Effects of Ginkgo biloba extract on periodontal pathogens and its clinical efficacy as adjuvant treatment

Qian Cheng; Wei-min Gao; Bin Cao; Ying-mei Liu; Mei Lin; Liang-qiong Zhang; Yi-song Wang; Zuo-min Wang

doi:10.1007/s11655-014-1824-4

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Effects of Ginkgo biloba extract on periodontal pathogens and its clinical efficacy as adjuvant treatment

OriginalPaper | Updated：2021-08-27

- Effects of Ginkgo biloba extract on periodontal pathogens and its clinical efficacy as adjuvant treatment
- Effects of Ginkgo biloba extract on periodontal pathogens and its clinical efficacy as adjuvant treatment
- 中国结合医学杂志（英文版） 2014年20卷第10期页码：729-736
- Affiliations：
  
  1. Department of Stomatology, Beijing Chaoyang Hospital, Capital Medical University,Beijing,China
  2. Department of Infectious Diseases and Clinical Microbiology, Beijing Chaoyang Hospital, Beijing Institute of Respiratory Medicine, Capital Medical University,Beijing,China
  3. Department of Microbiology, Capital Medical University,Beijing,China
- Author bio：
- Funds：
  
  Supported by Capital Medical University Basic-clinical Cooperation Research Fund (No. 12JL-L10)
- DOI：10.1007/s11655-014-1824-4
  中图分类号：
- 纸质出版日期：2014，
  
  网络出版日期：2014-8-6，
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Cheng, Q., Gao, Wm., Cao, B. et al. Effects of Ginkgo biloba extract on periodontal pathogens and its clinical efficacy as adjuvant treatment., Chin. J. Integr. Med. 20, 729–736 (2014). https://doi.org/10.1007/s11655-014-1824-4

Qian Cheng, Wei-min Gao, Bin Cao, et al. Effects of Ginkgo biloba extract on periodontal pathogens and its clinical efficacy as adjuvant treatment[J]. Chinese Journal of Integrative Medicine, 2014,20(10):729-736.
Cheng, Q., Gao, Wm., Cao, B. et al. Effects of Ginkgo biloba extract on periodontal pathogens and its clinical efficacy as adjuvant treatment., Chin. J. Integr. Med. 20, 729–736 (2014). https://doi.org/10.1007/s11655-014-1824-4 DOI：

Qian Cheng, Wei-min Gao, Bin Cao, et al. Effects of Ginkgo biloba extract on periodontal pathogens and its clinical efficacy as adjuvant treatment[J]. Chinese Journal of Integrative Medicine, 2014,20(10):729-736. DOI： 10.1007/s11655-014-1824-4.

摘要

To determine the effects of Ginkgo biloba extract (EGB) on major periodontal pathogens in subgingival plaque. Sixty patients with moderate to severe periodontitis were selected and randomly assigned to 3 groups: EGB group

a positive (periocline) and a negative control groups. Subgingival plaque samples were collected before treatment and 1 week

2 months and 4 months after treatment. The detection rates of 4 major periodontal pathogens—Treponema denticola (Td)

Tannerella forsythus (Tf)

Prevotella intermedia (Pi)

and Porphyromonas gingivalis (Pg)—were detected by polymerase chain reaction (PCR). Clinical indicators were examined before treatment

3 and 6 months after treatment. EGB significantly decreased the detection rate of all the 4 pathogens 1 week after treatment

and then gradually increased at 2 and 4 months. EGB’s inhibition effect was better than or comparable to periocline

except for Pg in short-term. The difference of plaque index (PLI) and bleeding index (BI) was not statistically significant among the groups

while for probing depth (PD) and attachment loss (AL)

the difference was statistically significant between the EGB group and negative control group at 3 and 6 months after treatment. EGB significantly inhibited major periodontal pathogens and can be used as an adjuvant for periodontitis treatment.

Abstract

a positive (periocline) and a negative control groups. Subgingival plaque samples were collected before treatment and 1 week

2 months and 4 months after treatment. The detection rates of 4 major periodontal pathogens—Treponema denticola (Td)

Tannerella forsythus (Tf)

Prevotella intermedia (Pi)

and Porphyromonas gingivalis (Pg)—were detected by polymerase chain reaction (PCR). Clinical indicators were examined before treatment

3 and 6 months after treatment. EGB significantly decreased the detection rate of all the 4 pathogens 1 week after treatment

and then gradually increased at 2 and 4 months. EGB’s inhibition effect was better than or comparable to periocline

except for Pg in short-term. The difference of plaque index (PLI) and bleeding index (BI) was not statistically significant among the groups

while for probing depth (PD) and attachment loss (AL)

关键词

Ginkgo Biloba Extractperiodontal pathogensperiodontitisChinese Medicine

Keywords

Ginkgo Biloba Extractperiodontal pathogensperiodontitisChinese Medicine

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