Vasorelaxation effect of gastrodin on isolated thoracic aorta rings of rats

Yuan-long Xie; Min Zhou; Hui-hao Ma; Xiang Wang; Ju-ju Liu

doi:10.1007/s11655-015-2082-9

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Vasorelaxation effect of gastrodin on isolated thoracic aorta rings of rats

OriginalPaper | Updated：2021-08-27

- Vasorelaxation effect of gastrodin on isolated thoracic aorta rings of rats
- Vasorelaxation effect of gastrodin on isolated thoracic aorta rings of rats
- 中国结合医学杂志（英文版） 2015年21卷第12期页码：944-948
- Affiliations：
  
  Department of Physiology, Medical Science College, China Three Gorges University,Hubei Province,Yichang,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-015-2082-9
  中图分类号：
- 纸质出版日期：2015，
  
  网络出版日期：2015-5-9，
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Xie, Yl., Zhou, M., Ma, Hh. et al. Vasorelaxation effect of gastrodin on isolated thoracic aorta rings of rats., Chin. J. Integr. Med. 21, 944–948 (2015). https://doi.org/10.1007/s11655-015-2082-9

Yuan-long Xie, Min Zhou, Hui-hao Ma, et al. Vasorelaxation effect of gastrodin on isolated thoracic aorta rings of rats[J]. Chinese Journal of Integrative Medicine, 2015,21(12):944-948.
Xie, Yl., Zhou, M., Ma, Hh. et al. Vasorelaxation effect of gastrodin on isolated thoracic aorta rings of rats., Chin. J. Integr. Med. 21, 944–948 (2015). https://doi.org/10.1007/s11655-015-2082-9 DOI：

Yuan-long Xie, Min Zhou, Hui-hao Ma, et al. Vasorelaxation effect of gastrodin on isolated thoracic aorta rings of rats[J]. Chinese Journal of Integrative Medicine, 2015,21(12):944-948. DOI： 10.1007/s11655-015-2082-9.

摘要

To study the effect of gastrodin on isolated thoracic aorta rings of rats and to investigate the potential mechanism. A perfusion model of isolated thoracic aorta rings of rats was applied. The effect of cumulative gastrodin (5

100

150

200

and 250 μmol/L) on endothelium-intact aorta rings was investigated. The same procedure was applied to observe the effect of gastrodin on endothelium-intact/denuded aorta rings pre-contracted with 10-6 mol/L phenylephrine hydrochloride (PE). The aorta rings incubated by 200 mmol/L gastrodin in the Ca2+-free (K-H) solution was contracted by using PE. The effect of 200 mmol/L gastrodin on endothelium-denuded aorta rings pre-contracted with 60 mmol/L KCl was also observed. Compared with the denuded gastrodin group

the intact gastrodin group could significantly relax the PE-contracted aorta rings (P<0.01). In Ca2+-free (K-H) solution KHS

the PE-induced contraction rate of aorta rings pre-incubated by gastrodin was 6.5%±0.7%

which was significantly less than the control group (11.8%±0.9%

P<0.01). However

after 3 mmol/L CaCl2 was added

the Ca2+-induced contraction in the gastrodin group (51.7%±2.4%) was similar to that in the control group (49.8%±2.8%). The contractile rate of rings in the KCl-contracted gastrodin group (96.3%±0.6%) was not significantly different from that in the control group (96.8%±1.2%). Gastrodin has the effect of vasorelaxation on isolated thoracic aorta rings of rats. The mechanism of the vasorelaxation of gastrodin may mainly work through the inhibition of inositol 1

5-trisphosphosphate receptor on the sarcoplasmic reticulum of the arterial smooth muscle

which leads to the reduction of the Ca2+ released from the sarcoplasmic reticulum.

Abstract

100

150

200

the intact gastrodin group could significantly relax the PE-contracted aorta rings (P<0.01). In Ca2+-free (K-H) solution KHS

the PE-induced contraction rate of aorta rings pre-incubated by gastrodin was 6.5%±0.7%

which was significantly less than the control group (11.8%±0.9%

P<0.01). However

after 3 mmol/L CaCl2 was added

5-trisphosphosphate receptor on the sarcoplasmic reticulum of the arterial smooth muscle

which leads to the reduction of the Ca2+ released from the sarcoplasmic reticulum.

关键词

gastrodinthoracic aorta ringvasorelaxationChinese Medicine

Keywords

gastrodinthoracic aorta ringvasorelaxationChinese Medicine

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