A systematic review of anticancer effects of Radix Astragali

Yeehong Jung; Uimin Jerng; Sookyung Lee

doi:10.1007/s11655-015-2324-x

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A systematic review of anticancer effects of Radix Astragali

OriginalPaper | Updated：2021-08-27

- A systematic review of anticancer effects of Radix Astragali
- A systematic review of anticancer effects of Radix Astragali
- 中国结合医学杂志（英文版） 2016年22卷第3期页码：225-236
- Affiliations：
  
  1. Department of Clinical Oncology, College of Korean Medicine, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea
  2. Clinical Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea
- Author bio：
- Funds：
- DOI：10.1007/s11655-015-2324-x
  中图分类号：
- 纸质出版日期：2016，
  
  网络出版日期：2015-12-7，
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Jung, Y., Jerng, U. & Lee, S. A systematic review of anticancer effects of Radix Astragali, ., Chin. J. Integr. Med. 22, 225–236 (2016). https://doi.org/10.1007/s11655-015-2324-x

Yeehong Jung, Uimin Jerng, Sookyung Lee. A systematic review of anticancer effects of Radix Astragali[J]. Chinese Journal of Integrative Medicine, 2016,22(3):225-236.
Jung, Y., Jerng, U. & Lee, S. A systematic review of anticancer effects of Radix Astragali, ., Chin. J. Integr. Med. 22, 225–236 (2016). https://doi.org/10.1007/s11655-015-2324-x DOI：

Yeehong Jung, Uimin Jerng, Sookyung Lee. A systematic review of anticancer effects of Radix Astragali[J]. Chinese Journal of Integrative Medicine, 2016,22(3):225-236. DOI： 10.1007/s11655-015-2324-x.

摘要

To review the anticancer effects of Radix astragali (RA)

one of the most commonly used herbs to manage cancer in East Asia

and its constituents and to provide evidence of clinical usage through previously performed clinical studies. Preclinical and clinical studies related to the anticancer effects of RA were searched from inception to November 2013 in electronic databases. Two reviewers independently investigated 92 eligible studies

extracted all the data of studies and appraised methodological quality of clinical trials. The studies were categorized into in vitro and in vivo experimental studies and clinical studies

and analyzed by saponins

polysaccharides

and flavonoids of RA constituents

RA fraction

and whole extract. In preclinical studies

RA was reported to have tumor growth inhibitory effects

immunomodulatory effects

and attenuating adverse effects by cytotoxic agents as well as chemopreventive effects. Saponins seemed to be the main constituents

which directly contributed to suppression of tumor growth through the activation of both intrinsic and extrinsic apoptotic pathway

modulation of intracellular signaling pathway

and inhibition of invasion and angiogenesis. Flavonoids suppressed tumor growth through the similar mechanisms with saponins. Polysaccharides showed immunomodulatory effects

contributing tumor shrinkages in animal models

despite the low cytotoxicity to cancer cells. Most of the clinical studies were performed with low evidence level of study designs because of various limitations. RA whole extracts and polysaccharides of RA were reported to improve the quality of life and ameliorate myelosuppression and other adverse events induced by cytotoxic therapies. The polysaccharides

saponins

and flavonoids of RA

and the whole extract of RA have been widely reported with their anticancer effects in preclinical studies and showed a potential application as a adjunctive cancer therapeutics with the activities of immunomodulation

anti-proliferation and attenuation of adverse effects induced by cytotoxic therapy.

Abstract

To review the anticancer effects of Radix astragali (RA)

one of the most commonly used herbs to manage cancer in East Asia

extracted all the data of studies and appraised methodological quality of clinical trials. The studies were categorized into in vitro and in vivo experimental studies and clinical studies

and analyzed by saponins

polysaccharides

and flavonoids of RA constituents

RA fraction

and whole extract. In preclinical studies

RA was reported to have tumor growth inhibitory effects

immunomodulatory effects

and attenuating adverse effects by cytotoxic agents as well as chemopreventive effects. Saponins seemed to be the main constituents

which directly contributed to suppression of tumor growth through the activation of both intrinsic and extrinsic apoptotic pathway

modulation of intracellular signaling pathway

and inhibition of invasion and angiogenesis. Flavonoids suppressed tumor growth through the similar mechanisms with saponins. Polysaccharides showed immunomodulatory effects

contributing tumor shrinkages in animal models

saponins

and flavonoids of RA

anti-proliferation and attenuation of adverse effects induced by cytotoxic therapy.

关键词

Radix Astragalianticancer agentscancersystematic review

Keywords

Radix Astragalianticancer agentscancersystematic review

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