IL-4 and COX-2) after treatment with DDB either alone or combined with MTX P<0.05 or P<0.01). Histopathological and X-ray fifindings were confifirmatory to the observed DDB anti-arthritic effect. The DDB-treated group showed amelioration in signs of arthritis which appeared essentially similar to normal. Our data shed light on the therapeutic effificacy of DDB in experimental rheumatoid arthritis (RA) compared with a choice drug (MTX) and it may be offered as a second-line drug in the treatment of RA.

Abstract

CIA model

DDB treatment

methotrexate (MTX) treatment

platelet derived growth factor

interleukin-8 (IL-8)

IL-4

tumor necrosis factor α (TNF-α)

and cyclooxygenase-2 (COX-2) were quantifified by enzyme-linked immunosorbent assay. Nitric oxide levels were detected by Griess reagent. Compared with the CIA model group

a remarkable reduction in various angiogenic (VEGF and IL-8) and inflflammatory mediators (TNF-α

关键词

rheumatoid arthritiscollagen-induced arthritisdimethyl dimethoxy biphenyl dicarboxylateangiogenesisinflflammation

Keywords

rheumatoid arthritiscollagen-induced arthritisdimethyl dimethoxy biphenyl dicarboxylateangiogenesisinflflammation

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