Blood stasis syndrome in Japan and its molecular biological analysis

Hirozo Goto

doi:10.1007/s11655-014-1882-7

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Blood stasis syndrome in Japan and its molecular biological analysis

OriginalPaper | Updated：2021-08-27

- Blood stasis syndrome in Japan and its molecular biological analysis
- Blood stasis syndrome in Japan and its molecular biological analysis
- 中国结合医学杂志（英文版） 2014年20卷第7期页码：490-495
- Affiliations：
  
  Department of Kampo Medicine, Hokusei Hospital,Toyama,Japan
- Author bio：
- Funds：
- DOI：10.1007/s11655-014-1882-7
  中图分类号：
- 纸质出版日期：2014，
  
  网络出版日期：2014-6-28，
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Goto, H. Blood stasis syndrome in Japan and its molecular biological analysis., Chin. J. Integr. Med. 20, 490–495 (2014). https://doi.org/10.1007/s11655-014-1882-7

Hirozo Goto. Blood stasis syndrome in Japan and its molecular biological analysis[J]. Chinese Journal of Integrative Medicine, 2014,20(7):490-495.
Goto, H. Blood stasis syndrome in Japan and its molecular biological analysis., Chin. J. Integr. Med. 20, 490–495 (2014). https://doi.org/10.1007/s11655-014-1882-7 DOI：

Hirozo Goto. Blood stasis syndrome in Japan and its molecular biological analysis[J]. Chinese Journal of Integrative Medicine, 2014,20(7):490-495. DOI： 10.1007/s11655-014-1882-7.

摘要

Blood stasis syndrome is one of the pathological concepts of Oriental traditional medicine. In Oriental traditional medicine

blood is thought of as not only blood but also as a living component of the body. In fact

blood stasis syndrome is related to not just circulation disorders but dermatological and gynecological and other diseases. In Japan

the concept of blood stasis syndrome is based on the past literature

for instance

Synopsis of Golden Chamber (Jin Kui Yao Lue)

etc. There are many signs of this syndrome

such as a dry mouth

fullness of the abdomen and rough skin. However

the levels of importance of these signs had been unclear. Therefore

in order to determine the levels of seriousness

a scoring system of blood stasis syndrome was made based on multivariate analysis by Dr. Terasawa (Terasawa’s Blood Stasis Score). Using the scoring system

we have studied blood stasis syndrome mainly related to blood circulation using modern techniques of analysis. From the results

we found that patients with blood stasis syndrome showed hemorheological abnormalities

and an improvement in these abnormalities was shown after administration of removing-blood stasis formulae. Furthermore

we have studied blood stasis syndrome from the point of view of molecular biology. We searched for the specific protein expression in blood stasis syndrome by proteomic analysis

and found no specific protein expression. However

there may be a possibility of developing a diagnostic algorithm for blood stasis by construction of a decision tree. During the past few years

as one of the molecular biological factors affecting blood stasis syndrome

we have been studying hypoxia inducible factor

which is located in the upstream of many genes. Above all

blood stasis syndrome is more than just circulatory deficit but encompasses the pathological concept of constant multilateral change in the living body.

Abstract

Blood stasis syndrome is one of the pathological concepts of Oriental traditional medicine. In Oriental traditional medicine

blood is thought of as not only blood but also as a living component of the body. In fact

blood stasis syndrome is related to not just circulation disorders but dermatological and gynecological and other diseases. In Japan

the concept of blood stasis syndrome is based on the past literature

for instance

Synopsis of Golden Chamber (Jin Kui Yao Lue)

etc. There are many signs of this syndrome

such as a dry mouth

fullness of the abdomen and rough skin. However

the levels of importance of these signs had been unclear. Therefore

in order to determine the levels of seriousness

a scoring system of blood stasis syndrome was made based on multivariate analysis by Dr. Terasawa (Terasawa’s Blood Stasis Score). Using the scoring system

we have studied blood stasis syndrome mainly related to blood circulation using modern techniques of analysis. From the results

we found that patients with blood stasis syndrome showed hemorheological abnormalities

and an improvement in these abnormalities was shown after administration of removing-blood stasis formulae. Furthermore

we have studied blood stasis syndrome from the point of view of molecular biology. We searched for the specific protein expression in blood stasis syndrome by proteomic analysis

and found no specific protein expression. However

there may be a possibility of developing a diagnostic algorithm for blood stasis by construction of a decision tree. During the past few years

as one of the molecular biological factors affecting blood stasis syndrome

we have been studying hypoxia inducible factor

which is located in the upstream of many genes. Above all

blood stasis syndrome is more than just circulatory deficit but encompasses the pathological concept of constant multilateral change in the living body.

