Effects of Korean red ginseng on semen parameters in male infertility patients: A randomized, placebo-controlled, double-blind clinical study

Hyun Jun Park; Sangmin Choe; Nam Cheol Park

doi:10.1007/s11655-015-2139-9

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Effects of Korean red ginseng on semen parameters in male infertility patients: A randomized, placebo-controlled, double-blind clinical study

OriginalPaper | Updated：2021-08-27

- Effects of Korean red ginseng on semen parameters in male infertility patients: A randomized, placebo-controlled, double-blind clinical study
- Effects of Korean red ginseng on semen parameters in male infertility patients: A randomized, placebo-controlled, double-blind clinical study
- 中国结合医学杂志（英文版） 2016年22卷第7期页码：490-495
- Affiliations：
  
  1. Department of Urology, Pusan National University School of Medicine, Busan, Republic of Korea
  2. Medical Research Institute of Pusan National University Hospital, Busan, Republic of Korea
  3. Division of Clinical Pharmacology, Clinical Trial Center, Pusan National University Hospital, Busan, Republic of Korea
- Author bio：
- Funds：
  
  Supported by a 2010 grant from the Korean Society for Ginseng funded by the Korean Ginseng Corporation, Republic of Korea
- DOI：10.1007/s11655-015-2139-9
  中图分类号：
- 纸质出版日期：2016，
  
  网络出版日期：2015-5-12，
Scan for full text
Park, H.J., Choe, S. & Park, N.C. Effects of Korean red ginseng on semen parameters in male infertility patients: A randomized, placebo-controlled, double-blind clinical study., Chin. J. Integr. Med. 22, 490–495 (2016). https://doi.org/10.1007/s11655-015-2139-9

Hyun Jun Park, Sangmin Choe, Nam Cheol Park. Effects of Korean red ginseng on semen parameters in male infertility patients: A randomized, placebo-controlled, double-blind clinical study[J]. Chinese Journal of Integrative Medicine, 2016,22(7):490-495.
Park, H.J., Choe, S. & Park, N.C. Effects of Korean red ginseng on semen parameters in male infertility patients: A randomized, placebo-controlled, double-blind clinical study., Chin. J. Integr. Med. 22, 490–495 (2016). https://doi.org/10.1007/s11655-015-2139-9 DOI：

Hyun Jun Park, Sangmin Choe, Nam Cheol Park. Effects of Korean red ginseng on semen parameters in male infertility patients: A randomized, placebo-controlled, double-blind clinical study[J]. Chinese Journal of Integrative Medicine, 2016,22(7):490-495. DOI： 10.1007/s11655-015-2139-9.

摘要

To investigate the effects of Korean red ginseng (KRG) on semen parameters in male infertility patients in a randomized

double-blind

placebo-controlled study. A total of 80 male infertility patients with varicocele were recruited from April 2011 to February 2012. The subjects were then divided into the following four groups: non-varicocelectomy (V)+placebo (P) group

V+P group

non-V+KRG group (1.5-g KRG daily)

and V+KGR group (1.5-g KRG daily). Semen analysis was performed and hormonal levels were measured in each treatment arm after 12 weeks. All groups but not the non-V+P group

showed significant improvements in sperm concentrations

motility

morphology

and viability at the end of the study. However

there were no significant differences in serum follicle-stimulating hormone

luteinizing hormone

and testosterone among groups. The incidence of adverse events was low

and all events were assumed to be unrelated to the treatments administered. Although the exact mechanism by which KRG improves spermatogenesis remains unclear

KRG may be a useful agent for the treatment of male infertility. Nevertheless

additional studies to evaluate the optimal dose and duration of treatment are needed.

Abstract

To investigate the effects of Korean red ginseng (KRG) on semen parameters in male infertility patients in a randomized

double-blind

V+P group

non-V+KRG group (1.5-g KRG daily)

and V+KGR group (1.5-g KRG daily). Semen analysis was performed and hormonal levels were measured in each treatment arm after 12 weeks. All groups but not the non-V+P group

showed significant improvements in sperm concentrations

motility

morphology

and viability at the end of the study. However

there were no significant differences in serum follicle-stimulating hormone

luteinizing hormone

and testosterone among groups. The incidence of adverse events was low

and all events were assumed to be unrelated to the treatments administered. Although the exact mechanism by which KRG improves spermatogenesis remains unclear

KRG may be a useful agent for the treatment of male infertility. Nevertheless

additional studies to evaluate the optimal dose and duration of treatment are needed.

关键词

Panax GinsengMale Infertilityspermatogenesis

Keywords

Panax GinsengMale Infertilityspermatogenesis

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