Effect of Yangxinkang Tablets (养心康片) on chronic heart failure: A multi-center randomized double-blind placebo-controlled trial

Shao-xiang Xian; Zhong-qi Yang; Pei-hua Ren; Xiao-han Ye; Sui-lin Ye; Qing-hai Wang; Zhao-hui Wang; Shu-jing Shen; Xi-wen Huang

doi:10.1007/s11655-015-2170-x

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Effect of Yangxinkang Tablets (养心康片) on chronic heart failure: A multi-center randomized double-blind placebo-controlled trial

OriginalPaper | Updated：2021-08-27

- Effect of Yangxinkang Tablets (养心康片) on chronic heart failure: A multi-center randomized double-blind placebo-controlled trial
- Effect of Yangxinkang Tablets (养心康片) on chronic heart failure: A multi-center randomized double-blind placebo-controlled trial
- 中国结合医学杂志（英文版） 2015年21卷第10期页码：733-742
- Affiliations：
  
  1. The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Guangzhou,China
  2. The First Affiliated Hospital of Guangzhou Medical University,Guangzhou,China
  3. Dongguan Hospital of Traditional Chinese Medicine,Dongguan,China
  4. Guangzhou Hospital of Traditional Chinese Medicine,Guangzhou,China
  5. Guangdong Second Traditional Chinese Medicine Hospital,Guangzhou,China
- Author bio：
- Funds：
  
  Supported by Guangzhou Municipal Science and Technology Bureau Key Technology Research and Development of Pharmaceutical Preparations and Industrial Demonstration projects of China (No. 2008A1-E4101)
- DOI：10.1007/s11655-015-2170-x
  中图分类号：
- 纸质出版日期：2015，
  
  网络出版日期：2015-5-6，
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Xian, Sx., Yang, Zq., Ren, Ph. et al. Effect of Yangxinkang Tablets (养心康片) on chronic heart failure: A multi-center randomized double-blind placebo-controlled trial., Chin. J. Integr. Med. 21, 733–742 (2015). https://doi.org/10.1007/s11655-015-2170-x

Shao-xiang Xian, Zhong-qi Yang, Pei-hua Ren, et al. Effect of Yangxinkang Tablets (养心康片) on chronic heart failure: A multi-center randomized double-blind placebo-controlled trial[J]. Chinese Journal of Integrative Medicine, 2015,21(10):733-742.
Xian, Sx., Yang, Zq., Ren, Ph. et al. Effect of Yangxinkang Tablets (养心康片) on chronic heart failure: A multi-center randomized double-blind placebo-controlled trial., Chin. J. Integr. Med. 21, 733–742 (2015). https://doi.org/10.1007/s11655-015-2170-x DOI：

Shao-xiang Xian, Zhong-qi Yang, Pei-hua Ren, et al. Effect of Yangxinkang Tablets (养心康片) on chronic heart failure: A multi-center randomized double-blind placebo-controlled trial[J]. Chinese Journal of Integrative Medicine, 2015,21(10):733-742. DOI： 10.1007/s11655-015-2170-x.

摘要

To investigate the safety and efficacy of Yangxinkang Tablets (养心康片) in patients with chronic heart failure (CHF) and syndrome of qi and yin deficiency

blood stasis

and water retention. In a double-blinded

randomized

placebo-controlled

multicenter clinical trail

228 patients with CHF New York Heart Association (NYHA) class II or III in stage C were assigned by randomized block method to two groups in a 1:1 ratio to undergo either conventional Western treatment or conventional treatment plus Yangxinkang Tablets for 4 weeks. The outcome measure were effect of cardiac function

Chinese medicine (CM) syndromes

scores of symptoms

signs

and quality of life measured by Minnesota Living with heart failure questionnaire (MLHFQ) before and after the treatment. Totally 112 patients were analyzed in the treatment group and 109 in the control group. They were comparable in NYHA functional class

basic parameters and primary diseases before treatment. Cardiac function and CM syndromes were greatly ameliorated in both groups after treatment. Total effective rates of cardiac function and CM syndrome in the treatment group were significantly higher than those in the control group (P<0.05). Total symptom score and sign score in the treatment group decreased significantly after treatment (P<0.01)

which were significantly lower than those in the control group (P<0.05). There were statistically significant differences in post-treatment scores of gasp

cough with phlegm

pulmonary rales and jugular vein engorgement between the two groups (P<0.05 or P<0.01). Three MLHFQ scores decreased significantly in both groups after treatment (P<0.01). Post-treatment total scale score and physical subscale score in the treatment group and the reduction of them showed statistically significant differences (P<0.05) as compared with the control group. There was no significant difference between the two groups in emotional subscale score and the reduction after treatment (P>0.05). There was no obvious adverse reaction in either group noted during the study. Yangxinkang Tablets were safe and efficacious in improving cardiac function

CM syndromes

symptoms

signs

and quality of life in patients with CHF class II or III in stage C on the base of conventional treatment.

Abstract

To investigate the safety and efficacy of Yangxinkang Tablets (养心康片) in patients with chronic heart failure (CHF) and syndrome of qi and yin deficiency

blood stasis

and water retention. In a double-blinded

randomized

placebo-controlled

multicenter clinical trail

Chinese medicine (CM) syndromes

scores of symptoms

signs

which were significantly lower than those in the control group (P<0.05). There were statistically significant differences in post-treatment scores of gasp

cough with phlegm

CM syndromes

symptoms

signs

and quality of life in patients with CHF class II or III in stage C on the base of conventional treatment.

关键词

chronic heart failureChinese Medicinecardiac functionsyndromequality of life

Keywords

chronic heart failureChinese Medicinecardiac functionsyndromequality of life

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