Relationship between Tissue Distributions of Modified Wuzi Yanzong Prescription (加味五子衍宗方) in Rats and Meridian Tropism Theory

Lin-lin Wang; Wei-wei Li; Cai-sheng Wu; Jin-lan Zhang; Yi-xiang Song; Fang-jiao Song; Hong Fu; Geng-xin Liu; Xue-mei Wang

doi:10.1007/s11655-016-2270-2

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Relationship between Tissue Distributions of Modified Wuzi Yanzong Prescription (加味五子衍宗方) in Rats and Meridian Tropism Theory

OriginalPaper | Updated：2021-08-27

- Relationship between Tissue Distributions of Modified Wuzi Yanzong Prescription (加味五子衍宗方) in Rats and Meridian Tropism Theory
- Relationship between Tissue Distributions of Modified Wuzi Yanzong Prescription (加味五子衍宗方) in Rats and Meridian Tropism Theory
- 中国结合医学杂志（英文版） 2018年24卷第2期页码：117-124
- Affiliations：
  
  1. Integrated Laboratory of Traditional Chinese Medicine and Western Medicine, Peking University First Hospital,Beijing,China
  2. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (Nos. 81102683, 30973813 and 81173369), the Doctoral Fund of the Ministry of Education of China (Nos. 20110001120055 and 20120001110105), and the Natural Science Foundation of Beijing City (No. 7132210)
- DOI：10.1007/s11655-016-2270-2
  中图分类号：
- 纸质出版日期：2018，
  
  网络出版日期：2016-12-20，
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Wang, Ll., Li, Ww., Wu, Cs. et al. Relationship between Tissue Distributions of Modified Wuzi Yanzong Prescription (加味五子衍宗方) in Rats and Meridian Tropism Theory., Chin. J. Integr. Med. 24, 117–124 (2018). https://doi.org/10.1007/s11655-016-2270-2

Lin-lin Wang, Wei-wei Li, Cai-sheng Wu, et al. Relationship between Tissue Distributions of Modified Wuzi Yanzong Prescription (加味五子衍宗方) in Rats and Meridian Tropism Theory[J]. Chinese Journal of Integrative Medicine, 2018,24(2):117-124.
Wang, Ll., Li, Ww., Wu, Cs. et al. Relationship between Tissue Distributions of Modified Wuzi Yanzong Prescription (加味五子衍宗方) in Rats and Meridian Tropism Theory., Chin. J. Integr. Med. 24, 117–124 (2018). https://doi.org/10.1007/s11655-016-2270-2 DOI：

Lin-lin Wang, Wei-wei Li, Cai-sheng Wu, et al. Relationship between Tissue Distributions of Modified Wuzi Yanzong Prescription (加味五子衍宗方) in Rats and Meridian Tropism Theory[J]. Chinese Journal of Integrative Medicine, 2018,24(2):117-124. DOI： 10.1007/s11655-016-2270-2.

摘要

To investigate the relationship between tissue distributions of modified Wuzi Yanzong prescription (加味五子衍宗方

MWP) in rats and meridian tropism theory. A high-performance liquid chromatography with Fourier transform-mass spectrometry (HPLC-FT) method was used to identify the metabolites of MWP in different tissues of rats after continued oral administration of MWP for 7 days. The relationship between MWP and meridian tropism theory was studied according to the tissue distributions of the metabolites of MWP in rats and the relevant literature. Nineteen metabolites

mainly flavanoid compounds

were detected in the different rat tissues and classified to each herb in MWP. Further

it was able to establish that the tissue distributions of the metabolites of MWP were consistent with the descriptions of meridian tropism of MWP available in literature

this result might be useful in clarifying the mechanism of MWP on meridian tropism. In the long run

these data might provide scientific evidence of the meridian tropism theory to further promote the reasonable

effective utilization

and modernization of Chinese medicine. The tissue distributions of MWP in vivo were consistent with the descriptions of meridian tropism of MWP.

Abstract

To investigate the relationship between tissue distributions of modified Wuzi Yanzong prescription (加味五子衍宗方

mainly flavanoid compounds

were detected in the different rat tissues and classified to each herb in MWP. Further

it was able to establish that the tissue distributions of the metabolites of MWP were consistent with the descriptions of meridian tropism of MWP available in literature

this result might be useful in clarifying the mechanism of MWP on meridian tropism. In the long run

these data might provide scientific evidence of the meridian tropism theory to further promote the reasonable

effective utilization

and modernization of Chinese medicine. The tissue distributions of MWP in vivo were consistent with the descriptions of meridian tropism of MWP.

关键词

modified Wuzi Yanzong PrescriptionChinese Medicinetissue distributionsmeridian tropismhigh-performance liquid chromatographyFourier transform mass spectrometry

Keywords

modified Wuzi Yanzong PrescriptionChinese Medicinetissue distributionsmeridian tropismhigh-performance liquid chromatographyFourier transform mass spectrometry

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