Inhibitory effect of the extract of Phellodendron amurense ruprecht root on collagen-induced arthritis in mice

Hyo Won Jung; Kyung-Ho Kim; Yong-Ki Park

doi:10.1007/s11655-016-2094-5

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Inhibitory effect of the extract of Phellodendron amurense ruprecht root on collagen-induced arthritis in mice

OriginalPaper | Updated：2021-08-27

- Inhibitory effect of the extract of Phellodendron amurense ruprecht root on collagen-induced arthritis in mice
- Inhibitory effect of the extract of Phellodendron amurense ruprecht root on collagen-induced arthritis in mice
- 中国结合医学杂志（英文版） 2017年23卷第10期页码：755-762
- Affiliations：
  
  1. Department of Herbology, College of Korean Medicine, Dongguk University, Gyeongju, Republic of Korea
  2. Korean Medicine Research and Development Center, Dongguk University, Gyeongju, Republic of Korea
  3. Department of Acupuncture, College of Korean Medicine, Dongguk University, Gyeongju, Republic of Korea
- Author bio：
- Funds：
- DOI：10.1007/s11655-016-2094-5
  中图分类号：
- 纸质出版日期：2017，
  
  网络出版日期：2016-7-26，
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Jung, H.W., Kim, KH. & Park, YK. Inhibitory effect of the extract of Phellodendron amurense ruprecht root on collagen-induced arthritis in mice., Chin. J. Integr. Med. 23, 755–762 (2017). https://doi.org/10.1007/s11655-016-2094-5

Hyo Won Jung, Kyung-Ho Kim, Yong-Ki Park. Inhibitory effect of the extract of Phellodendron amurense ruprecht root on collagen-induced arthritis in mice[J]. Chinese Journal of Integrative Medicine, 2017,23(10):755-762.
Jung, H.W., Kim, KH. & Park, YK. Inhibitory effect of the extract of Phellodendron amurense ruprecht root on collagen-induced arthritis in mice., Chin. J. Integr. Med. 23, 755–762 (2017). https://doi.org/10.1007/s11655-016-2094-5 DOI：

Hyo Won Jung, Kyung-Ho Kim, Yong-Ki Park. Inhibitory effect of the extract of Phellodendron amurense ruprecht root on collagen-induced arthritis in mice[J]. Chinese Journal of Integrative Medicine, 2017,23(10):755-762. DOI： 10.1007/s11655-016-2094-5.

摘要

To investigate whether the dried root of Phellodendron amurense Ruprecht (Phellodendri cortex; PC) extract improves arthritic symptoms through anti-inflammatory and immune-modulatory effects in collagen-induced arthritis in mice. Rheumatoid arthritis (RA) was induced in male DBA/1 mice by immunization with type II collagen (ColII). CIA mice were divided into 5 groups (n=10 per a group) with normal

CIA control

PC extract (50 mg/kg and 100 mg/kg)-treated

and meloxicam (50 mg/kg)-treated as the reference drug. The PC extract or meloxicam were administered orally in CIA mice once a day for 14 days after arthritis induction. Arthritic score

levels of anti-ColII IgG2a antibody

prostaglandin E2 (PGE2)

tumor necrosis factor (TNF)-α

and interleukin (IL)-17 in the sera of CIA mice were measured. Histopathological changes in the ankle joints of CIA mice were also analyzed by staining with hematoxylin and eosin (H and E)

safranin-O and immunohistochemistry using anti-TNF-α and anti-IL-17 antibodies. The arthritic score was increased in CIA mice in a time-dependent manner

as were the serum levels of anti-ColII IgG2a antibody

PGE2

TNF-α

and IL-17. However

the oral administration of PC extract at 50 and 100 mg/kg in CIA mice significantly decreased the arthritic scores

and the serum levels of anti-ColII IgG2a

PGE2

TNF-α

and IL-17 compared with those in the CIA group (P<0.05 or P<0.01). Furthermore

histopathological improvement of the joint architecture in CIA mice was observed after administration of PC extract. PC extract also significantly inhibited the expression of TNF-α and IL-17 in the joints of CIA mice by suppressing the expression of their mRNA and proteins. PC extract may improve the pathological progression of RA through the inhibition of joint destruction by synovial inflammation and immune-stimulation

therefore

it would be a potential anti-arthritic agent in RA.

Abstract

CIA control

PC extract (50 mg/kg and 100 mg/kg)-treated

and meloxicam (50 mg/kg)-treated as the reference drug. The PC extract or meloxicam were administered orally in CIA mice once a day for 14 days after arthritis induction. Arthritic score

levels of anti-ColII IgG2a antibody

prostaglandin E2 (PGE2)

tumor necrosis factor (TNF)-α

and interleukin (IL)-17 in the sera of CIA mice were measured. Histopathological changes in the ankle joints of CIA mice were also analyzed by staining with hematoxylin and eosin (H and E)

safranin-O and immunohistochemistry using anti-TNF-α and anti-IL-17 antibodies. The arthritic score was increased in CIA mice in a time-dependent manner

as were the serum levels of anti-ColII IgG2a antibody

PGE2

TNF-α

and IL-17. However

the oral administration of PC extract at 50 and 100 mg/kg in CIA mice significantly decreased the arthritic scores

and the serum levels of anti-ColII IgG2a

PGE2

TNF-α

and IL-17 compared with those in the CIA group (P<0.05 or P<0.01). Furthermore

therefore

it would be a potential anti-arthritic agent in RA.

关键词

Phellodendron amurensePhellodendri cortexcollagen-induced arthritisanti-arthritic effect

Keywords

Phellodendron amurensePhellodendri cortexcollagen-induced arthritisanti-arthritic effect

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