Peri-articular lymphatic system and "Bi" theory of Chinese medicine in the pathogenesis and treatment of arthritis

Qian-qian Liang; Qi Shi; Ronald W. Wood; Lian-ping Xing; Yong-jun Wang

doi:10.1007/s11655-015-2305-0

Your Location：

Home >

Browse articles >

Peri-articular lymphatic system and "Bi" theory of Chinese medicine in the pathogenesis and treatment of arthritis

OriginalPaper | Updated：2021-08-27

- Peri-articular lymphatic system and "Bi" theory of Chinese medicine in the pathogenesis and treatment of arthritis
- Peri-articular lymphatic system and "Bi" theory of Chinese medicine in the pathogenesis and treatment of arthritis
- 中国结合医学杂志（英文版） 2015年21卷第9期页码：648-655
- Affiliations：
  
  1. Department of Orthopaedics, Longhua Hospital, Shanghai University of Traditional Chinese Medicine,Shanghai,China
  2. Department of Obstetrics and Gynecology, Urology, and Neurobiology and Anatomy, University of Rochester Medical Center,Rochester,USA
  3. Department of Pathology and Laboratory Medicine, University of Rochester Medical Center,Rochester,USA
  4. Center for Musculoskeletal Research, University of Rochester Medical Center,Rochester,USA
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation, China (No. 81403417, No. 81330085 and No. 81220108027);Special Funding for the National Outstanding Doctoral Dissertation, China (No. 201276);National Institutes of Health, USA (No. AR048697 and No. AR063650);the Lymphatic Malformation Institute, USA;Ministry of Education, Innovative Research Team, China (No. IRT1270);and Shanghai University of Traditional Chinese Medicine, China (085 Project, No. 085ZY1204)
- DOI：10.1007/s11655-015-2305-0
  中图分类号：
- 纸质出版日期：2015，
  
  网络出版日期：2015-10-3，
Scan for full text
Liang, Qq., Shi, Q., Wood, R.W. et al. Peri-articular lymphatic system and "Bi" theory of Chinese medicine in the pathogenesis and treatment of arthritis., Chin. J. Integr. Med. 21, 648–655 (2015). https://doi.org/10.1007/s11655-015-2305-0

Qian-qian Liang, Qi Shi, Ronald W. Wood, et al. Peri-articular lymphatic system and "Bi" theory of Chinese medicine in the pathogenesis and treatment of arthritis[J]. Chinese Journal of Integrative Medicine, 2015,21(9):648-655.
Liang, Qq., Shi, Q., Wood, R.W. et al. Peri-articular lymphatic system and "Bi" theory of Chinese medicine in the pathogenesis and treatment of arthritis., Chin. J. Integr. Med. 21, 648–655 (2015). https://doi.org/10.1007/s11655-015-2305-0 DOI：

Qian-qian Liang, Qi Shi, Ronald W. Wood, et al. Peri-articular lymphatic system and "Bi" theory of Chinese medicine in the pathogenesis and treatment of arthritis[J]. Chinese Journal of Integrative Medicine, 2015,21(9):648-655. DOI： 10.1007/s11655-015-2305-0.

摘要

Rheumatoid arthritis (RA) and osteoarthritis (OA) are the two most common joint diseases

and they have characterization of synovial inflammation and cartilage destruction

associated with the accumulation of numerous catabolic mediators and inflammatory cells in the synovial space and surrounding soft tissues. How these factors are cleared and if the "clearance" process contributes to pathogenesis of arthritis are not known. Recently

we found the existence of the peri-articular lymphatic system in mouse joints. The blockade of lymphangiogenesis and lymphatic draining function accelerates while stimulation of lymphatic function attenuates the severity of joint tissue lesions in mouse models of RA and OA. More importantly

we noticed the similarity between the dysfunction of lymphatic drainage in arthritic joints and "Bi" theory of Chinese medicine (CM)

and demonstrated that several Bi disease-treated herbal drugs directly affect the function of lymphatic endothelial cells. Here we review the advances about the interactions between joint inflammation and changes in the peri-articular lymphatic system and discuss our view of linking "Bi" theory of CM to lymphatic dysfunction in arthritis.

