Association between genetic variants and characteristic symptoms of type 2 diabetes: A matched case-control study

Hao-ying Dou; Yuan-yuan Wang; Nan Yang; Ming-li Heng; Xuan Zhou; Huai-en Bu; Fang Xu; Tie-niu Zhao; He Huang; Hong-wu Wang

doi:10.1007/s11655-015-2290-3

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Association between genetic variants and characteristic symptoms of type 2 diabetes: A matched case-control study

OriginalPaper | Updated：2021-08-27

- Association between genetic variants and characteristic symptoms of type 2 diabetes: A matched case-control study
- Association between genetic variants and characteristic symptoms of type 2 diabetes: A matched case-control study
- 中国结合医学杂志（英文版） 2017年23卷第6期页码：415-424
- Affiliations：
  
  1. Department of Nursing, Tianjin University of Traditional Chinese Medicine,Tianjin,China
  2. Department of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine,Tianjin,China
  3. Department of Biochemical Engineering, School of Chemical Engineering and Technology, Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin University,Tianjin,China
- Author bio：
- Funds：
  
  Supported by the Project of Science and Technology Development of Tianjin Municipality, China (No. 033113211), the Key Cultivated Academic Construction Project of State Administrative Bureau for Prophylactic Medicine of Traditional Chinese Medicine, China (No. 2012)
- DOI：10.1007/s11655-015-2290-3
  中图分类号：
- 纸质出版日期：2017，
  
  网络出版日期：2016-2-26，
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Dou, Hy., Wang, Yy., Yang, N. et al. Association between genetic variants and characteristic symptoms of type 2 diabetes: A matched case-control study., Chin. J. Integr. Med. 23, 415–424 (2017). https://doi.org/10.1007/s11655-015-2290-3

Hao-ying Dou, Yuan-yuan Wang, Nan Yang, et al. Association between genetic variants and characteristic symptoms of type 2 diabetes: A matched case-control study[J]. Chinese Journal of Integrative Medicine, 2017,23(6):415-424.
Dou, Hy., Wang, Yy., Yang, N. et al. Association between genetic variants and characteristic symptoms of type 2 diabetes: A matched case-control study., Chin. J. Integr. Med. 23, 415–424 (2017). https://doi.org/10.1007/s11655-015-2290-3 DOI：

Hao-ying Dou, Yuan-yuan Wang, Nan Yang, et al. Association between genetic variants and characteristic symptoms of type 2 diabetes: A matched case-control study[J]. Chinese Journal of Integrative Medicine, 2017,23(6):415-424. DOI： 10.1007/s11655-015-2290-3.

摘要

To examine the association of genetic variants with characteristic symptoms of type 2 diabetes mellitus (T2DM). A matched case-control study was performed to investigate the association between common variants in four genes (CDKAL1

GLIS3

GRK5

and TCF7L2) and symptoms of T2DM. Symptoms were examined with questionnaire for 710 subjects. Genomic DNA was extracted from peripheral blood mononuclear cell by salting-out procedure. Genotyping was carried out by direct sequencing of the unpurified polymerase chain reaction products. Most of the T2DM patients pressented characteristic symptoms

such as feeling weak in limbs (P =0.0057)

hand tremor (P =0.0208)

bradymasesis (P =0.0234)

and polyuria (P =0.0051). Some of the T2DM patients shared characteristic symptoms

such as desire for cold drinks (P =0.0304)

polyphagia (P =0.0051)

and furred tongue (P =0.028). The impaired glucose regulation (IGR) cases took only one characteristic symptom of frequent micturition (P =0.0422). GLIS3 rs7034200 and GRK5 rs10886471 were significantly associated with increased T2DM risk (GLIS3 rs7034200 under dominant model: P=0.0307; GRK5 rs10886471 under recessive model: P=0.0092). However

only the rs10886471 polymorphism in GRK5 showed a significant effect on both differentiated symptoms and T2DM risk. The C-allele was involved in both dampness-heat encumbering Pi (Spleen) syndrome (P =0.047) and qi-yin deficiency syndrome (P =0.002) via increased GRK5 expression. Both T2DM and IGR exhibited its corresponding characteristic symptoms. The variants of GRK5 were involved with both qi-yin deficiency syndrome and dampness-heat encumbering Pi syndrome.

Abstract

GLIS3

GRK5

such as feeling weak in limbs (P =0.0057)

hand tremor (P =0.0208)

bradymasesis (P =0.0234)

and polyuria (P =0.0051). Some of the T2DM patients shared characteristic symptoms

such as desire for cold drinks (P =0.0304)

polyphagia (P =0.0051)

关键词

type 2 diabetes mellitusimpaired glucose regulationChinese Medicinesyndromesgenetic variants

Keywords

type 2 diabetes mellitusimpaired glucose regulationChinese Medicinesyndromesgenetic variants

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