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Is Chinese herbal medicine effective for elderly isolated systolic hypertension? A systematic review and meta-analysis
Is Chinese herbal medicine effective for elderly isolated systolic hypertension? A systematic review and meta-analysis
- 中国结合医学杂志（英文版） 2017年23卷第4期 页码：298-305
- Affiliations：
1. Department of Cardiovascular Diseases, Guang’anmen Hospital, China Academy of Chinese Medical Sciences,Beijing,China
2. Gerontology Medical Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing,China
- Author bio：
- Funds：Supported by the National Natural Science Foundation of China (No. 81102721 and No. 81202805), a Planned Technologic Item of State Administration of Traditional Chinese Medicine (No. 04-05LP30), Chinese National Scientic Fund for Post-Doctor (No. 20070410622), its Special Aid Item (No. 201003226) and the Key Technologies R & D Program of Shandong Province, China (No. 2010 GSF 10289)
DOI：10.1007/s11655-016-2257-z
中图分类号：纸质出版日期：2017，
网络出版日期：2016-5-25，
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Cao, Y., Liu, Lt. & Wu, M. Is Chinese herbal medicine effective for elderly isolated systolic hypertension? A systematic review and meta-analysis., Chin. J. Integr. Med. 23, 298–305 (2017). https://doi.org/10.1007/s11655-016-2257-z
Yu Cao, Long-tao Liu, Min Wu. Is Chinese herbal medicine effective for elderly isolated systolic hypertension? A systematic review and meta-analysis[J]. Chinese Journal of Integrative Medicine, 2017,23(4):298-305.
Cao, Y., Liu, Lt. & Wu, M. Is Chinese herbal medicine effective for elderly isolated systolic hypertension? A systematic review and meta-analysis., Chin. J. Integr. Med. 23, 298–305 (2017). https://doi.org/10.1007/s11655-016-2257-z DOI：
Yu Cao, Long-tao Liu, Min Wu. Is Chinese herbal medicine effective for elderly isolated systolic hypertension? A systematic review and meta-analysis[J]. Chinese Journal of Integrative Medicine, 2017,23(4):298-305. DOI： 10.1007/s11655-016-2257-z.
摘要
To study the efficacy of Chinese medicine (CM) on isolated systolic hypertension. Seven electronic databases were searched for randomized controlled trials (RCTs) published until August 2015. Subgroup analyses and meta-analysis were performed to assess the efficacy and safety of the included studies. A total of 24 studies
including 2
096 patients (1
058 patients in the intervention group and 1
038 in the control group)
were evaluated in the final analysis. Compared with a conventional therapy used alone
CM as additional intervention was more effective on systolic blood pressure [mean difference (MD)=–0.66
95% confidence interval (CI)=(–0.97
–0.36)
P<0.00001] and significantly diminished the pulse pressure [MD=–7.49
CI=(–12.69
–2.29)
P<0.00001]. However it showed no additional benefit on diastolic blood pressure [MD=1.16
CI=(0.02
2.29)
P=0.87]. Adverse events were not explicitly reported in most RCTs. CM might be a promising approach for the elderly with isolated systolic hypertension
while the evidence for CM employed alone was insufficient. Considering the inherent limitations of the included studies
larger high-quality RCTs with extensive follow-up should be performed to validate our findings in the future.
Abstract
To study the efficacy of Chinese medicine (CM) on isolated systolic hypertension. Seven electronic databases were searched for randomized controlled trials (RCTs) published until August 2015. Subgroup analyses and meta-analysis were performed to assess the efficacy and safety of the included studies. A total of 24 studies
including 2
096 patients (1
058 patients in the intervention group and 1
038 in the control group)
were evaluated in the final analysis. Compared with a conventional therapy used alone
CM as additional intervention was more effective on systolic blood pressure [mean difference (MD)=–0.66
95% confidence interval (CI)=(–0.97
–0.36)
P<0.00001] and significantly diminished the pulse pressure [MD=–7.49
CI=(–12.69
–2.29)
P<0.00001]. However it showed no additional benefit on diastolic blood pressure [MD=1.16
CI=(0.02
2.29)
P=0.87]. Adverse events were not explicitly reported in most RCTs. CM might be a promising approach for the elderly with isolated systolic hypertension
while the evidence for CM employed alone was insufficient. Considering the inherent limitations of the included studies
larger high-quality RCTs with extensive follow-up should be performed to validate our findings in the future.
关键词
Chinese Herbal Medicineisolated systolic hypertensionmeta-analysissystematic reviewrandomized controlled trial
Keywords
Chinese Herbal Medicineisolated systolic hypertensionmeta-analysissystematic reviewrandomized controlled trial
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