Abstract

Rheumatoid arthritis (RA) and osteoarthritis (OA) are the two most common joint diseases

and they have characterization of synovial inflammation and cartilage destruction

we noticed the similarity between the dysfunction of lymphatic drainage in arthritic joints and "Bi" theory of Chinese medicine (CM)

关键词

rheumatoid arthritisosteoarthritislymphatic systemBi diseaseChinese Medicine

Keywords

rheumatoid arthritisosteoarthritislymphatic systemBi diseaseChinese Medicine

references

Bergman MJ. Social and economic impact of inflammatory arthritis. Postgrad Med 2006;Spec No:5–11.

Churov AV, Oleinik EK, Knip M. MicroRNAs in rheumatoid arthritis: altered expression and diagnostic potential. Autoimmun Rev 2015 Jul 8 [Epub ahead of print].

Kasapcopur O, Barut K. Treatment in juvenile rheumatoid arthritis and new treatment options. Turk Pediatr Ars 2015;50:1–10.

Remst DF, Blaney Davidson EN, van der Kraan PM. Unravelling osteoarthritis-related synovial fibrosis: a step closer to solving joint stiffness. Rheumatology (Oxford) 2015 Jul 13 [Epub ahead of print].

Ham O, Lee CY, Kim R, Lee J, Oh S, Lee MY, et al. Therapeutic potential of differentiated mesenchymal stem cells for treatment of osteoarthritis. Int J Mol Sci 2015;16:14961–14978.

Kandahari AM, Yang X, Dighe AS, Pan D, Cui Q. Recognition of immune response for the early diagnosis and treatment of osteoarthritis. J Immunol Res 2015;2015:192415.

Moots RJ, Mays R, Stephens J, Tarallo M. Burden of dose escalation with tumour necrosis factor inhibitors in rheumatoid arthritis: a systematic review of frequency and costs. Clin Exp Rheumatol 2015 Jun 8 [Epub ahead of print].

Wang G, Mu R, Xu H. Management of rheumatoid arthritis in People's Republic of China—focus on tocilizumab and patient considerations. Int J Gen Med 2015;8:187–194.

Shi JX, Liang QQ, Wang YJ, Mooney RA, Boyce BF, Xing L. Use of a whole-slide imaging system to assess the presence and alteration of lymphatic vessels in joint sections of arthritic mice. Biotech Histochem 2012;88:428–439.

Zhou Q, Wood R, Schwarz EM, Wang YJ, Xing L. Near-infrared lymphatic imaging demonstrates the dynamics of lymph flow and lymphangiogenesis during the acute versus chronic phases of arthritis in mice. Arthritis Rheum 2010;62:1881–1889.

Guo R, Zhou Q, Proulx ST, Wood R, Ji RC, Ritchlin CT, et al. Inhibition of lymphangiogenesis and lymphatic drainage via vascular endothelial growth factor receptor 3 blockade increases the severity of inflammation in a mouse model of chronic inflammatory arthritis. Arthritis Rheum 2009;60:2666–2676.

Zhou Q, Guo R, Wood R, Boyce BF, Liang Q, Wang YJ, et al. Vascular endothelial growth factor C attenuates joint damage in chronic inflammatory arthritis by accelerating local lymphatic drainage in mice. Arthritis Rheum 2011;63:2318–2328.

van der Flier A, Badu-Nkansah K, Whittaker CA, Crowley D, Bronson RT, Lacy-Hulbert A, et al. Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development. Development 2010;137:2439–2449.

Zhou F, Chang Z, Zhang L, Hong YK, Shen B, Wang B, et al. Akt/protein kinase B is required for lymphatic network formation, remodeling, and valve development. Am J Pathol 2010;177:2124–2133.

Yu M, Zhang H, Liu Y, He Y, Yang C, Du Y, et al. The cooperative role of S1P3 with LYVE-1 in LMW-HA-induced lymphangiogenesis. Exp Cell Res 2015;336:150–157.

McCall AD, Baker OJ. Characterization of angiogenesis and lymphangiogenesis in human minor salivary glands with Sjogren's syndrome. J Histochem Cytochem 2015;63:340–349.

