Chinese Herbal Medicine Xingnaojing Injection (醒脑静注射液) for Hypoxic Ischemic Encephalopathy in Newborns: A Systematic Review and Meta-Analysis

Chun-song Yang; Yun-zhu Lin; Qin Guo; Li-li He

doi:10.1007/s11655-015-1974-z

Your Location：

Home >

Browse articles >

Chinese Herbal Medicine Xingnaojing Injection (醒脑静注射液) for Hypoxic Ischemic Encephalopathy in Newborns: A Systematic Review and Meta-Analysis

OriginalPaper | Updated：2021-08-27

- Chinese Herbal Medicine Xingnaojing Injection (醒脑静注射液) for Hypoxic Ischemic Encephalopathy in Newborns: A Systematic Review and Meta-Analysis
- Chinese Herbal Medicine Xingnaojing Injection (醒脑静注射液) for Hypoxic Ischemic Encephalopathy in Newborns: A Systematic Review and Meta-Analysis
- 中国结合医学杂志（英文版） 2018年24卷第2期页码：147-155
- Affiliations：
  
  1. Department of Pharmacy, Evidence-Based Pharmacy Centre, West China Second Hospital, Sichuan University,Chengdu,China
  2. West China Second Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University,Chengdu,China
  3. Department of Pediatrics, West China Second Hospital, Sichuan University,Chengdu,China
  4. College of Chemistry and Environment Protection, Southwest University for Nationalities,Chengdu,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 81373381)
- DOI：10.1007/s11655-015-1974-z
  中图分类号：
- 纸质出版日期：2018，
  
  网络出版日期：2015-5-12，
Scan for full text
Yang, Cs., Lin, Yz., Guo, Q. et al. Chinese Herbal Medicine Xingnaojing Injection (醒脑静注射液) for Hypoxic Ischemic Encephalopathy in Newborns: A Systematic Review and Meta-Analysis., Chin. J. Integr. Med. 24, 147–155 (2018). https://doi.org/10.1007/s11655-015-1974-z

Chun-song Yang, Yun-zhu Lin, Qin Guo, et al. Chinese Herbal Medicine Xingnaojing Injection (醒脑静注射液) for Hypoxic Ischemic Encephalopathy in Newborns: A Systematic Review and Meta-Analysis[J]. Chinese Journal of Integrative Medicine, 2018,24(2):147-155.
Yang, Cs., Lin, Yz., Guo, Q. et al. Chinese Herbal Medicine Xingnaojing Injection (醒脑静注射液) for Hypoxic Ischemic Encephalopathy in Newborns: A Systematic Review and Meta-Analysis., Chin. J. Integr. Med. 24, 147–155 (2018). https://doi.org/10.1007/s11655-015-1974-z DOI：

Chun-song Yang, Yun-zhu Lin, Qin Guo, et al. Chinese Herbal Medicine Xingnaojing Injection (醒脑静注射液) for Hypoxic Ischemic Encephalopathy in Newborns: A Systematic Review and Meta-Analysis[J]. Chinese Journal of Integrative Medicine, 2018,24(2):147-155. DOI： 10.1007/s11655-015-1974-z.

摘要

To evaluate the efficacy and safety of Chinese herbal medicine Xingnaojing Injection (醒脑静注射液) for newborns with hypoxic ischemic encephalopathy (HIE). Literatures were identified by searching the PubMed

EMBASE

Cochrane Library

Cochrane Central

and four Chinese literature databases from the establishment of database to October in 2013. Relevant reference lists were also screened. Two reviewers independently evaluated the methodological quality of included studies. We also conducted the meta-analysis. Thirteen trials involving 1

169 patients were included. There was no trial reported death or disability at the end of follow-up period. Meta-analysis of 4 trials (n=371) showed that there was no significant difference in the reduction of mortality [risk ratios (RR)=0.48

95% confidence intervals (CI

0.21

1.13)

P=0.09] between the Xingnaojing and control groups. Meta-analysis of 5 trials (n=359) showed that there was significant difference in reducing the major neurodevelopmental disability [RR=0.36

95% CI (0.19

0.66)

P=0.001]. Meta-analysis of 6 trials (n=447) showed that there was significant difference in the author self-defined symptom improvement [RR=1.25

95% CI (1.14

1.37)

P<0.01]. No fatal side-effects were reported. Based on the limited evidence

the routine use of Xingnaojing Injection for treatment of HIE in newborns is not recommended. Further well-conducted trials are justified.

