Effect of Zataria multiflora Extract on Total and Differential White Blood Cell Count and Endothelin Level in Blood of Ovalbumin Sensitized Guinea Pigs
Back to article page
Original Article|Updated:2021-08-23
|
Effect of Zataria multiflora Extract on Total and Differential White Blood Cell Count and Endothelin Level in Blood of Ovalbumin Sensitized Guinea Pigs
Effect of Zataria multiflora Extract on Total and Differential White Blood Cell Count and Endothelin Level in Blood of Ovalbumin Sensitized Guinea Pigs
Chinese Journal of Integrative Medicine2020年26卷第8期 页码:604-608
Affiliations:
1.Neurogenic Inflammation Research Center and Department of Physiology, School of Medicine, Mashhad, Iran
2.Department of Biology, Payam Noor University, Tehran, Iran
Author bio:
Correspondence to: Dr. Mohammad Hossein Boskabady, E-mail:boskabadymh@mums.ac.ir, E-mail:mhboskabady@hotmail.com
Funds:
Research Department of Mashhad University of Medical Sciences(89431)
Mohammad Hossein Boskabady, Sediqeh Jalali. Effect of Zataria multiflora Extract on Total and Differential White Blood Cell Count and Endothelin Level in Blood of Ovalbumin Sensitized Guinea Pigs[J]. Chinese Journal of Integrative Medicine, 2020,26(8):604-608.
Mohammad Hossein Boskabady, Sediqeh Jalali. Effect of Zataria multiflora Extract on Total and Differential White Blood Cell Count and Endothelin Level in Blood of Ovalbumin Sensitized Guinea Pigs[J]. Chinese Journal of Integrative Medicine, 2020,26(8):604-608.
Mohammad Hossein Boskabady, Sediqeh Jalali. Effect of Zataria multiflora Extract on Total and Differential White Blood Cell Count and Endothelin Level in Blood of Ovalbumin Sensitized Guinea Pigs[J]. Chinese Journal of Integrative Medicine, 2020,26(8):604-608. DOI: 10.1007/s11655-015-2129-y.
Mohammad Hossein Boskabady, Sediqeh Jalali. Effect of Zataria multiflora Extract on Total and Differential White Blood Cell Count and Endothelin Level in Blood of Ovalbumin Sensitized Guinea Pigs[J]. Chinese Journal of Integrative Medicine, 2020,26(8):604-608. DOI: 10.1007/s11655-015-2129-y.
Effect of Zataria multiflora Extract on Total and Differential White Blood Cell Count and Endothelin Level in Blood of Ovalbumin Sensitized Guinea Pigs
摘要
Abstract
Objective:
2
To investigate the effect of hydro-ethanolic extract of
Zataria multiflora
(
Z. multiflora
) on endothelin level
total and differential white blood cells (WBC) count of sensitized guinea pigs.
Methods:
2
Five groups of guinea pigs sensitized to ovalbumin (OA) were given drinking water alone (group S)
drinking water containing three concentrations of
Z. multiflora
(0.2
0.4 and 0.8 mg/mL as groups S+Z1
S+Z2 and S+Z3) and dexamethasone (group S+D)
n
=6 for each group. The endothelin levels as well as total and differential WBC count in blood of sensitized and control guinea pigs were evaluated using enzyme linked immunosorbent assay method
and hemocytometer and Wright-Giemsa's staining of blood sample smear respectively.
Results:
2
Blood endothelin levels
total and most differential WBC count were increased but lymphocytes decreased in sensitized animals compared to controls (all
P
<
0.01). In groups S+D
S+Z2 and S+Z3 endothelin level
total and differential WBC counts were significantly improved compared with group S (
P
<
0.01). Although
all measured parameters in group S+Z1 was lower than group S+D (
P
<
0.01)
some parameters in group S+Z3 were greater than in group S+D (
P
<
0.05 to
P
<
0.01).
Conclusion:
2
The results showed an anti-inflammatory effect of
Z. multiflora
extract in sensitized guinea pigs
which may suggest a therapeutic potential for the plant on asthma.