Protective effects of Jiashen Prescription (加参方) on myocardial infarction in rats

Ming-jun Zhu; You-ping Wang; Shi-yang Xie; Wei-hong Liu; Bin Li; Yong-xia Wang; He Wang; Bo-li Zhang

doi:10.1007/s11655-014-1751-4

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Protective effects of Jiashen Prescription (加参方) on myocardial infarction in rats

OriginalPaper | Updated：2021-08-27

- Protective effects of Jiashen Prescription (加参方) on myocardial infarction in rats
- Protective effects of Jiashen Prescription (加参方) on myocardial infarction in rats
- 中国结合医学杂志（英文版） 2015年21卷第6期页码：417-422
- Affiliations：
  
  1. Division of Cardiology and Central Laboratory, First Affiliated Hospital, Henan University of Traditional Chinese Medicine,Zhengzhou,China
  2. Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine,Tianjin,China
- Author bio：
- Funds：
  
  Supported by National Natural Science Foundation of China (No. 81173410 )
- DOI：10.1007/s11655-014-1751-4
  中图分类号：
- 纸质出版日期：2015，
  
  网络出版日期：2014-5-10，
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Zhu, Mj., Wang, Yp., Xie, Sy. et al. Protective effects of Jiashen Prescription (加参方) on myocardial infarction in rats., Chin. J. Integr. Med. 21, 417–422 (2015). https://doi.org/10.1007/s11655-014-1751-4

Ming-jun Zhu, You-ping Wang, Shi-yang Xie, et al. Protective effects of Jiashen Prescription (加参方) on myocardial infarction in rats[J]. Chinese Journal of Integrative Medicine, 2015,21(6):417-422.
Zhu, Mj., Wang, Yp., Xie, Sy. et al. Protective effects of Jiashen Prescription (加参方) on myocardial infarction in rats., Chin. J. Integr. Med. 21, 417–422 (2015). https://doi.org/10.1007/s11655-014-1751-4 DOI：

Ming-jun Zhu, You-ping Wang, Shi-yang Xie, et al. Protective effects of Jiashen Prescription (加参方) on myocardial infarction in rats[J]. Chinese Journal of Integrative Medicine, 2015,21(6):417-422. DOI： 10.1007/s11655-014-1751-4.

摘要

To evaluate the effects of Jiashen Prescription (加参方

JSP) on myocardial infarction (MI) size and cardiac function at the early stage of MI in rats. One hundred male Sprague-Dawley rats were subjected to sham-operation or MI induced by ligating the left anterior descending coronary artery. The rats with MI were treated with vehicle

JSP 3 and 6 g/(kg·d)

or losartan 10 mg/(kg·d) for 1 week. Compared with the vehicle-treated MI rats

6 g/(kg·d) JSP reduced MI size 3 days after MI (P<0.05)

and attenuated the MI-induced increases in left ventricular end-diastolic and end-systolic dimension and decreases in fractional shortening and ejection fraction 1 week after MI (P<0.05). In addition

6 g/(kg·d) JSP and losartan were equally effective in reducing MI size and enhancing cardiac functional recovery. JSP reduces MI size and improves cardiac function after MI

suggesting that JSP has potential as a therapy for MI.

Abstract

To evaluate the effects of Jiashen Prescription (加参方

JSP 3 and 6 g/(kg·d)

or losartan 10 mg/(kg·d) for 1 week. Compared with the vehicle-treated MI rats

6 g/(kg·d) JSP reduced MI size 3 days after MI (P<0.05)

and attenuated the MI-induced increases in left ventricular end-diastolic and end-systolic dimension and decreases in fractional shortening and ejection fraction 1 week after MI (P<0.05). In addition

6 g/(kg·d) JSP and losartan were equally effective in reducing MI size and enhancing cardiac functional recovery. JSP reduces MI size and improves cardiac function after MI

suggesting that JSP has potential as a therapy for MI.

关键词

Jiashen Prescriptionmyocardial infarctioncardiac functionChinese Medicine

Keywords

Jiashen Prescriptionmyocardial infarctioncardiac functionChinese Medicine

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