Protective effects of Xiongshao Capsule (芎芍胶囊) on anti-inflammatory function of high-density lipoprotein in an atherosclerosis rabbit model

Yan-hong Zhang; Ying Zhang; Jing Li; Wen-xin Tong; Feng-qin Xu

doi:10.1007/s11655-015-2298-8

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Protective effects of Xiongshao Capsule (芎芍胶囊) on anti-inflammatory function of high-density lipoprotein in an atherosclerosis rabbit model

OriginalPaper | Updated：2021-08-27

- Protective effects of Xiongshao Capsule (芎芍胶囊) on anti-inflammatory function of high-density lipoprotein in an atherosclerosis rabbit model
- Protective effects of Xiongshao Capsule (芎芍胶囊) on anti-inflammatory function of high-density lipoprotein in an atherosclerosis rabbit model
- 中国结合医学杂志（英文版） 2017年23卷第5期页码：357-361
- Affiliations：
  
  1. Department of Emergency, Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing,China
  2. Department of General Medicine, Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing,China
  3. Administration Office, Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 81173385)
- DOI：10.1007/s11655-015-2298-8
  中图分类号：
- 纸质出版日期：2017，
  
  网络出版日期：2015-10-10，
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Zhang, Yh., Zhang, Y., Li, J. et al. Protective effects of Xiongshao Capsule (芎芍胶囊) on anti-inflammatory function of high-density lipoprotein in an atherosclerosis rabbit model., Chin. J. Integr. Med. 23, 357–361 (2017). https://doi.org/10.1007/s11655-015-2298-8

Yan-hong Zhang, Ying Zhang, Jing Li, et al. Protective effects of Xiongshao Capsule (芎芍胶囊) on anti-inflammatory function of high-density lipoprotein in an atherosclerosis rabbit model[J]. Chinese Journal of Integrative Medicine, 2017,23(5):357-361.
Zhang, Yh., Zhang, Y., Li, J. et al. Protective effects of Xiongshao Capsule (芎芍胶囊) on anti-inflammatory function of high-density lipoprotein in an atherosclerosis rabbit model., Chin. J. Integr. Med. 23, 357–361 (2017). https://doi.org/10.1007/s11655-015-2298-8 DOI：

Yan-hong Zhang, Ying Zhang, Jing Li, et al. Protective effects of Xiongshao Capsule (芎芍胶囊) on anti-inflammatory function of high-density lipoprotein in an atherosclerosis rabbit model[J]. Chinese Journal of Integrative Medicine, 2017,23(5):357-361. DOI： 10.1007/s11655-015-2298-8.

摘要

To observe the effects of Xiongshao Capsule (芎芍胶囊

XSC) on anti-inflflammatory properties of high-density lipoprotein (HDL)

myeloperoxidase (MPO) and paraoxonase 1 (PON1) in serum of atherosclerosis (AS) rabbit model and explore the anti-inflflammatory protective effects of XSC on HDL. Sixty rabbits were randomized into the control

the model

XSC low-

medium- and high-dose (Rhizoma Chuanxiong + Radix Paeoniae rubra: 0.6+0.3

1.2+0.6

2.4+1.2g·kg-1·day-1

respectively)

and simvastatin (1g·kg-1·day-1) groups. The model rabbits were fed with high-fat diet and drugs for 15 weeks. The blood and thoracic aortas samples were collected at the end of 15 weeks. The levels of serum MPO and PON1 as well as total cholesterol (TC) and free cholesterol (FC) in aorta wall cells were tested by enzyme linked immunosorbent assay. TC and FC in the model group were significantly higher than those in the control group (P<0.01). Compared with the model group

TC and FC in the XSC groups were signifificantly lower (P<0.05 or P<0.01)

so was simvastatin group (P<0.01). There was no signifificant difference in PON1 level between groups (P>0.05)

even between model and control groups (P>0.05). The serum MPO level in the model group was signifificantly higher than that in the control group (P<0.05)

which was signifificantly lower in XSC groups as well as simvastatin group (P<0.05 or P<0.01)

and no difference was found between XSC groups and simvastatin group (P>0.05). XSC can reduce the serum MPO level in AS rabbits to protect the anti-inflammatory function of HDL

maintaining the normal lipid transport function. TC and FC levels in aorta cells decline

and this process initiated by XSC plays an anti-AS role.

Abstract

To observe the effects of Xiongshao Capsule (芎芍胶囊

XSC) on anti-inflflammatory properties of high-density lipoprotein (HDL)

the model

XSC low-

medium- and high-dose (Rhizoma Chuanxiong + Radix Paeoniae rubra: 0.6+0.3

1.2+0.6

2.4+1.2g·kg-1·day-1

respectively)

TC and FC in the XSC groups were signifificantly lower (P<0.05 or P<0.01)

so was simvastatin group (P<0.01). There was no signifificant difference in PON1 level between groups (P>0.05)

even between model and control groups (P>0.05). The serum MPO level in the model group was signifificantly higher than that in the control group (P<0.05)

which was signifificantly lower in XSC groups as well as simvastatin group (P<0.05 or P<0.01)

and no difference was found between XSC groups and simvastatin group (P>0.05). XSC can reduce the serum MPO level in AS rabbits to protect the anti-inflammatory function of HDL

maintaining the normal lipid transport function. TC and FC levels in aorta cells decline

and this process initiated by XSC plays an anti-AS role.

关键词

blood-activating and stasis-dissolvinganti-atherosclerosisanti-inflammatoryfunctional high density lipoproteinChinese Medicine

Keywords

blood-activating and stasis-dissolvinganti-atherosclerosisanti-inflammatoryfunctional high density lipoproteinChinese Medicine

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