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Pleiotropic effects of herbs characterized with blood-activating and stasis-resolving functions on angiogenesis
Pleiotropic effects of herbs characterized with blood-activating and stasis-resolving functions on angiogenesis
- 中国结合医学杂志（英文版） 2016年22卷第10期 页码：795-800
- Affiliations：
1. Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine,Nanjing,China
2. Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine,Nanjing,China
3. Department of Pharmacy, Provincial Hospital Affiliated to Anhui Medical University,Hefei,China
4. Fujian Provincial Hospital, Clinical College of Fujian Medical University,Fuzhou,China
5. Department of Pharmacology, Hanlin College, Nanjing University of Chinese Medicine,Jiangsu Province,Taizhou,China
6. Department of Pharmaceutics, Jinling Hospital, Nanjing University School of Medicine,Nanjing,China
- Author bio：
- Funds：Supported by the National Natural Science Foundation of China (Nos. 81173174, 81403260 and 81573859), China Post-doctoral Science Foundation (No. 2014M551639), Natural Science Foundation of Jiangsu Province (No. BK2012854), Postdoctoral Funding in Jiangsu Province (No. 1401138C), 2013 Program for Excellent Scientific and Technological Innovation Team of Jiangsu Higher Education (No. PPZY2015A070), the Priority Academic Program Development of Jiangsu Higher Education Institutions, and Jiangsu College Graduate Research and Innovation Projects (No. CXZZ13_0627)
DOI：10.1007/s11655-015-2405-x
中图分类号：纸质出版日期：2016，
网络出版日期：2016-6-29，
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Tao, L., Wang, S., Zhao, Y. et al. Pleiotropic effects of herbs characterized with blood-activating and stasis-resolving functions on angiogenesis., Chin. J. Integr. Med. 22, 795–800 (2016). https://doi.org/10.1007/s11655-015-2405-x
Li Tao, Sheng Wang, Yang Zhao, et al. Pleiotropic effects of herbs characterized with blood-activating and stasis-resolving functions on angiogenesis[J]. Chinese Journal of Integrative Medicine, 2016,22(10):795-800.
Tao, L., Wang, S., Zhao, Y. et al. Pleiotropic effects of herbs characterized with blood-activating and stasis-resolving functions on angiogenesis., Chin. J. Integr. Med. 22, 795–800 (2016). https://doi.org/10.1007/s11655-015-2405-x DOI：
Li Tao, Sheng Wang, Yang Zhao, et al. Pleiotropic effects of herbs characterized with blood-activating and stasis-resolving functions on angiogenesis[J]. Chinese Journal of Integrative Medicine, 2016,22(10):795-800. DOI： 10.1007/s11655-015-2405-x.
摘要
Accumulative evidences have underpinned the nature candidates from Chinese medicine (CM)
particularly CM served as blood activating and stasis resolving (BASR
Huoxue Huayu in Chinese) by targeting tumor-associated angiogenesis. However
recent experiment research on the therapeutic angiogenesis by BASR-CM attracts wide attention and discussion. This opinion review focused on the underlying link between two indications and anticipated that (1) BASR-CM might emphasize on a balanced multi-cytokines network interaction; (2) BASR-CM might address on the nature of diseases prior to differently affecting physiological and pathological angiogenesis; (3) BASR-CM might mainly act on perivascular cells
either promotes arteriogenesis by increasing arteriogenic factors in ischemic diseases
or simultaneously keep a quiescent vasculature to impede angiogenesis in tumor context.
Abstract
Accumulative evidences have underpinned the nature candidates from Chinese medicine (CM)
particularly CM served as blood activating and stasis resolving (BASR
Huoxue Huayu in Chinese) by targeting tumor-associated angiogenesis. However
recent experiment research on the therapeutic angiogenesis by BASR-CM attracts wide attention and discussion. This opinion review focused on the underlying link between two indications and anticipated that (1) BASR-CM might emphasize on a balanced multi-cytokines network interaction; (2) BASR-CM might address on the nature of diseases prior to differently affecting physiological and pathological angiogenesis; (3) BASR-CM might mainly act on perivascular cells
either promotes arteriogenesis by increasing arteriogenic factors in ischemic diseases
or simultaneously keep a quiescent vasculature to impede angiogenesis in tumor context.
关键词
blood activating and stasis resolvingChinese Medicinepro-angiogenesisanti-angiogenesisphysiological angiogenesispathological angiogenesisarteriogenesis
Keywords
blood activating and stasis resolvingChinese Medicinepro-angiogenesisanti-angiogenesisphysiological angiogenesispathological angiogenesisarteriogenesis
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