Biotransformation effect of Bombyx Mori L. may play an important role in treating diabetic nephropathy

Lei Zhang; La Zhang; Yin Li; Xin-feng Guo; Xu-sheng Liu

doi:10.1007/s11655-015-2128-z

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Biotransformation effect of Bombyx Mori L. may play an important role in treating diabetic nephropathy

ReviewPaper | Updated：2021-08-27

- Biotransformation effect of Bombyx Mori L. may play an important role in treating diabetic nephropathy
- Biotransformation effect of Bombyx Mori L. may play an important role in treating diabetic nephropathy
- 中国结合医学杂志（英文版） 2016年22卷第11期页码：872-879
- Affiliations：
  
  1. Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine,Guangzhou,China
  2. Guangzhou University of Chinese Medicine,Guangzhou,China
  3. Evidence-Based Medicine and Clinical Research Service Team, Guangdong Provincial Hospital of Chinese Medicine,Guangzhou,China
- Author bio：
- Funds：
  
  Supported by the Industry Special Scientific Research Project of the State Chinese Medicine Administration Bureau (No. 201007005 and No. 201407005)
- DOI：10.1007/s11655-015-2128-z
  中图分类号：
- 纸质出版日期：2016，
  
  网络出版日期：2015-12-19，
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Zhang, L., Zhang, L., Li, Y. et al. Biotransformation effect of Bombyx Mori L. may play an important role in treating diabetic nephropathy., Chin. J. Integr. Med. 22, 872–879 (2016). https://doi.org/10.1007/s11655-015-2128-z

Lei Zhang, La Zhang, Yin Li, et al. Biotransformation effect of Bombyx Mori L. may play an important role in treating diabetic nephropathy[J]. Chinese Journal of Integrative Medicine, 2016,22(11):872-879.
Zhang, L., Zhang, L., Li, Y. et al. Biotransformation effect of Bombyx Mori L. may play an important role in treating diabetic nephropathy., Chin. J. Integr. Med. 22, 872–879 (2016). https://doi.org/10.1007/s11655-015-2128-z DOI：

Lei Zhang, La Zhang, Yin Li, et al. Biotransformation effect of Bombyx Mori L. may play an important role in treating diabetic nephropathy[J]. Chinese Journal of Integrative Medicine, 2016,22(11):872-879. DOI： 10.1007/s11655-015-2128-z.

摘要

Compared with herbal drugs

medicine processed from animals (animal medicine) was thought to have more bioactive substances and higher activities. Biotransformation effect often plays an important role in their effect. However

researches about effect of animal medicine on diabetic nephropathy and applying animal medicine as natural bio-transformer were seldom reported. The purpose of this paper was to reveal the use of Bombyx Mori L. on diabetic nephropathy from ancient to modern times. The classical literature indicated that Saosi Decoction (缫丝汤)

which contains Bombyx Mori L. or silkworm cocoon

was applied to treat disorders congruent with modern disease diabetic nephropathy from the Ming to Qing Dynasty in ancient China. Modern studies showed that Bombyx Mori L. contains four main active constituents. Among these

1-deoxynojirimycin (1-DNJ) and quercetin showed promising potential to be new agents in diabetic nephropathy treatment. The concentrations of 1-DNJ and the activities of quercetin in Bombyx Mori L. are higher than in mulberry leaves

because of the biotransformation in the Bombyx Mori L. body. However

these specifific components need further human and mechanistic studies to determine their therapeutic potential for this challenging condition.

Abstract

Compared with herbal drugs

medicine processed from animals (animal medicine) was thought to have more bioactive substances and higher activities. Biotransformation effect often plays an important role in their effect. However

which contains Bombyx Mori L. or silkworm cocoon

because of the biotransformation in the Bombyx Mori L. body. However

these specifific components need further human and mechanistic studies to determine their therapeutic potential for this challenging condition.

关键词

diabetic nephropathyBombyx Mori L.1-deoxynojirimycinQuercetinbiotransformationChinese Medicine

Keywords

diabetic nephropathyBombyx Mori L.1-deoxynojirimycinQuercetinbiotransformationChinese Medicine

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