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Xinfeng Capsule (新风胶囊) for the treatment of rheumatoid arthritis patients with decreased pulmonary function — A randomized controlled clinical trial
Xinfeng Capsule (新风胶囊) for the treatment of rheumatoid arthritis patients with decreased pulmonary function — A randomized controlled clinical trial
- 中国结合医学杂志（英文版） 2016年22卷第3期 页码：168-176
- Affiliations：
Department of Rheumatology, The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei,China
- Author bio：
- Funds：Supported by the Natural Science Foundation of China (No. 81403388, 81173211);Anhui Province Natural Science Fund Project of China (No. 1508085QH159);Key Discipline of Chinese Bi Disease Science Projects, State Administration of Traditional Chinese Medicine (No. [2009]30);Anhui College of Traditional Chinese Medicine Science and Technology Innovation Team Project (No. 2010TD005);and the Fund Supported by Anhui University of Chinese Medicine University (No. 2014qn025)
DOI：10.1007/s11655-015-2093-6
中图分类号：纸质出版日期：2016，
网络出版日期：2016-1-27，
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Wan, L., Liu, J., Huang, Cb. et al. Xinfeng Capsule (新风胶囊) for the treatment of rheumatoid arthritis patients with decreased pulmonary function — A randomized controlled clinical trial., Chin. J. Integr. Med. 22, 168–176 (2016). https://doi.org/10.1007/s11655-015-2093-6
Lei Wan, Jian Liu, Chuan-bing Huang, et al. Xinfeng Capsule (新风胶囊) for the treatment of rheumatoid arthritis patients with decreased pulmonary function — A randomized controlled clinical trial[J]. Chinese Journal of Integrative Medicine, 2016,22(3):168-176.
Wan, L., Liu, J., Huang, Cb. et al. Xinfeng Capsule (新风胶囊) for the treatment of rheumatoid arthritis patients with decreased pulmonary function — A randomized controlled clinical trial., Chin. J. Integr. Med. 22, 168–176 (2016). https://doi.org/10.1007/s11655-015-2093-6 DOI：
Lei Wan, Jian Liu, Chuan-bing Huang, et al. Xinfeng Capsule (新风胶囊) for the treatment of rheumatoid arthritis patients with decreased pulmonary function — A randomized controlled clinical trial[J]. Chinese Journal of Integrative Medicine, 2016,22(3):168-176. DOI： 10.1007/s11655-015-2093-6.
摘要
To determine the effectiveness and safety of Xinfeng Capsules (新风胶囊
XFC) for the treatment of rheumatoid arthritis (RA) patients with decreased pulmonary function. This was a randomized controlled clinical trial of 80 RA patients. Participants were assigned to the trial group (40 cases) and the control group (40 cases) by block randomization. The trial group was treated with XFC
three pills each time three times daily for 2 months. The control group was treated with tripterygium glycoside (TPT)
two pills each time three times daily for 2 months. Both groups were followed up after 2 months. The clinical effects
changes in joint and pulmonary function
and quality of life before and after treatment were observed; safety indices were also evaluated. Pain
swelling
tenderness
and duration of morning stiffness of joints were obviously decreased after treatment in both the trial and the control groups compared with baseline (P<0.01). Compared with before treatment
hand grip strength increased significantly after treatment in the trial group (P=0.0000); pulmonary function parameters such as forced expiratory volume in the first second of expiration/forced vital capacity (FEV1/FVC)
50% of the expiratory flow of forced vital capacity (FEF50)
carbon monoxide diffusing capacity (DLco) were increased (P<0.01 or P<0.05); measures of quality of life such as role-physical
body pain
vitality and mental health were also improved after treatment in the trial group (all P<0.05). Joint swelling in the trial group decreased compared with the control group (P=0.0043)
while hand grip strength was increased after treatment (P=0.0000). The increase in FEF50
DLco
and the dimensions of quality of life such as vitality and mental health were all significantly greater in the trial group than the control group (P<0.05 or P<0.01). XFC not only relieved joint pain in RA patients
but also significantly improved the ventilation and diffusion function of the lungs. Therefore
XFC could improve the whole body function and enhance the quality of life of RA patients.
Abstract
To determine the effectiveness and safety of Xinfeng Capsules (新风胶囊
XFC) for the treatment of rheumatoid arthritis (RA) patients with decreased pulmonary function. This was a randomized controlled clinical trial of 80 RA patients. Participants were assigned to the trial group (40 cases) and the control group (40 cases) by block randomization. The trial group was treated with XFC
three pills each time three times daily for 2 months. The control group was treated with tripterygium glycoside (TPT)
two pills each time three times daily for 2 months. Both groups were followed up after 2 months. The clinical effects
changes in joint and pulmonary function
and quality of life before and after treatment were observed; safety indices were also evaluated. Pain
swelling
tenderness
and duration of morning stiffness of joints were obviously decreased after treatment in both the trial and the control groups compared with baseline (P<0.01). Compared with before treatment
hand grip strength increased significantly after treatment in the trial group (P=0.0000); pulmonary function parameters such as forced expiratory volume in the first second of expiration/forced vital capacity (FEV1/FVC)
50% of the expiratory flow of forced vital capacity (FEF50)
carbon monoxide diffusing capacity (DLco) were increased (P<0.01 or P<0.05); measures of quality of life such as role-physical
body pain
vitality and mental health were also improved after treatment in the trial group (all P<0.05). Joint swelling in the trial group decreased compared with the control group (P=0.0043)
while hand grip strength was increased after treatment (P=0.0000). The increase in FEF50
DLco
and the dimensions of quality of life such as vitality and mental health were all significantly greater in the trial group than the control group (P<0.05 or P<0.01). XFC not only relieved joint pain in RA patients
but also significantly improved the ventilation and diffusion function of the lungs. Therefore
XFC could improve the whole body function and enhance the quality of life of RA patients.
关键词
rheumatoid arthritispulmonary functionquality of lifeXinfeng Capsuleclinical trial
Keywords
rheumatoid arthritispulmonary functionquality of lifeXinfeng Capsuleclinical trial
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