Droitcourt C, Boccara O, Fraitag S, Favrais G, Dupuy A, Maruani A. Multifocal lymphangioendotheliomatosis with thrombocytopenia: clinical features and response to sirolimus. Pediatrics 2015;136:e517–e522.

Tutunea-Fatan E, Majumder M, Xin X, Lala PK. The role of CCL21/CCR7 chemokine axis in breast cancer-induced lymphangiogenesis. Mol Cancer 2015;14:35.

Wada H, Shiozawa M, Katayama K, Okamoto N, Miyagi Y, Rino Y, et al. Systematic review and meta-analysis of histopathological predictive factors for lymph node metastasis in T1 colorectal cancer. J Gastroenterol 2015;50:727–734.

Xu H, Edwards J, Banerji S, Prevo R, Jackson DG, Athanasou NA. Distribution of lymphatic vessels in normal and arthritic human synovial tissues. Ann Rheum Dis 2003;62:1227–1229.

Walsh DA, Verghese P, Cook GJ, McWilliams DF, Mapp PI, Ashraf S, et al. Lymphatic vessels in osteoarthritic human knees. Osteoarthritis Cartilage 2012;20:405–412.

Shi J, Liang Q, Zuscik M, Shen J, Chen D, Xu H, et al. Distribution and alteration of lymphatic vessels in knee joints of normal and osteoarthritic mice. Arthritis Rheumatol 2014;66:657–666.

Liu-Bryan R, Terkeltaub R. Emerging regulators of the inflammatory process in osteoarthritis. Nat Rev Rheumatol 2015;11:35–44.

Wauke K, Nagashima M, Ishiwata T, Asano G, Yoshino S. Expression and localization of vascular endothelial growth factor-C in rheumatoid arthritis synovial tissue. J Rheumatol 2002;29:34–38.

Cha HS, Bae EK, Koh JH, Chai JY, Jeon CH, Ahn KS, et al. Tumor necrosis factor-alpha induces vascular endothelial growth factor-C expression in rheumatoid synoviocytes. J Rheumatol 2007;34:16–19.

Li J, Ju Y, Bouta EM, Xing L, Wood RW, Kuzin I, et al. Efficacy of B cell depletion therapy for murine joint arthritis flare is associated with increased lymphatic flow. Arthritis Rheum 2013;65:130–138.

Li J, Zhou Q, Wood RW, Kuzin I, Bottaro A, Ritchlin CT, et al. CD23(+)/CD21(hi) B-cell translocation and ipsilateral lymph node collapse is associated with asymmetric arthritic fl are in TNF-Tg mice. Arthritis Res Ther 2011;13:R138.

Marques-Rocha JL, Samblas M, Milagro FI, Bressan J, Martínez JA, Marti A. Noncoding RNA, cytokines, and inflammation-related diseases. FASEB J 2015 Jul 11 [Epub ahead of print].

Wojdasiewicz P, Poniatowski LA, Szukiewicz D. The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis. Mediators Inflamm 2014;2014:561459.

Lu LD, Wei S. Progress of traditional Chinese medicine treatment of rheumatoid arthritis. J Liaoning Univ Tradit Chin Med (Chin) 2013;15(10):86–88.

Li J, Yin B. Clinical observation on treating rheumatoid arthritis with the Qubi Decoction. Clin J Chin Med (Chin) 2015;7(11):14–15.

Yang QJ, Guo JC, Yang TP. Research progress of clinical application of Bi syndrome with Duhuo Jisheng Decoction. J Jiangxi Univ Tradit Chin Med (Chin) 2015;27:113–116.

FULL TEXT LINK

More>

浏览量

162

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Effect of Ermiao Recipe (二妙方) with medicinal guide Angelicae Pubescentis Radix on promoting the homing of bone marrow stem cells to treat cartilage damage in osteoarthritis rats

How does Chinese medicine target cytokine imbalance in rheumatoid arthritis?

A one-year evaluation of radiographic progression in patients with rheumatoid arthritis treated by Qingre Huoxue Decoction (清热活血方)

The potential role of Chinese medicine in ameliorating extra-articular manifestations of rheumatoid arthritis

Clinical observation on methotrexate combined with chinese preparations in treating rheumatoid arthritis patients