Paradox of using intensive lowering of blood glucose in diabetics and strategies to overcome it and decrease cardiovascular risks

Xian-pei Heng; Liu-qing Yang; Min-ling Chen; Liang Li; Su-ping Huang; Ying Lei

doi:10.1007/s11655-015-0780-5

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Paradox of using intensive lowering of blood glucose in diabetics and strategies to overcome it and decrease cardiovascular risks

OriginalPaper | Updated：2021-08-27

- Paradox of using intensive lowering of blood glucose in diabetics and strategies to overcome it and decrease cardiovascular risks
- Paradox of using intensive lowering of blood glucose in diabetics and strategies to overcome it and decrease cardiovascular risks
- 中国结合医学杂志（英文版） 2015年21卷第10期页码：791-800
- Affiliations：
  
  1. Department of Endocrinology, Peoples Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Peoples Hospital of Fujian Province,Fuzhou,China
  2. Academy of Integrative Medicine Fujian China,Fuzhou,China
  3. Fujian University of Traditional Chinese Medicine,Fuzhou,China
- Author bio：
- Funds：
  
  Supported by National Natural Science Foundation of China (No. 81173179, 81473550, 81403329), Focal Point Project of Fujian Province in China (No. 2012Y0037), Research Fund for Traditional Chinese Medicine Focus Lab of Fujian Provincial Department of Health (No. wztn 201304), CHEN Keji Development Fund of Integrative Medicine (No. CKJ2009004), and Special Fund for Key Subject of Fujian University of Traditional Chinese Medicine (No. X2014037)
- DOI：10.1007/s11655-015-0780-5
  中图分类号：
- 纸质出版日期：2015，
  
  网络出版日期：2015-11-3，
Scan for full text
Heng, Xp., Yang, Lq., Chen, Ml. et al. Paradox of using intensive lowering of blood glucose in diabetics and strategies to overcome it and decrease cardiovascular risks., Chin. J. Integr. Med. 21, 791–800 (2015). https://doi.org/10.1007/s11655-015-0780-5

Xian-pei Heng, Liu-qing Yang, Min-ling Chen, et al. Paradox of using intensive lowering of blood glucose in diabetics and strategies to overcome it and decrease cardiovascular risks[J]. Chinese Journal of Integrative Medicine, 2015,21(10):791-800.
Heng, Xp., Yang, Lq., Chen, Ml. et al. Paradox of using intensive lowering of blood glucose in diabetics and strategies to overcome it and decrease cardiovascular risks., Chin. J. Integr. Med. 21, 791–800 (2015). https://doi.org/10.1007/s11655-015-0780-5 DOI：

Xian-pei Heng, Liu-qing Yang, Min-ling Chen, et al. Paradox of using intensive lowering of blood glucose in diabetics and strategies to overcome it and decrease cardiovascular risks[J]. Chinese Journal of Integrative Medicine, 2015,21(10):791-800. DOI： 10.1007/s11655-015-0780-5.

摘要

Hyperglycemia significantly increases the risk of cardiovascular disease (CVD) in diabetics. However

it has been shown by a series of large scale international studies that intensive lowering of blood glucose levels not only has very limited benefits against cardiovascular problems in patients

but may even be harmful to patients at a high risk for CVD and/or poor long-term control of blood glucose levels. Therefore

Western medicine is faced with a paradox. One way to solve this may be administration of Chinese herbal medicines that not only regulate blood glucose

blood fat levels and blood pressure

but also act on multiple targets. These medicines can eliminate cytotoxicity of high glucose through anti-inflfl ammatory and anti-oxidant methods

regulation of cytokines and multiple signaling molecules

and maintenance of cell vitality and the cell cycle

etc. This allows hyperglycemic conditions to exist in a healthy manner

which is called “harmless hyperglycemia” Furthermore

these cardiovascular benefits go beyond lowering blood glucose levels. The mechanisms of action not only avoid cardiovascular injury caused by intensive lowering of blood glucose levels

but also decrease the cardiovascular dangers posed by hyperglycemia.

Abstract

Hyperglycemia significantly increases the risk of cardiovascular disease (CVD) in diabetics. However

it has been shown by a series of large scale international studies that intensive lowering of blood glucose levels not only has very limited benefits against cardiovascular problems in patients

but may even be harmful to patients at a high risk for CVD and/or poor long-term control of blood glucose levels. Therefore

Western medicine is faced with a paradox. One way to solve this may be administration of Chinese herbal medicines that not only regulate blood glucose

blood fat levels and blood pressure

but also act on multiple targets. These medicines can eliminate cytotoxicity of high glucose through anti-inflfl ammatory and anti-oxidant methods

regulation of cytokines and multiple signaling molecules

and maintenance of cell vitality and the cell cycle

etc. This allows hyperglycemic conditions to exist in a healthy manner

which is called “harmless hyperglycemia” Furthermore

these cardiovascular benefits go beyond lowering blood glucose levels. The mechanisms of action not only avoid cardiovascular injury caused by intensive lowering of blood glucose levels

but also decrease the cardiovascular dangers posed by hyperglycemia.

关键词

diabetescardiovascular riskChinese Herbal Medicineglucose toxicityharmless hyperglycemia

Keywords

diabetescardiovascular riskChinese Herbal Medicineglucose toxicityharmless hyperglycemia

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