Effect of Longbishu Capsule (癃闭舒胶囊) plus doxazosin on benign prostatic hyperplasia: A randomized controlled trial

Chun-sheng Song; Jun Guo; De-gui Chang; Lei Chen; Rui Zhang; Jia-you Zhao; Fu Wang; Qiang Zhang

doi:10.1007/s11655-014-1844-0

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Effect of Longbishu Capsule (癃闭舒胶囊) plus doxazosin on benign prostatic hyperplasia: A randomized controlled trial

OriginalPaper | Updated：2021-08-27

- Effect of Longbishu Capsule (癃闭舒胶囊) plus doxazosin on benign prostatic hyperplasia: A randomized controlled trial
- Effect of Longbishu Capsule (癃闭舒胶囊) plus doxazosin on benign prostatic hyperplasia: A randomized controlled trial
- 中国结合医学杂志（英文版） 2014年20卷第11期页码：818-822
- Affiliations：
  
  1. Graduate School of China Academy of Chinese Medical Sciences,Beijing,China
  2. Department of Andrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing,China
  3. Department of Urology and Andrology, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu,China
  4. Department of Urology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,China
  5. Department of Andrology, the Second Affiliated Hospital to Heilongjiang University of Traditional Chinese Medicine,Harbin,China
- Author bio：
- Funds：
  
  Supported by the Project of Science Research for the 11th Five Year Plan (No. 2007BAI20B044)
- DOI：10.1007/s11655-014-1844-0
  中图分类号：
- 纸质出版日期：2014，
  
  网络出版日期：2014-6-18，
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Song, Cs., Guo, J., Chang, Dg. et al. Effect of Longbishu Capsule (癃闭舒胶囊) plus doxazosin on benign prostatic hyperplasia: A randomized controlled trial., Chin. J. Integr. Med. 20, 818–822 (2014). https://doi.org/10.1007/s11655-014-1844-0

Chun-sheng Song, Jun Guo, De-gui Chang, et al. Effect of Longbishu Capsule (癃闭舒胶囊) plus doxazosin on benign prostatic hyperplasia: A randomized controlled trial[J]. Chinese Journal of Integrative Medicine, 2014,20(11):818-822.
Song, Cs., Guo, J., Chang, Dg. et al. Effect of Longbishu Capsule (癃闭舒胶囊) plus doxazosin on benign prostatic hyperplasia: A randomized controlled trial., Chin. J. Integr. Med. 20, 818–822 (2014). https://doi.org/10.1007/s11655-014-1844-0 DOI：

Chun-sheng Song, Jun Guo, De-gui Chang, et al. Effect of Longbishu Capsule (癃闭舒胶囊) plus doxazosin on benign prostatic hyperplasia: A randomized controlled trial[J]. Chinese Journal of Integrative Medicine, 2014,20(11):818-822. DOI： 10.1007/s11655-014-1844-0.

摘要

To investigate the effect of Longbishu Capsule (癃闭舒胶囊

LBS)

doxazosin

and combination therapy on benign prostatic hyperplasia (BPH). A randomized

double-blind

multi-center parallel trial was conducted involving 360 patients in hospitals in Beijing (108 cases)

Heilongjiang (90 cases)

Sichuan (90 cases)

Shanghai (72 cases)

China. They were randomly assigned with central randomization method to group A (LBS placebo plus doxazosin)

group B (LBS plus doxazosin) or group C (LBS plus doxazosin placebo)

120 cases for each group. The international prostate symptom score

maximum urinary flow rate

postvoid residual urine volume and prostate volume were measured for evaluating the efficacy of the three treatments. At baseline

there was no significant difference in the measured variables among the three groups. After 12-month treatment

the three groups showed significant improvements in IPSS and maximum urinary flow rate from baseline (P<0.01). Although postvoid residual urine volume was not significantly different from the baseline in group A (P>0.05)

it significantly decreased in group B and C (P<0.05). The incidence of adverse events were similar among the three groups. The treatment of LBS alone or LBS plus doxazosin was able to significantly improve IPSS in patients with BPH. The treatments may reduce the increase in prostate volume and postvoid residual urine volume as well.

Abstract

To investigate the effect of Longbishu Capsule (癃闭舒胶囊

LBS)

doxazosin

and combination therapy on benign prostatic hyperplasia (BPH). A randomized

double-blind

multi-center parallel trial was conducted involving 360 patients in hospitals in Beijing (108 cases)

Heilongjiang (90 cases)

Sichuan (90 cases)

Shanghai (72 cases)

China. They were randomly assigned with central randomization method to group A (LBS placebo plus doxazosin)

group B (LBS plus doxazosin) or group C (LBS plus doxazosin placebo)

120 cases for each group. The international prostate symptom score

maximum urinary flow rate

postvoid residual urine volume and prostate volume were measured for evaluating the efficacy of the three treatments. At baseline

there was no significant difference in the measured variables among the three groups. After 12-month treatment

关键词

benign prostatic hyperplasiacombination therapyLongbishu Capsuledoxazosinclinical progressionChinese Medicine

Keywords

benign prostatic hyperplasiacombination therapyLongbishu Capsuledoxazosinclinical progressionChinese Medicine

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