Clinical observations of sequential therapy with Chinese medicine and hysteroscopic mechanical stimulation of the endometrium in infertile patients with repeated implantation failure undergoing frozen-thawed embryo transfer

Xiao-le Zhang; Yong-lun Fu; Yan Kang; Cong Qi; Qin-hua Zhang; Yan-ping Kuang

doi:10.1007/s11655-014-1843-1

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Clinical observations of sequential therapy with Chinese medicine and hysteroscopic mechanical stimulation of the endometrium in infertile patients with repeated implantation failure undergoing frozen-thawed embryo transfer

OriginalPaper | Updated：2021-08-27

- Clinical observations of sequential therapy with Chinese medicine and hysteroscopic mechanical stimulation of the endometrium in infertile patients with repeated implantation failure undergoing frozen-thawed embryo transfer
- Clinical observations of sequential therapy with Chinese medicine and hysteroscopic mechanical stimulation of the endometrium in infertile patients with repeated implantation failure undergoing frozen-thawed embryo transfer
- 中国结合医学杂志（英文版） 2015年21卷第4期页码：249-253
- Affiliations：
  
  1. Department of Gynecology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine,Shanghai,China
  2. Department of Assisted Reproduction, the 9th Hospital, Shanghai Jiaotong University School of Medicine,Shanghai,China
- Author bio：
- Funds：
  
  Supported by Shanghai Municipal Health Bureau Foundation of Chinese Traditional Medicine (No. 2010L026A)
- DOI：10.1007/s11655-014-1843-1
  中图分类号：
- 纸质出版日期：2015，
  
  网络出版日期：2014-12-9，
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Zhang, Xl., Fu, Yl., Kang, Y. et al. Clinical observations of sequential therapy with Chinese medicine and hysteroscopic mechanical stimulation of the endometrium in infertile patients with repeated implantation failure undergoing frozen-thawed embryo transfer., Chin. J. Integr. Med. 21, 249–253 (2015). https://doi.org/10.1007/s11655-014-1843-1

Xiao-le Zhang, Yong-lun Fu, Yan Kang, et al. Clinical observations of sequential therapy with Chinese medicine and hysteroscopic mechanical stimulation of the endometrium in infertile patients with repeated implantation failure undergoing frozen-thawed embryo transfer[J]. Chinese Journal of Integrative Medicine, 2015,21(4):249-253.
Zhang, Xl., Fu, Yl., Kang, Y. et al. Clinical observations of sequential therapy with Chinese medicine and hysteroscopic mechanical stimulation of the endometrium in infertile patients with repeated implantation failure undergoing frozen-thawed embryo transfer., Chin. J. Integr. Med. 21, 249–253 (2015). https://doi.org/10.1007/s11655-014-1843-1 DOI：

Xiao-le Zhang, Yong-lun Fu, Yan Kang, et al. Clinical observations of sequential therapy with Chinese medicine and hysteroscopic mechanical stimulation of the endometrium in infertile patients with repeated implantation failure undergoing frozen-thawed embryo transfer[J]. Chinese Journal of Integrative Medicine, 2015,21(4):249-253. DOI： 10.1007/s11655-014-1843-1.

摘要

To investigate the clinical effect of sequential therapeutic intervention Yupei Qisun [compensating for weakness by invigorating Kidney (Shen) and Spleen (Pi) in advance] in Chinese medicine (CM) and hysteroscopic endometrial mechanical stimulation on the treatment of infertile patients with repeated implantation failure (RIF); and to study the differences in patients’ endometrial thickness and type on the day of embryo transfer

serum hormone levels on embryo transfer day and clinical pregnancy outcomes. In the clinical study

168 frozen-thawed embryo transfer (FET) cycles for couples with RIF conforming to the research protocol were randomly divided into three groups: a CM group with 56 cycles (CM combined with FET)

a hysteroscopy group with 55 cycles (hysteroscopic endometrial mechanical stimulation)

and a control group with 57 cycles (conventional FET). Differences in endometrial thickness on the embryo transfer day

levels of serum estradiol (E2) and progesterone (P) on the embryo transfer day

the E2/P ratio on the embryo transfer day

biochemical and clinical pregnancy rates

implantation rate

abnormal pregnancy rate and other indices were compared among the three groups. Endometrial thickness

E2 and P levels

and the E2/P ratio on embryo transfer day and other factors had no significant differences among groups. The biochemical pregnancy

clinical pregnancy

and implantation rates of the CM and hysteroscopy groups were significantly higher than the control group (P<0.05)

and there were no significant differences between these two groups. The abnormal pregnancy rate had no significant difference among the three groups.

Abstract

serum hormone levels on embryo transfer day and clinical pregnancy outcomes. In the clinical study

168 frozen-thawed embryo transfer (FET) cycles for couples with RIF conforming to the research protocol were randomly divided into three groups: a CM group with 56 cycles (CM combined with FET)

a hysteroscopy group with 55 cycles (hysteroscopic endometrial mechanical stimulation)

and a control group with 57 cycles (conventional FET). Differences in endometrial thickness on the embryo transfer day

levels of serum estradiol (E2) and progesterone (P) on the embryo transfer day

the E2/P ratio on the embryo transfer day

biochemical and clinical pregnancy rates

implantation rate

abnormal pregnancy rate and other indices were compared among the three groups. Endometrial thickness

E2 and P levels

and the E2/P ratio on embryo transfer day and other factors had no significant differences among groups. The biochemical pregnancy

clinical pregnancy

and implantation rates of the CM and hysteroscopy groups were significantly higher than the control group (P<0.05)

and there were no significant differences between these two groups. The abnormal pregnancy rate had no significant difference among the three groups.

关键词

sequential therapyChinese MedicineYupei Qisunrepeated implantation failurefrozen embryo transferhysteroscopy

Keywords

sequential therapyChinese MedicineYupei Qisunrepeated implantation failurefrozen embryo transferhysteroscopy

references

Margalioth EJ, Ben-Chetrit A, Gal M, Eldar-Geva T. Investigation and treatment of repeated implantation failure following IVF-ET. Hum Reprod 2006;21:3036–3043.

Cummins JM, Breen TM, Harrison KL, Shaw JM, Wilson LM, Hennessey JF. A formula for scoring human embryo growth rates in in vitro fertilization: its value in predicting pregnancy and in comparison with visual estimates of embryo quality. J in vitro Fertil Embryo Transf 1986;3:284–295.

Gardner DK, Lane M, Stevens J, Schoolcraft WB. Blastocyst score affects implantantation and prengnancy outcome: towards a single blastocyst transfer. Fertil Steril 2000;73:1155–1158.

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Tianya H, Fu YL, Kuang YP. Impact of non-GnRH-a downregulated hormone replacement therapy and HMG stimulation as endometrial preparation protocols on frozen-thawed embryo transfer. Reprod Contracep (Chin) 2006;26:344–347.

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Wang Y, Huang XY, Niu ZH, Zhang AJ, Feng Y. Influence of local injury treatment on theimplantation related factors and IVF pregnancy outcome. Reprod Contracep (Chin) 2007;27:455–461.

Zhu WJ, Li XM, Chen XM, Zhang L. Effect of Zishen Yutai Pill on embryo implantation rate in patients undergoing fertilization embryo transfer in vitro. Chin J Integr Tradit West Med (Chin) 2002;22:729–737.

Yu S, Kuang YP, Qi C. Effects of Yupei Qisun Sequential method of Chinese medicine on correlated indices of repeated implantation failure patients in the fresh cycle. Chin J Integr Tradit West Med (Chin) 2012;32:763–765.

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