Bone protection effects of a novel Chinese herbal formula, Taikong Yangxin Prescription (太空养心方), in hindlimb unloaded rats against bone deterioration

Chun-hay Ko; Wing-sum Siu; Chung-Lap Chan; Chi-Man Koon; Kwok-Pui Fung; Yong-Zhi Li; Ying-hui Li; Ping-chung Leung

doi:10.1007/s11655-015-2310-3

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Bone protection effects of a novel Chinese herbal formula, Taikong Yangxin Prescription (太空养心方), in hindlimb unloaded rats against bone deterioration

OriginalPaper | Updated：2021-08-27

- Bone protection effects of a novel Chinese herbal formula, Taikong Yangxin Prescription (太空养心方), in hindlimb unloaded rats against bone deterioration
- Bone protection effects of a novel Chinese herbal formula, Taikong Yangxin Prescription (太空养心方), in hindlimb unloaded rats against bone deterioration
- 中国结合医学杂志（英文版） 2015年21卷第10期页码：759-764
- Affiliations：
  
  1. Institute of Chinese Medicine, Chinese University of Hong Kong,Hong Kong,China
  2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Chinese University of Hong Kong,Hong Kong,China
  3. State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut research and Training Center,Beijing,China
- Author bio：
- Funds：
  
  Supported by Focused Investments Scheme: One-off Support (Scheme D)–Collaboration with the China Astronaut Research and Training Centre (No. RAC/2006/182), the Chinese University of Hong Kong, Hong Kong SAR, China
- DOI：10.1007/s11655-015-2310-3
  中图分类号：
- 纸质出版日期：2015，
  
  网络出版日期：2015-11-3，
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Ko, CH., Siu, WS., Chan, CL. et al. Bone protection effects of a novel Chinese herbal formula, Taikong Yangxin Prescription (太空养心方), in hindlimb unloaded rats against bone deterioration., Chin. J. Integr. Med. 21, 759–764 (2015). https://doi.org/10.1007/s11655-015-2310-3

Chun-hay Ko, Wing-sum Siu, Chung-Lap Chan, et al. Bone protection effects of a novel Chinese herbal formula, Taikong Yangxin Prescription (太空养心方), in hindlimb unloaded rats against bone deterioration[J]. Chinese Journal of Integrative Medicine, 2015,21(10):759-764.
Ko, CH., Siu, WS., Chan, CL. et al. Bone protection effects of a novel Chinese herbal formula, Taikong Yangxin Prescription (太空养心方), in hindlimb unloaded rats against bone deterioration., Chin. J. Integr. Med. 21, 759–764 (2015). https://doi.org/10.1007/s11655-015-2310-3 DOI：

Chun-hay Ko, Wing-sum Siu, Chung-Lap Chan, et al. Bone protection effects of a novel Chinese herbal formula, Taikong Yangxin Prescription (太空养心方), in hindlimb unloaded rats against bone deterioration[J]. Chinese Journal of Integrative Medicine, 2015,21(10):759-764. DOI： 10.1007/s11655-015-2310-3.

摘要

To investigate the protective effects of a Chinese herbal formula

Taikong Yangxin Prescription (太空养心方

TKYXP) against bone deterioration in a hindlimb unloaded (tail-suspension) rat model. Thirty-two male Sprague-Dawley rats were divided into 4 groups: tail-suspension group fed with 2.5 g•kg-1•day-1 of TKYXP extract (high dose)

tail-suspension group fed with 1.25 g•kg-1•day-1 (low dose)

tail-suspended group treated with water placebo (placebo control group) and non tail-suspended group. The effects of TKYXP on bone were assessed using peripheral quantitative computed tomography (pQCT)

microcomputerized tomography (micro-CT) and three-point bending biomechanical test on the femur in vivo. TKYXP had a significant protective effect against bone loss induced by tail-suspension on day 28

as shown in the reduction in bone mineral density (BMD) loss

preservation of bone micro-architecture and biomechanical strength. The administration ofhigh dose TKYXP could significantly reduce the total BMD loss by 4.8% and 8.0% at the femur and tibia regions

respectively

compared with the placebo control group (P<0.01) on day 28. Its bone protective effect on the femur was further substantiated by the increases of the trabecular BMD (by 6.6%)

bone volume fraction (by 20.9%)

trabecular number (by 9.5%) and thickness (by 11.9%) as compared with the placebo control group. TKYXP may protect the bone under weightless inflfl uence from gradual structural deterioration in the tail-suspension model.

Abstract

To investigate the protective effects of a Chinese herbal formula

Taikong Yangxin Prescription (太空养心方

tail-suspension group fed with 1.25 g•kg-1•day-1 (low dose)

as shown in the reduction in bone mineral density (BMD) loss

preservation of bone micro-architecture and biomechanical strength. The administration ofhigh dose TKYXP could significantly reduce the total BMD loss by 4.8% and 8.0% at the femur and tibia regions

respectively

compared with the placebo control group (P<0.01) on day 28. Its bone protective effect on the femur was further substantiated by the increases of the trabecular BMD (by 6.6%)

bone volume fraction (by 20.9%)

关键词

tail-suspension rat modelosteoporosis peripheral quantitative computed tomographymicro-computerized tomographyChinese Herbal Medicine

Keywords

tail-suspension rat modelosteoporosis peripheral quantitative computed tomographymicro-computerized tomographyChinese Herbal Medicine

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