关键词

Blood Stasis SyndromeTerasawa’s Blood Stasis Scorehemorheological abnormalitiesproteomic analysisdecision treehypoxia inducible factor

Keywords

Blood Stasis SyndromeTerasawa’s Blood Stasis Scorehemorheological abnormalitiesproteomic analysisdecision treehypoxia inducible factor

references

Yumoto K. Kohkan Igaku (one of the Japanese guidebook of Oriental traditional medicine). Tokyo: RYOGEN Co. Ltd; 1983.

Yakazu D. Considerations on Oketsu (stagnation of disordered blood), one of the cardinal pathogenetic factors in Oriental medicine. Int J Orient Med (Jpn) 1975;25:165–185.

Terasawa K, Shinoda H, Imadaya A, Tosa H, Bandoh M, Satoh N. The presentation of diagnostic criteria for “Oketsu” syndrome. Int J Orient Med (Jpn) 1983;34:1–17.

Hanawa T. Lesson of the Japanese traditional medical care. Tokyo: KANEHARA Co. Ltd; 1995.

Terasawa K, Toriizuka K, Tosa H, Ueno M, Hayashi T, Shimizu M. Rheological studies on “Oketsu” syndrome I. The blood viscosity and diagnostic criteria. J Med Pham Soc WAKAN-YAKU (Jpn) 1986;3:98–104.

Hikiami H, Kohta K, Sekiya N, Shimada Y, Itoh T, Terasawa K. Erythrocyte deformability in “Oketsu” syndrome and its relations to erythrocyte viscoelasticity. J Trad Med 1996;13:156–164.

Terasawa K, Toriizuka K, Bandou M, Imadaya A, Tosa H. Effects of medicinal plants on the metabolism of the platelet arachidonic acid. J Med Pharm Soc WAKAN-YAKU (Jpn) 1985;2:310–316.

Kohta K, Hiyama Y, Hamazaki T, Itoh T, Tosa H. Hemorheological studies of “Oketsu” syndrome-erythrocyte aggregation in “Oketsu” syndrome. J Med Pharm Soc WAKAN-YAKU (Jpn) 1992;9:221–228.

Donner M, Siadat M, Stoltz JF: Erythrocyte aggregation, approach by light scattering determination. Biorheology 1988;25:367–375.

Kohta K, Hikiami H, Shimada Y, Matsuda H, Hamazaki T, Terasawa K. Effects of Keishi bukuryo-gan on erythrocyte aggregability in patients with multiple old lacunar infarction. J Med Pharm Soc WAKAN-YAKU (Jpn) 1993;10:251–259.

Nagata Y, Goto H, Hikiami H, Nogami T, Fujimoto M, Shibahara N, Shimada Y. Effect of keishibukuryogan on endothelial function in patients with at least one component of the diagnostic criteria for metabolic syndrome: a controlled clinical trial with crossover design. Evid Based Complement Altern Med 2012;2012:359282.

Goto H, Shimada Y, Akechi Y, Kohta K, Hattori M, Terasawa K. Endotheliumdependent vasodilator effect of extract prepared from the roots of Paeonia lactiflora on isolated rat aorta. Planta Med 1996;62:436–439.

Yanaga A, Goto H, Nakagawa T, Hikiami H, Shibahara N, Shimada Y. Cinnamaldehyde induces endotheliumdependent and -independent vasorelaxant action on isolated rat aorta. Biol Pharm Bull 2006;29:2415–2418.

Tanikawa K, Goto H, Nakamura N, Tanaka N, Hattori M, Itoh T, et al. Endothelium-dependent vasodailator effect of tannin extract from Cinnamonomi Cortex on isolated rat aorta. J Trad Med 1999;16:45–50.

Matsumoto C, Kojima T, Ogawa K, Kamegai S, Oyama T, Goto H, et al. A proteomic approach for the diagnosis of ‘Oketsu’ (blood stasis), a pathophysiologic concept of Japanese traditional (kampo) medicine. Evid Based Complement Altern Med 2008;5:463–74.

Oka H, Goto H, Koizumi K, Nakamura S, Tsuneyama K, Zhou Y, et al. Effect of Hachimijiogan against renal dysfunction and involvement of hypoxia-inducible factor-1α in the remnant kidney model. Evid Based Complement Altern Med 2011;2011:348686.

Oka H, Goto H, Koizumi K, Nogami T, Watari H, Nakamura S, et al. Cinnamaldehyde and paeonol increase HIF-1α activity in proximal tubular epithelial cells under hypoxia. J Trad Med 2011;28:149–157.

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