Astragalus membranaceus Injection combined with conventional treatment for viral myocarditis: A systematic review of randomized controlled trials

Yuan-lin Piao; Xiao-chun Liang

doi:10.1007/s11655-014-1825-3

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Astragalus membranaceus Injection combined with conventional treatment for viral myocarditis: A systematic review of randomized controlled trials

OriginalPaper | Updated：2021-08-27

- Astragalus membranaceus Injection combined with conventional treatment for viral myocarditis: A systematic review of randomized controlled trials
- Astragalus membranaceus Injection combined with conventional treatment for viral myocarditis: A systematic review of randomized controlled trials
- 中国结合医学杂志（英文版） 2014年20卷第10期页码：787-791
- Affiliations：
  
  Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences,Beijing,China
- Author bio：
- Funds：
  
  Supported by the Health Industry Scientific Research Special Funding Subproject (No. 200902008-04)
- DOI：10.1007/s11655-014-1825-3
  中图分类号：
- 纸质出版日期：2014，
  
  网络出版日期：2014-8-6，
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Piao, Yl., Liang, Xc. , Astragalus membranaceus Injection combined with conventional treatment for viral myocarditis: A systematic review of randomized controlled trials., Chin. J. Integr. Med. 20, 787–791 (2014). https://doi.org/10.1007/s11655-014-1825-3

Yuan-lin Piao, Xiao-chun Liang. Astragalus membranaceus Injection combined with conventional treatment for viral myocarditis: A systematic review of randomized controlled trials[J]. Chinese Journal of Integrative Medicine, 2014,20(10):787-791.
Piao, Yl., Liang, Xc. , Astragalus membranaceus Injection combined with conventional treatment for viral myocarditis: A systematic review of randomized controlled trials., Chin. J. Integr. Med. 20, 787–791 (2014). https://doi.org/10.1007/s11655-014-1825-3 DOI：

Yuan-lin Piao, Xiao-chun Liang. Astragalus membranaceus Injection combined with conventional treatment for viral myocarditis: A systematic review of randomized controlled trials[J]. Chinese Journal of Integrative Medicine, 2014,20(10):787-791. DOI： 10.1007/s11655-014-1825-3.

摘要

To assess the efficacy and safety of Astragalus membranaceus Injection combined with conventional therapy in the treatment of viral myocarditis. Randomized controlled trials (RCTs) of A. membranaceus Injection combined with conventional treatment compared with conventional treatment alone were included. Study population characteristics and outcome results were extracted independently by two assessors. Meta-analysis was performed for data available. Six RCTs

involving 639 participants

were included in this study. The methodological quality of the included trials was generally low

and there was high risk of publication bias in the included trials. The total effective rate of A. membranaceus Injection combined with conventional treatment was significantly higher than that of conventional treatment alone. Compared with conventional treatment

the cointervention treatment group showed significant recovery in myocardium enzyme levels and electrocardiography. Two RCTs reported there were no adverse effects from A. membranaceus Injection combined with conventional treatment. A. membranaceus Injection combined with conventional treatment appeared to be more efficacious compared with conventional treatment alone for treating viral myocarditis. However

this conclusion should be cautiously interpreted due to low methodological quality

small sample size

limited number of trials

and high risk of publication bias and other unidentified risks of bias. The safety of A. membranaceus Injection combined with conventional treatment remains uncertain.

Abstract

involving 639 participants

were included in this study. The methodological quality of the included trials was generally low

this conclusion should be cautiously interpreted due to low methodological quality

small sample size

limited number of trials

and high risk of publication bias and other unidentified risks of bias. The safety of A. membranaceus Injection combined with conventional treatment remains uncertain.

关键词

Viral MyocarditisAstragalus membranaceus Injectionsystematic reviewrandomized controlled trialChinese Medicine

Keywords

Viral MyocarditisAstragalus membranaceus Injectionsystematic reviewrandomized controlled trialChinese Medicine

references

Sagar S, Liu PP, Cooper Jr LT. Myocarditis. Lancet 2012;379:738–747.

Cooper Jr LT. Myocarditis. N Engl J Med 2009;360:1526–1538.

Schulthz JC, Hilliard AA, Cooper Jr LT, Rihal CS. Diagnosis and treatment of viral myocarditis. Mayo Clin Proc 2009;84:1001–1009.

Liu ZL, Liu ZJ, Liu JP, Kwong JS. Herbal medicines for viral myocarditis. Cochrane Database Syst Rev 2012;11:CD003711.

Chen XJ, Bian ZP, Lu S, Xu JD, Gu CR, Yang D, et al. Cardiac protective effect of Astragalus on viral myocarditis mice: comparison with Perindopril. Am J Chin Med 2006;34:493–502.

Guan FY, Liu Y, Li H, Yang SJ. Protective effects of Astragalus membranaceus Injection on viral myocarditis in mice. J Jilin Univ Med Edition (Chin) 2005;31:717–719.

Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary. Control Clin Trials 1996;17:1–12.

Zou FW. Astragalus Injection treatment on 48 patients with viral myocarditis. China Pharmaceuticals (Chin) 2001;10:38.

Guo YC. Effects of Astragalus membranaceus Injection on children’s viral myocarditis. Lishizhen Med Mater Med Res (Chin) 2003;14:408.

Zhang YF, Yang GD, Mao LX. Clinical observation on therapeutic effects of integrated traditional Chinese and Western medicine in treatment of acute viral myocarditis. Chin J Integr Tradit West Med Inten Crit Care (Chin) 2005;12:363–365.

Wu YX. Astragalus membranaceus Injection treatment on 119 children with viral myocarditis. China Pract Med (Chin) 2009;4:161.

Wang LJ. Effects of Astragalus membranaceus Injection on viral myocarditis in children. China Modern Med (Chin) 2011;18:55–56.

Wang YQ, Jiang AL. Clinical observation of Astragalus membranaceus Injection on viral myocarditis in children. Guide China Med (Chin) 2012;10:267–278.

Dechartres A, Trinquart L, Boutron I, Ravaud P. Influence of trial sample size on treatment effect estimates: metaepidemiological study. BMJ 2013;346:f2304.

Gu YH, Du JX. Adverse drug reactions induced by Astragalus membranaceus Injection: analysis of 95 cases. China Pharm (Chin) 2012;23:334–336.

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