A randomized clinical study on optimum proposal of integration of disease and syndrome to treat viral myocarditis

Shi-chao Lu; Jun-ping Zhang; Ya-ping Zhu; Ya-nan Zhou; Nan Xiao; Xiao-chen Guo; Xiao-ling Wang; Jie Rong; Mei-fang Wu

doi:10.1007/s11655-014-1815-5

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A randomized clinical study on optimum proposal of integration of disease and syndrome to treat viral myocarditis

OriginalPaper | Updated：2021-08-27

- A randomized clinical study on optimum proposal of integration of disease and syndrome to treat viral myocarditis
- A randomized clinical study on optimum proposal of integration of disease and syndrome to treat viral myocarditis
- 中国结合医学杂志（英文版） 2015年21卷第3期页码：176-182
- Affiliations：
  
  1. Tianjin University of Traditional Chinese Medicine,Tianjin,China
  2. First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin,China
- Author bio：
- Funds：
  
  Supported by the 11th Five-year Plan National Science and Technology Support Program (No. 2007BAI20B073)
- DOI：10.1007/s11655-014-1815-5
  中图分类号：
- 纸质出版日期：2015，
  
  网络出版日期：2014-5-23，
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Lu, Sc., Zhang, Jp., Zhu, Yp. et al. A randomized clinical study on optimum proposal of integration of disease and syndrome to treat viral myocarditis., Chin. J. Integr. Med. 21, 176–182 (2015). https://doi.org/10.1007/s11655-014-1815-5

Shi-chao Lu, Jun-ping Zhang, Ya-ping Zhu, et al. A randomized clinical study on optimum proposal of integration of disease and syndrome to treat viral myocarditis[J]. Chinese Journal of Integrative Medicine, 2015,21(3):176-182.
Lu, Sc., Zhang, Jp., Zhu, Yp. et al. A randomized clinical study on optimum proposal of integration of disease and syndrome to treat viral myocarditis., Chin. J. Integr. Med. 21, 176–182 (2015). https://doi.org/10.1007/s11655-014-1815-5 DOI：

Shi-chao Lu, Jun-ping Zhang, Ya-ping Zhu, et al. A randomized clinical study on optimum proposal of integration of disease and syndrome to treat viral myocarditis[J]. Chinese Journal of Integrative Medicine, 2015,21(3):176-182. DOI： 10.1007/s11655-014-1815-5.

摘要

To determine the optimum treatment for viral myocarditis (VMC). A total of 126 VMC patients were randomly divided into the control group (42 cases) that was treated with conventional Western medicine

and the intervention group (84 cases) that was treated with a combination of Chinese medicine (CM) and Western medicine intervention termed optimum proposal of integration of disease and syndrome (OPIDS). Before and after 4 weeks of treatment

the integral of CM syndrome

self-rating depression and anxiety scales (SDS and SAS

respectively)

echocardiograms (ECGs)

heart rate variability and left ventricular systolic function were observed. Compared with the control group

the intervention group showed significant reductions on the SDS and SAS (P <0.05); improvement of premature ventricular beats

atrioventricular blocks

ST-segment abnormalities

and significant T wave changes (P <0.05); greater reductions in standard deviation of NN intervals (SDNN)

standard deviation for per 5 min averages NN intervals (SDANN)

and root-mean-square of successive difference of NN intervals (rMSSD) (P <0.05); and increases in cardiac output

stroke volume

and ejection fraction

the last of which was statistically significant (P <0.05). Overall

the treatment efficacy rate was significantly better P<0.05) in the intervention group (75.61%) compared with the control group (69.70%). OPIDS is quite effective in treating VMC and improves symptoms such as anxiety and depression

left ventricular systolic dysfunction

premature ventricular contraction

and cardiac autonomic nervous system dysfunction. [Registration: Chinese clinical trial center (No. ChiCTR-TRC-00000298)]

Abstract

To determine the optimum treatment for viral myocarditis (VMC). A total of 126 VMC patients were randomly divided into the control group (42 cases) that was treated with conventional Western medicine

the integral of CM syndrome

self-rating depression and anxiety scales (SDS and SAS

respectively)

echocardiograms (ECGs)

heart rate variability and left ventricular systolic function were observed. Compared with the control group

the intervention group showed significant reductions on the SDS and SAS (P <0.05); improvement of premature ventricular beats

atrioventricular blocks

ST-segment abnormalities

and significant T wave changes (P <0.05); greater reductions in standard deviation of NN intervals (SDNN)

standard deviation for per 5 min averages NN intervals (SDANN)

and root-mean-square of successive difference of NN intervals (rMSSD) (P <0.05); and increases in cardiac output

stroke volume

and ejection fraction

the last of which was statistically significant (P <0.05). Overall

left ventricular systolic dysfunction

premature ventricular contraction

and cardiac autonomic nervous system dysfunction. [Registration: Chinese clinical trial center (No. ChiCTR-TRC-00000298)]

关键词

Viral MyocarditisChinese Medicinerandomized clinical trial

Keywords

Viral MyocarditisChinese Medicinerandomized clinical trial

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