Standardized treatment of chinese medicine decoction for cancer pain patients with opioid-induced constipation: A multi-center prospective randomized controlled study

Chang-ming Chen; Li-zhu Lin; En-xin Zhang

doi:10.1007/s11655-014-1864-9

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Standardized treatment of chinese medicine decoction for cancer pain patients with opioid-induced constipation: A multi-center prospective randomized controlled study

OriginalPaper | Updated：2021-08-27

- Standardized treatment of chinese medicine decoction for cancer pain patients with opioid-induced constipation: A multi-center prospective randomized controlled study
- Standardized treatment of chinese medicine decoction for cancer pain patients with opioid-induced constipation: A multi-center prospective randomized controlled study
- 中国结合医学杂志（英文版） 2014年20卷第7期页码：496-502
- Affiliations：
  
  Department of Oncology, First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-014-1864-9
  中图分类号：
- 纸质出版日期：2014，
  
  网络出版日期：2014-6-28，
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Chen, Cm., Lin, Lz. & Zhang, Ex. Standardized treatment of chinese medicine decoction for cancer pain patients with opioid-induced constipation: A multi-center prospective randomized controlled study., Chin. J. Integr. Med. 20, 496–502 (2014). https://doi.org/10.1007/s11655-014-1864-9

Chang-ming Chen, Li-zhu Lin, En-xin Zhang. Standardized treatment of chinese medicine decoction for cancer pain patients with opioid-induced constipation: A multi-center prospective randomized controlled study[J]. Chinese Journal of Integrative Medicine, 2014,20(7):496-502.
Chen, Cm., Lin, Lz. & Zhang, Ex. Standardized treatment of chinese medicine decoction for cancer pain patients with opioid-induced constipation: A multi-center prospective randomized controlled study., Chin. J. Integr. Med. 20, 496–502 (2014). https://doi.org/10.1007/s11655-014-1864-9 DOI：

Chang-ming Chen, Li-zhu Lin, En-xin Zhang. Standardized treatment of chinese medicine decoction for cancer pain patients with opioid-induced constipation: A multi-center prospective randomized controlled study[J]. Chinese Journal of Integrative Medicine, 2014,20(7):496-502. DOI： 10.1007/s11655-014-1864-9.

摘要

To observe the efficacy and the influence on quality of life (QOL) of syndrome differentiation treatment with Chinese medicine (CM) for opioid-induced constipation as well as the safety and influence on analgesic effect of opioids. Totally 406 cases enrolled from 53 collaborating medical centers were randomly assigned to a CM group and a control group. The CM group were treated with CM decoction based on syndrome differentiation

and the control group were treated with Phenolphthalein Tablet. Both groups were treated for 14 days. Cleveland constipation score (CCS)

numerical rating scale (NRS) of pain and Chinese version of European Organisation for Research and Treatment of Cancer

Quality of Life Questionnaire-C30 V3.0 (EORTC QLQ-C30 V3.0) were used to evaluate the efficacy

pain controlled and QOL status. The comparisons of CCS score reduction and QOL between the two groups after treatment suggested that the improvements of constipation and QOL in the CM group were better than that in the control group (P<0.05). The total efficiency of the CM group was better than the control group (93.5% vs. 86.4%

P<0.05). There was no significant difference in NRS scores between before and after treatment in both groups. There was no serious drug-related adverse event during the course of study. CM decoction could effectively treat opioid-induced constipation and improve patients’ QOL at the same time. It is safe and doesn’t affect the analgesic effect of opioids when treating constipation.

Abstract

and the control group were treated with Phenolphthalein Tablet. Both groups were treated for 14 days. Cleveland constipation score (CCS)

numerical rating scale (NRS) of pain and Chinese version of European Organisation for Research and Treatment of Cancer

Quality of Life Questionnaire-C30 V3.0 (EORTC QLQ-C30 V3.0) were used to evaluate the efficacy

关键词

Chinese MedicineopioidConstipationquality of life

Keywords

Chinese MedicineopioidConstipationquality of life

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