Effect of Huanshuai Recipe Oral Liquid (缓衰口服液) on renal dysfunction progression in patients with atherosclerotic renal artery stenosis

Xiu-juan Wang; Xiang-rong Rao; Shen Li; Li Wang; Chang Liu; Gai-hua Zhang; Dong-yan Han; Yu Zhao; Nan-nan Zhang; Xue-xia Li; Shuai Chen

doi:10.1007/s11655-015-2046-0

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Effect of Huanshuai Recipe Oral Liquid (缓衰口服液) on renal dysfunction progression in patients with atherosclerotic renal artery stenosis

OriginalPaper | Updated：2021-08-27

- Effect of Huanshuai Recipe Oral Liquid (缓衰口服液) on renal dysfunction progression in patients with atherosclerotic renal artery stenosis
- Effect of Huanshuai Recipe Oral Liquid (缓衰口服液) on renal dysfunction progression in patients with atherosclerotic renal artery stenosis
- 中国结合医学杂志（英文版） 2015年21卷第11期页码：811-816
- Affiliations：
  
  1. Department of Nephropathy, Guang’anmen Hospital, China Academy of Chinese Medical Sciences,Beijing,China
  2. Department of Nephropathy, Beijing Fangshan Hospital of Traditional Chinese Medicine,Beijing,China
  3. Department of Nephropathy, The Second People’s Hospital of Zhuhai,Guangdong Province,Zhuhai,China
  4. Department of Nephropathy, Beijing Miyun Hospital of Traditional Chinese Medicine,Beijing,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-015-2046-0
  中图分类号：
- 纸质出版日期：2015，
  
  网络出版日期：2015-4-6，
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Wang, Xj., Rao, Xr., Li, S. et al. Effect of Huanshuai Recipe Oral Liquid (缓衰口服液) on renal dysfunction progression in patients with atherosclerotic renal artery stenosis., Chin. J. Integr. Med. 21, 811–816 (2015). https://doi.org/10.1007/s11655-015-2046-0

Xiu-juan Wang, Xiang-rong Rao, Shen Li, et al. Effect of Huanshuai Recipe Oral Liquid (缓衰口服液) on renal dysfunction progression in patients with atherosclerotic renal artery stenosis[J]. Chinese Journal of Integrative Medicine, 2015,21(11):811-816.
Wang, Xj., Rao, Xr., Li, S. et al. Effect of Huanshuai Recipe Oral Liquid (缓衰口服液) on renal dysfunction progression in patients with atherosclerotic renal artery stenosis., Chin. J. Integr. Med. 21, 811–816 (2015). https://doi.org/10.1007/s11655-015-2046-0 DOI：

Xiu-juan Wang, Xiang-rong Rao, Shen Li, et al. Effect of Huanshuai Recipe Oral Liquid (缓衰口服液) on renal dysfunction progression in patients with atherosclerotic renal artery stenosis[J]. Chinese Journal of Integrative Medicine, 2015,21(11):811-816. DOI： 10.1007/s11655-015-2046-0.

摘要

To investigate the effect of Huanshuai Recipe Oral Liquid (缓衰口服液

HSR) on retarding the progression of renal dysfunction in patients with atherosclerotic renal artery stenosis (ARAS). A total of 52 ARAS patients with the Chinese medicine (CM) syndrome of qi deficiency and blood stasis

phlegm and dampness retention were recruited and randomly assigned into the treatment group (36 cases) and the control group (16 cases). Both groups received a basic treatment (high-quality low-protein diet

blood pressure control

lipid-lowering

correcting the acidosis

etc.). In addition

the treatment group received 20 mL HSR and the control group received placebo

3 times a day for 6 months. Renal function (serum creatinine

blood urea nitrogen and uric acid) and blood lipids (cholesterol

triglycerides and low density lipoprotein) were examined monthly. The estimated glomerular fifiltration rate (eGFR) and CM syndrome score were compared between groups. After treatment

compared with the control group

the serum creatinine level

uric acid level and CM syndrome score of the treatment group were signifificantly decreased (P<0.05 or P<0.01)

and the eGFR in the treatment group were significantly increased (P<0.05). HSR can effectively improve the renal function and clinical symptoms of ARAS patients.