Abstract

EMBASE

Cochrane Library

Cochrane Central

95% confidence intervals (CI

0.21

1.13)

P=0.09] between the Xingnaojing and control groups. Meta-analysis of 5 trials (n=359) showed that there was significant difference in reducing the major neurodevelopmental disability [RR=0.36

95% CI (0.19

0.66)

P=0.001]. Meta-analysis of 6 trials (n=447) showed that there was significant difference in the author self-defined symptom improvement [RR=1.25

95% CI (1.14

1.37)

P<0.01]. No fatal side-effects were reported. Based on the limited evidence

the routine use of Xingnaojing Injection for treatment of HIE in newborns is not recommended. Further well-conducted trials are justified.

关键词

Chinese Herbal MedicinenewbornsHypoxic Ischemic Encephalopathysystematic review

Keywords

Chinese Herbal MedicinenewbornsHypoxic Ischemic Encephalopathysystematic review

references

van Handel M, Swaab H, de Vries LS, Jongmans MJ. Long-term cognitive and behavioral consequences of neonatal encephalopathy following perinatal asphyxia: a review. Eur J Pediatr 2007;166:645–654.

Kurinczuk JJ, White-Koning M, Badawi N. Epidemiology of neonatal encephalopathy and hypoxic-ischemic encephalopathy. Early Hum Dev 2010;86:329–338.

Wong V, Cheuk DK, Chu V. Acupuncture for hypoxic ischemic encephalopathy in neonates. Cochrane Database Syst Rev 2013;1:1–20.

Shankaran S, Pappas A, McDonald SA, Vohr BR, Hintz SR, Yolton K, et al. Childhood outcomes after hypothermia for neonatal encephalopathy. N Engl J Med 2013;366:2085–2092.

Jacobs SE, Berg M, Hunt R, Tarnow-Mordi WO, Inder TE, Davis PG. Cooling for newborns with hypoxic ischemic encephalopathy. Cochrane Database Syst Rev 2013;3:1–112.

Xu J, Yang Y. Traditional Chinese medicine in the Chinese health care system. Health Policy 2009;90:133–139.

Xue CC, Zhang AL, Greenwood KM, Lin V, Story DF. Traditional chinese medicine: an update on clinical evidence. J Altern Complement Med 2010;16:301–312.

Manheimer E, Wieland S, Kimbrough E, Cheng K, Berman BM. Evidence from the Cochrane Collaboration for traditional Chinese medicine therapies. J Altern Complement Med 2009;15:1001–1014.

Lin S, Wu B, Liu M. Xingnaojing Injection for intracerebral hemorrhage: a systematic review. Chin J Evid-Based Med (Chin) 2008;8:93–96.

Huang WJ, Chen SQ, Wang WT, Li HP, Cheng JY, Zhao CH, et al. Effect of Xingnaojing Injection on metabolism of arachidonic acid in rabbits following cerebral ischemia reperfusion injury. Chin J Clin Pharm Ther (Chin) 2005;10:1171–1173.

Liu Y, Sun JN, Dong SF, Liu M, Zhang Y, Du SY. Protective effect of solid preparation of Xingnaojing from neurological defect and oxidative damage in pMCAO model rats in early convalescence. Chin J Exp Tradit Med Formulae (Chin) 2012;18:175–180.

Wang SJ, Yuan XM, Yan DH, Wu Q, Que X, Wang W, et al. Traditional Chinese medicine Xingnaojing in the treatment of spontaneously hypertensive stroke in rats. J Tradit Chin Med (Chin) 1998;39:303–304.

