Lignans-rich extract from Herpetospermum caudigerum alleviate physical fatigue in mice

Shi-ying Jin; Rui-sheng Li; Bao-de Shen; Jin-xia Bai; Ping-hua Xu; Ling Dai; He Xu; Shi-xiao Jin; Jin Han; Hai-long Yuan

doi:10.1007/s11655-016-2254-2

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Lignans-rich extract from Herpetospermum caudigerum alleviate physical fatigue in mice

OriginalPaper | Updated：2021-08-27

- Lignans-rich extract from Herpetospermum caudigerum alleviate physical fatigue in mice
- Lignans-rich extract from Herpetospermum caudigerum alleviate physical fatigue in mice
- 中国结合医学杂志（英文版） 2016年22卷第11期页码：840-845
- Affiliations：
  
  1. Department of Pharmacy, Hospital of People’s Liberation Army,Beijing,China,302
  2. Pharmacy College, Chengdu University of Traditional Chinese Medicine,Chengdu,China
  3. Animal Laboratory Center, Hospital of People’s Liberation Army,Beijing,China,302
  4. Key Lab of Modern Preparation of Traditimal Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine,Nanchang,China
- Author bio：
- Funds：
  
  Supported by the National Key New Drugs Innovation Foundation (No. 2009ZX09103-349) and the Beijing Natural Science Foundation (No. 7122176)
- DOI：10.1007/s11655-016-2254-2
  中图分类号：
- 纸质出版日期：2016，
  
  网络出版日期：2016-10-26，
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Jin, Sy., Li, Rs., Shen, Bd. et al. Lignans-rich extract from Herpetospermum caudigerum alleviate physical fatigue in mice., Chin. J. Integr. Med. 22, 840–845 (2016). https://doi.org/10.1007/s11655-016-2254-2

Shi-ying Jin, Rui-sheng Li, Bao-de Shen, et al. Lignans-rich extract from Herpetospermum caudigerum alleviate physical fatigue in mice[J]. Chinese Journal of Integrative Medicine, 2016,22(11):840-845.
Jin, Sy., Li, Rs., Shen, Bd. et al. Lignans-rich extract from Herpetospermum caudigerum alleviate physical fatigue in mice., Chin. J. Integr. Med. 22, 840–845 (2016). https://doi.org/10.1007/s11655-016-2254-2 DOI：

Shi-ying Jin, Rui-sheng Li, Bao-de Shen, et al. Lignans-rich extract from Herpetospermum caudigerum alleviate physical fatigue in mice[J]. Chinese Journal of Integrative Medicine, 2016,22(11):840-845. DOI： 10.1007/s11655-016-2254-2.

摘要

To ascertain anti-fatigue constituents and mechanisms of Herpetospermum caudigerum. The 80% ethanol extracts of Herpetospermum caudigerum were partitioned with chloroform

ethyl acetate and n-butanol

respectively. Male Kunming mice were divided into 13 groups with 16 mice in each group: a control group fed with water

9 groups treated with 3 fractions of Herpetospermum caudigerum (chloroform fraction

ethyl acetate fraction and n-butanol fraction) at dose of 80

160 and 320 mg/kg for the low-dose group

medium-dose group and high-dose group

3 herpetrione (HPE) treated groups fed with HPE at dose of 15

and 60 mg/kg for the low-dose group

medium-dose group and high-dose group. All animals were treated once per day for 30 days. Anti-fatigue activity was assessed through the forced swimming test and serum biochemical parameters including blood lactic acid (BLA)

blood urea nitrogen (BUN)

malondialdehyde (MDA)

hepatic glycogen (HG)

lactic dehydrogenase (LDH)

superoxide dismutase (SOD) and glutathione peroxidase (GPx) determined following the recommended procedures provided by the commercial kits. Compared with the control group

the lignans extract (ethyl acetate fraction) of Herpetospermum caudigerum and HPE could signifificantly prolonged the exhaustive swimming time (P<0.05 or P<0.01)

and also increased the HG levels (P<0.05 or P<0.01) and the activities of antioxidant enzymes (SOD

GPx and LDH

P<0.05 or P<0.01); BLA and MDA levels were decreased considerably in lignans extract and HPE treated groups (P<0.05 or P<0.01). HPE also could significantly decrease the BUN contents compared with the control group (P<0.05). The chloroform and n-butanol fraction showed no effect on swimming time and biochemical parameters. The lignans extract had antifatigue activities and HPE may be partly responsible for the anti-fatigue effects of Herpetospermum caudigerum. The possible mechanisms of anti-fatigue activity were related to the decrease of BUN and BLA

the increase of the HG storage and protecting corpuscular membrane by preventing lipid oxidation via modifying several enzyme activities.

Abstract

To ascertain anti-fatigue constituents and mechanisms of Herpetospermum caudigerum. The 80% ethanol extracts of Herpetospermum caudigerum were partitioned with chloroform

ethyl acetate and n-butanol

respectively. Male Kunming mice were divided into 13 groups with 16 mice in each group: a control group fed with water

9 groups treated with 3 fractions of Herpetospermum caudigerum (chloroform fraction

ethyl acetate fraction and n-butanol fraction) at dose of 80

160 and 320 mg/kg for the low-dose group

medium-dose group and high-dose group

3 herpetrione (HPE) treated groups fed with HPE at dose of 15

and 60 mg/kg for the low-dose group

blood urea nitrogen (BUN)

malondialdehyde (MDA)

hepatic glycogen (HG)

lactic dehydrogenase (LDH)

superoxide dismutase (SOD) and glutathione peroxidase (GPx) determined following the recommended procedures provided by the commercial kits. Compared with the control group

the lignans extract (ethyl acetate fraction) of Herpetospermum caudigerum and HPE could signifificantly prolonged the exhaustive swimming time (P<0.05 or P<0.01)

and also increased the HG levels (P<0.05 or P<0.01) and the activities of antioxidant enzymes (SOD

GPx and LDH

the increase of the HG storage and protecting corpuscular membrane by preventing lipid oxidation via modifying several enzyme activities.

关键词

Herpetospermum caudigerumlignansherpetrioneanti-fatigue activity

Keywords

Herpetospermum caudigerumlignansherpetrioneanti-fatigue activity

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