Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: A randomized clinical trial

Samira Pourmoradian; Reza Mahdavi; Majid Mobasseri; Elnaz Faramarzi; Mehrnoosh Mobasseri

doi:10.1007/s11655-014-1804-8

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Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: A randomized clinical trial

OriginalPaper | Updated：2021-08-27

- Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: A randomized clinical trial
- Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: A randomized clinical trial
- 中国结合医学杂志（英文版） 2014年20卷第5期页码：347-352
- Affiliations：
  
  1. Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz,Iran
  2. Endocrinology Department of Medicine Faculty, Tabriz University of Medical Sciences, Tabriz,Iran
  3. Student Research Committee, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz,Iran
  4. Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz,Iran
- Author bio：
- Funds：
  
  Support by the Nutrition Research Center, Tabriz University of Medical Sciences
- DOI：10.1007/s11655-014-1804-8
  中图分类号：
- 纸质出版日期：2014，
  
  网络出版日期：2014-3-7，
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Pourmoradian, S., Mahdavi, R., Mobasseri, M. et al. Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: A randomized clinical trial., Chin. J. Integr. Med. 20, 347–352 (2014). https://doi.org/10.1007/s11655-014-1804-8

Samira Pourmoradian, Reza Mahdavi, Majid Mobasseri, et al. Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: A randomized clinical trial[J]. Chinese Journal of Integrative Medicine, 2014,20(5):347-352.
Pourmoradian, S., Mahdavi, R., Mobasseri, M. et al. Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: A randomized clinical trial., Chin. J. Integr. Med. 20, 347–352 (2014). https://doi.org/10.1007/s11655-014-1804-8 DOI：

Samira Pourmoradian, Reza Mahdavi, Majid Mobasseri, et al. Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: A randomized clinical trial[J]. Chinese Journal of Integrative Medicine, 2014,20(5):347-352. DOI： 10.1007/s11655-014-1804-8.

摘要

It has been proposed that royal jelly has antioxidant properties and may improve oxidative stress and glycemic control. Therefore

we investigated the effects of royal jelly supplementation in diabetic females. In this pilot

parallel design randomized clinical trial

50 female volunteers with type 2 diabetes were randomly allocated to the supplemented (25

cases) and placebo (25

cases) groups

based on random block procedure produced by Random Allocation Software

given a daily dose of 1

000 mg royal jelly soft gel or placebo

respectively

for 8 weeks. Before and after intervention

glycemic control indices

antioxidant and oxidative stress factors were measured. After royal jelly supplementation

the mean fasting blood glucose decreased remarkably (163.05±42.51 mg/dL vs. 149.68±42.7 mg/dL). Royal jelly supplementation resulted in significant reduction in the mean serum glycosylated hemoglobin levels (8.67%±2.24% vs. 7.05%±1.45%

P=0.001) and significant elevation in the mean insulin concentration (70.28±29.16 pmol/L vs. 86.46±27.50 pmol/L

P=0.01). Supplementation significantly increased erythrocyte superoxidase dismutase and glutathione peroxidase activities and decreased malondialdehyde levels (P<0.05). At the end of study

the mean total antioxidant capacity elevated insignificantly in both groups. On the basis of our findings

it seems that royal jelly supplementation may be beneficial in controlling diabetes outcomes. Further studies with larger sample size are warranted.

Abstract

It has been proposed that royal jelly has antioxidant properties and may improve oxidative stress and glycemic control. Therefore

we investigated the effects of royal jelly supplementation in diabetic females. In this pilot

parallel design randomized clinical trial

50 female volunteers with type 2 diabetes were randomly allocated to the supplemented (25

cases) and placebo (25

cases) groups

based on random block procedure produced by Random Allocation Software

given a daily dose of 1

000 mg royal jelly soft gel or placebo

respectively

for 8 weeks. Before and after intervention

glycemic control indices

antioxidant and oxidative stress factors were measured. After royal jelly supplementation

P=0.001) and significant elevation in the mean insulin concentration (70.28±29.16 pmol/L vs. 86.46±27.50 pmol/L

P=0.01). Supplementation significantly increased erythrocyte superoxidase dismutase and glutathione peroxidase activities and decreased malondialdehyde levels (P<0.05). At the end of study

the mean total antioxidant capacity elevated insignificantly in both groups. On the basis of our findings

it seems that royal jelly supplementation may be beneficial in controlling diabetes outcomes. Further studies with larger sample size are warranted.

关键词

glycemic controloxidative stressRoyal jellytype 2 diabetes

Keywords

glycemic controloxidative stressRoyal jellytype 2 diabetes

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