Yang YH, Ding R, Liu F, Zhai SD. Xingnaojing in the treatment of acute alcohol intoxication: a systematic review. Chin J Evid-Based Med (Chin) 2009;9:957–963.

Xu FL, Gao LX, Wu TX, Ding JH. Clinical efficacy and safty of Xingnaojing Injection for cerebral infarction: a systematic review. Chin J Evid-Based Med (Chin) 2005;5:549–554.

Sarnat HB, Sarnat MS. Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study. Arch Neurol 1976;33:696–705.

Julian PT Higgins, Sally Green, eds. Cochrane handbook for systematic reviews of interventions. version 5.1.0. Available at: http://www.cochranehandbookorg 20–8.

Chen LG. Treatment of 44 cases of neonatal hypoxic ischemic encephalopathy with combination of Chinese traditional and Western medicine. Shaanxi J Tradit Chin Med (Chin) 2001;12–715.

Yu XY. The effects of Xingnaojing and early intervention on neonatal hypoxia ischemic encephalopathy. Central Plains Med J (Chin) 2007;34(3):48.

Xu DJ, Zhang XP. Observation of 32 cases of Xingnaojing Injection in the treatment of neonatal hypoxic ischemic encephalopathy. J Pract Tradit Chin Med (Chin) 2002;18:34–35.

Yang FY, Wang PB, Chen X. Xingnaojing Injection in treatment of 30 cases of neonatal hypoxic ischemic encephalopathy. Modern Med Health (Chin) 2001;17–1011.

Cui N. Effect of Xingnaojing Injection in the treatment of 30 cases of neonatalhypoxic ischemic encephalopathy. Med J Commun (Chin) 2001;15–563.

Li GL. The effect of Xingnaojing for neonatal hypoxicischemic encephalopathy. Qinghai Med J (Chin) 2008; 38(9):27–28.

Mei H, Fu L, Ma JZ, Wang l. The effecacy of Xingnaojing for the treatment of consciousness disorders of neonates with hypoxic ischemic encephalopathy. Chin J Misdiagn (Chin) 2008;8:4571–4572.

Xu HQ, Chen LG. Effect of Xingnaojing Injection combined with conventional Western medicine for treating neonates with hypoxic ischemic encephalopathy. Clin J Anhui Tradit Chin Med (Chin) 2001;13:259–260.

Jia ML. Clinical observation of 44 cases of Xingnaojing Injection in the treatment of neonatal hypoxic ischemic encephalopathy. Chin J Coal Industry Med (Chin) 2002;5:165–166.

Wang XH, Feng YY, Yue W. Xingnaojing Injection in the treatment of moderate and severe neonatal hypoxic ischemic encephalopathy. Sichuan J Tradit Chin Med (Chin) 2003;21(12):60–61.

Li XL, Guo SJ, Li XQ, Lin YB. Clinical effect of Xingnaojing combined with naloxone on moderate and severe ischemichypoxic encephalopathy in the newborn. Chin Med Digest (Pediatrics, Chin) 2007;26:89–91.

Liu YZ. The effect of Xingnaojing combined with naloxone in treatment of neonatal hypoxic ischemic encephalopathy. Henan J Pract Neurons Dis 2003;6(6):66.

Wen YX, Wang WH, Yang CF. The effect of treating 40 cases of neonates with hypoxic ischemic encephalopathy. Chin J Primary Med Pharm 2007;14–853.

FULL TEXT LINK

More>

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Is Chinese herbal medicine effective for elderly isolated systolic hypertension? A systematic review and meta-analysis

Systematic review on randomized controlled trials of coronary heart disease complicated with depression treated with Chinese herbal medicines

A systematic review and meta-analysis of type 2 diabetes mellitus treatment based on the “three-typed syndrome differentiation” theory in Chinese medicine

Catgut Implantation at acupoints for allergic rhinitis: A systematic review

Development is a high level inheritance for China Time-honored Brand products