Abstract

To investigate the effect of Huanshuai Recipe Oral Liquid (缓衰口服液

blood pressure control

lipid-lowering

correcting the acidosis

etc.). In addition

the treatment group received 20 mL HSR and the control group received placebo

3 times a day for 6 months. Renal function (serum creatinine

blood urea nitrogen and uric acid) and blood lipids (cholesterol

triglycerides and low density lipoprotein) were examined monthly. The estimated glomerular fifiltration rate (eGFR) and CM syndrome score were compared between groups. After treatment

compared with the control group

the serum creatinine level

uric acid level and CM syndrome score of the treatment group were signifificantly decreased (P<0.05 or P<0.01)

and the eGFR in the treatment group were significantly increased (P<0.05). HSR can effectively improve the renal function and clinical symptoms of ARAS patients.

关键词

atherosclerotic renal artery stenosisHuanshuai Recipe Oral LiquidRenal DysfunctionChinese Medicine

Keywords

atherosclerotic renal artery stenosisHuanshuai Recipe Oral LiquidRenal DysfunctionChinese Medicine

references

Seddon M, Saw J. Atherosclerotic renal artery stenosis: review of pathophysiology, clinical trial evidence, and management strategies. Can J Cardiol 2011;27:468–480.

Wang F, Wang M, Wang HY. Patients with atherosclerotic renal artery stenosis prevalence survey. Chin J Nephrol (Chin) 2005;21:139–142.

Mailloux LU, Napolitano B, Bellucci AG, Vernace M, Wilkes BM, Mossey RT. Renal vascular disease causing endstage renal disease, incidence, clinical correlates, and outcomes: a 20-year clinical experience. Am J Kidney Dis 1994;24:622–629.

de Mast Q, Beutler JJ. The prevalence of atherosclerotic renal artery stenosisi in risk groups: a systematic literature review. J Hypertens 2009;27:1333–1340.

Kalra PA, Guo H, Kausz AT, Gilbertson DT, Liu JN, Chen SC, et al. Atherosclerotic renovascular disease in United States patients aged 67 years or older: risk factors, revascularization, and prognosis. Kidney Int 2005;68:293–301.

Rao XR, Zhang NN, Li S. Preliminary research of syndrome of traditional Chinese medicine on atherosclerotic renal artery stenosis. Chin J Integr Tradit West Med (Chin) 2010;11:125–127.

Li S, Rao XR, Song JY, Meng LQ, Qu L, Li XM. Effects of Huanshuai Recipe Oral Liquid on restructuring glomerular microvasculature and expression of vascular endothelial growth factor in subtotal nephrectomized rats. Chin J Integr Med 2010;16:239–246.

Li S, Rao XR, Dai XW. The clinical observation of longterm curative efficacy of Huanshuai Recipe Oral Solution in treating 35 patients with chronic renal failure. J Tradit Chin Med (Chin) 2001;42:164–166.

Rundback JH, Sacks D, Kent KC, Cooper C, Jones D, Murphy T, et al. American Heart Association. Guidelines for the reporting of renal artery revascularization in clinical trials. Circulation 2002;106:1572–1585.

National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 2002;39(2 Suppl 1):S1-S266.

Zheng XY, ed. Guiding principles for clinical research on new drugs of traditional Chinese medicine (trial). Beijing: China Medical Science Press; 2002:163–168.

Mitch WE, Walser M, Buffington GA, Lemann J Jr. A simple method of estimating progression of chronic renal failure. Lancet 1976;2:1326–1328.

Lerman L, Textor S, Grande J. Mechanisms of tissue injury in renal artery stenosis: ischemia and beyond. Progr Cardiovasc Dis 2009;52:196–203.

The ASTRAL Investigators. Revascularization versus medical therapy for renal-artery stenosis. N Engl J Med 2009;361:1953-1962.

Sos TA. After ASTRAL and STAR—Whither renal artery stenting? Intervent Med Appl Sci 2010;2:153–158.

Dubel G, Murphy T. The role of percutaneous revascularization for renal artery stenosis. Vasc Med 2008;13:141–156.

Adalakha S, Greco B, Dart R, Shepherd A, Murphy T, Jamerson K, et al. Pressure control in patients with renal artery stenosis, preliminary results of the CORAL clinical trial. Circulation 2010;122:A17234.

Zhang NN, Rao XR. Therapy option for renal artery stenosis: percutaneous revascularization or medical treatment? Chin J Integr Tradit West Nephrol (Chin) 2009;10:261–263.

Li XX, Rao XR. Treatment of atherosclerotic renal artery stenosis. Chin J Inform Tradit Chin Med (Chin) 2009;2:90–91.

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