Oral oxymatrine preparation for chronic hepatitis B: A systematic review of randomized controlled trials

Wei-jiang Song; Jing Luo; Tong Wu; Shu-kun Yao

doi:10.1007/s11655-015-2143-0

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Oral oxymatrine preparation for chronic hepatitis B: A systematic review of randomized controlled trials

OriginalPaper | Updated：2021-08-27

- Oral oxymatrine preparation for chronic hepatitis B: A systematic review of randomized controlled trials
- Oral oxymatrine preparation for chronic hepatitis B: A systematic review of randomized controlled trials
- 中国结合医学杂志（英文版） 2016年22卷第2期页码：141-149
- Affiliations：
  
  1. Graduate School, Beijing University of Chinese Medicine,Beijing,China
  2. Department of Gastroenterology, China-Japan Friendship Hospital,Beijing,China
  3. Traditional Chinese Medicine Department of Rheumatism, China-Japan Friendship Hospital,Beijing,China
- Author bio：
- Funds：
  
  Supported by the National Key Scientific Project for New Drug Discovery and Development of China (No. 2012zx09103201)
- DOI：10.1007/s11655-015-2143-0
  中图分类号：
- 纸质出版日期：2016，
  
  网络出版日期：2015-5-26，
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Song, Wj., Luo, J., Wu, T. et al. Oral oxymatrine preparation for chronic hepatitis B: A systematic review of randomized controlled trials., Chin. J. Integr. Med. 22, 141–149 (2016). https://doi.org/10.1007/s11655-015-2143-0

Wei-jiang Song, Jing Luo, Tong Wu, et al. Oral oxymatrine preparation for chronic hepatitis B: A systematic review of randomized controlled trials[J]. Chinese Journal of Integrative Medicine, 2016,22(2):141-149.
Song, Wj., Luo, J., Wu, T. et al. Oral oxymatrine preparation for chronic hepatitis B: A systematic review of randomized controlled trials., Chin. J. Integr. Med. 22, 141–149 (2016). https://doi.org/10.1007/s11655-015-2143-0 DOI：

Wei-jiang Song, Jing Luo, Tong Wu, et al. Oral oxymatrine preparation for chronic hepatitis B: A systematic review of randomized controlled trials[J]. Chinese Journal of Integrative Medicine, 2016,22(2):141-149. DOI： 10.1007/s11655-015-2143-0.

摘要

To evaluate the efficacy and safety of oral oxymatrine preparation for the treatment of chronic hepatitis B (CHB). Randomized controlled trials (RCTs) on oral oxymatrine preparation in treating patients with CHB were retrieved until October 2013 by searching PubMed

the Cochrane Library

Embase and four Chinese databases

irrespective of language and publication status. Data extraction and data analyses were conducted according to the Cochrane standards. The risk of bias for each included trials and the quality of evidence on pre-specified outcomes were assessed. The RevMan software was used for statistical analyses. Totally 52 RCTs enrolling 5

227 participants were included

of which 51 RCTs were included in meta-analyses. Oral oxymatrine preparation including oxymatrine capsule and oxymatrine tablet were associated with statistically significant effect on the clearance of hepatitis B virus (HBV) DNA

HBV surface antigen and HBV e antigen

and were beneficial to the normalization of serum alanine aminotransferase and aspartate aminotransferase. Nevertheless

the overall methodological quality and the quality of evidence in the included trials were poor. In addition

safety of oral oxymatrine preparation was not confirmed. Oral oxymatrine preparation showed some potential benefits for patients with CHB. However

the overall quality of evidence was limited and the safety of oral oxymatrine preparation for CHB patients was still unproven. More high quality evidence from rigorously designed RCTs is warranted to support the clinical use of oral oxymatrine preparation for patients with CHB.

Abstract

the Cochrane Library

Embase and four Chinese databases

227 participants were included

HBV surface antigen and HBV e antigen

and were beneficial to the normalization of serum alanine aminotransferase and aspartate aminotransferase. Nevertheless

the overall methodological quality and the quality of evidence in the included trials were poor. In addition

safety of oral oxymatrine preparation was not confirmed. Oral oxymatrine preparation showed some potential benefits for patients with CHB. However

关键词

OxymatrinealkaloidChinese Herbhepatitis Bchronicsystematic review

Keywords

OxymatrinealkaloidChinese Herbhepatitis Bchronicsystematic review

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