Key symptoms selection for two major syndromes diagnosis of Chinese medicine in chronic hepatitis B

Yu Zhao; Hong Kang; Jing-hua Peng; Lin Xu; Zhi-wei Cao; Yi-yang Hu

doi:10.1007/s11655-016-2253-3

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Key symptoms selection for two major syndromes diagnosis of Chinese medicine in chronic hepatitis B

OriginalPaper | Updated：2021-08-27

- Key symptoms selection for two major syndromes diagnosis of Chinese medicine in chronic hepatitis B
- Key symptoms selection for two major syndromes diagnosis of Chinese medicine in chronic hepatitis B
- 中国结合医学杂志（英文版） 2017年23卷第4期页码：253-260
- Affiliations：
  
  1. Institute of Liver Disease, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine,Shanghai,China
  2. School of Life Sciences and Technology, Tongji University,Shanghai,China
  3. institute of Shanghai Municipal Education Commission, Shanghai,E,China
- Author bio：
- Funds：
  
  Supported by National Science and Technology Major Project (No. 2012ZX10005001-004, No. 2012ZX09303009-001), National Natural Science Foundation of China (No. 81403298, No. 81373857), Shanghai Natural Science Foundation of China (No. 14ZR1442000), and Shanghai Educational Development Foundation (No. 14CG41)
- DOI：10.1007/s11655-016-2253-3
  中图分类号：
- 纸质出版日期：2017，
  
  网络出版日期：2016-5-25，
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Zhao, Y., Kang, H., Peng, Jh. et al. Key symptoms selection for two major syndromes diagnosis of Chinese medicine in chronic hepatitis B., Chin. J. Integr. Med. 23, 253–260 (2017). https://doi.org/10.1007/s11655-016-2253-3

Yu Zhao, Hong Kang, Jing-hua Peng, et al. Key symptoms selection for two major syndromes diagnosis of Chinese medicine in chronic hepatitis B[J]. Chinese Journal of Integrative Medicine, 2017,23(4):253-260.
Zhao, Y., Kang, H., Peng, Jh. et al. Key symptoms selection for two major syndromes diagnosis of Chinese medicine in chronic hepatitis B., Chin. J. Integr. Med. 23, 253–260 (2017). https://doi.org/10.1007/s11655-016-2253-3 DOI：

Yu Zhao, Hong Kang, Jing-hua Peng, et al. Key symptoms selection for two major syndromes diagnosis of Chinese medicine in chronic hepatitis B[J]. Chinese Journal of Integrative Medicine, 2017,23(4):253-260. DOI： 10.1007/s11655-016-2253-3.

摘要

To identify key symptoms of two major syndromes in chronic hepatitis B (CHB)

which can be the clinical evidence for Chinese medicine (CM) doctors to make decisions. Standardization scales on diagnosis for CHB in CM were designed including physical symptoms

tongue and pulse appearance. The total of 695 CHB cases with dampness-heat (DH) syndrome or Pi (Spleen) deficiency (SD) syndrome were collected for feature selection and modeling

another 275 CHB patients were collected in different locations for validation. Key symptoms were selected based on modified information gain (IG)

and 5 classifiers were applied to assist with models training and validation. Classification accuracy and area under receiver operating characteristic curves (AUC) were evaluated. (1) Thirteen DH syndrome key symptoms and 13 SD syndrome key symptoms were selected from original 125 symptoms; (2) The key symptoms could achieve similar or better diagnostic accuracy than the original total symptoms; (3) In the validation phase

the key symptoms could identify syndromes effectively

especially in DH syndrome

which average prediction accuracy on 5 classifiers could achieve 0.864 with the average AUC 0.772. The selected key symptoms could be simple DH and SD syndromes diagnostic elements applied in clinical directly. (Registration N0.: ChiCTR-DCC-10000759)

Abstract

To identify key symptoms of two major syndromes in chronic hepatitis B (CHB)

which can be the clinical evidence for Chinese medicine (CM) doctors to make decisions. Standardization scales on diagnosis for CHB in CM were designed including physical symptoms

tongue and pulse appearance. The total of 695 CHB cases with dampness-heat (DH) syndrome or Pi (Spleen) deficiency (SD) syndrome were collected for feature selection and modeling

another 275 CHB patients were collected in different locations for validation. Key symptoms were selected based on modified information gain (IG)

the key symptoms could identify syndromes effectively

especially in DH syndrome

关键词

Chinese Medicinesyndromechronic hepatitis Binformation gain

Keywords

Chinese Medicinesyndromechronic hepatitis Binformation gain

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