Effects of Electro-Acupuncture at Zusanli, Guanyuan for Sepsis Patients and Its Mechanism through Immune Regulation

Guang Yang; Rui-ying Hu; Ai-jing Deng; Yu Huang; Jian Li

doi:10.1007/s11655-016-2462-9

Your Location：

Home >

Browse articles >

Effects of Electro-Acupuncture at Zusanli, Guanyuan for Sepsis Patients and Its Mechanism through Immune Regulation

OriginalPaper | Updated：2021-08-27

- Effects of Electro-Acupuncture at Zusanli, Guanyuan for Sepsis Patients and Its Mechanism through Immune Regulation
- Effects of Electro-Acupuncture at Zusanli, Guanyuan for Sepsis Patients and Its Mechanism through Immune Regulation
- 中国结合医学杂志（英文版） 2016年22卷第3期页码：219-224
- Affiliations：
  
  1. Intensive Care Unit, Guangdong Provincal Hospital of Traditional Chinese Medicine,Guangzhou,China
  2. Intensive Care Unit, Wuhan Hospital of Traditional Chinese Medicine,Wuhan,China
- Author bio：
- Funds：
  
  Supported by Project of Chinese Medicine Bureau of Guangdong Province (No. 20121199);Guangdong Provincial Department of Science and Technology Project (No. 2014A020212279)
- DOI：10.1007/s11655-016-2462-9
  中图分类号：
- 纸质出版日期：2016，
  
  网络出版日期：2016-1-29，
Scan for full text
Yang, G., Hu, Ry., Deng, Aj. et al. Effects of Electro-Acupuncture at Zusanli, Guanyuan for Sepsis Patients and Its Mechanism through Immune Regulation., Chin. J. Integr. Med. 22, 219–224 (2016). https://doi.org/10.1007/s11655-016-2462-9

Guang Yang, Rui-ying Hu, Ai-jing Deng, et al. Effects of Electro-Acupuncture at Zusanli, Guanyuan for Sepsis Patients and Its Mechanism through Immune Regulation[J]. Chinese Journal of Integrative Medicine, 2016,22(3):219-224.
Yang, G., Hu, Ry., Deng, Aj. et al. Effects of Electro-Acupuncture at Zusanli, Guanyuan for Sepsis Patients and Its Mechanism through Immune Regulation., Chin. J. Integr. Med. 22, 219–224 (2016). https://doi.org/10.1007/s11655-016-2462-9 DOI：

Guang Yang, Rui-ying Hu, Ai-jing Deng, et al. Effects of Electro-Acupuncture at Zusanli, Guanyuan for Sepsis Patients and Its Mechanism through Immune Regulation[J]. Chinese Journal of Integrative Medicine, 2016,22(3):219-224. DOI： 10.1007/s11655-016-2462-9.

摘要

To evaluate the effect of electro-acupuncture on Zusanli (ST 36)

Guanyuan (RN 4) in patients with sepsis

and explore its mechanism in term of immune regulation. In this prospective randomized controlled trial

60 patients with sepsis were randomly assigned to the control group and the intervention group equally by block randomization. Patients in the control group received routine treatment and those in the intervention group received electro-acupuncture at bilateral Zusanli and Guanyuan in addition to routine treatment

respectively. The mortality at 28 days

Acute Physiology and Chronic Health Evaluation (APACHE)-II score were compared to evaluate the effect

and the levels of T cell subsets (CD3+

CD4+

CD8+

CD4+/CD8+) and monocytes of human leukocyte antigen (HLA)-DR using flow cytometry were compared to explore the mechanism of this combined treatment. Fifty-eight patients completed the trial with 29 in each group. There was no significant difference of mortality in the 28th day between the two groups

with 5 death of 29 patients in the intervention group (17.2%) and 9 of 29 in the control group (31.0%). After treatment

APACHE-II score of both groups was significantly decreased

however

score of the intervention group was lower than the control group (13.28±7.07 vs. 17.10±5.83; P<0.01). The levels of CD3+

CD4+

CD8+ and CD4+/CD8+ ratio of the intervention group improved after treatment and were higher than the control group (59.71%±11.94% vs. 52.54%±11.86%; 36.46%±7.60% vs. 31.58%±10.23%; 18.40%±8.82% vs. 23.07%±7.30%; 2.38±1.14 vs. 1.54±0.80

respectively; all P<0.05). The expression of HLA-DR significantly increased after treatment in the intervention group than that in the control group (7.28%±9.26% vs. 1.27%±7.00%; P<0.01). Electro-acupuncture at Zusanli and Guanyuan could improve clinical curative effect in patients with sepsis

which might be achieved by regulation of the immune system.

Abstract

To evaluate the effect of electro-acupuncture on Zusanli (ST 36)

Guanyuan (RN 4) in patients with sepsis

and explore its mechanism in term of immune regulation. In this prospective randomized controlled trial

respectively. The mortality at 28 days

Acute Physiology and Chronic Health Evaluation (APACHE)-II score were compared to evaluate the effect

and the levels of T cell subsets (CD3+

CD4+

CD8+

with 5 death of 29 patients in the intervention group (17.2%) and 9 of 29 in the control group (31.0%). After treatment

APACHE-II score of both groups was significantly decreased

however

score of the intervention group was lower than the control group (13.28±7.07 vs. 17.10±5.83; P<0.01). The levels of CD3+

CD4+

which might be achieved by regulation of the immune system.

关键词

sepsiselectro-acupunctureST36RN4immunohematologyclinical trial

Keywords

sepsiselectro-acupunctureST36RN4immunohematologyclinical trial

references

Lagu T, Rothberg MB, Shieh MS, Pekow PS, Steingrub JS, Lindenauer PK. Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007. Crit Care Med 2012;40:1–8.

Cohen J. The immunopathogenesis of sepsis. Nature 2002;420:885–891.

Xie S, Ling X. Regulative effects of auricular acupuncture, moxibustion and Chinese herbs on immunologic function in the D-galactose-induced aging mouse. J Acupunct Tuina Sci 2011;9:142–144.

Wu JN, Wu W. Effect of electro-acupuncture treatment on the immune function of patients with sepsis. J Zhejiang Chin Med Univ (Chin) 2013;37:768–770.

Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Crit Care Med 2003;31:1250–1256.

Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intens Care Med 2013;39:165–228.

Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE: a severity of disease classification system. Crit Care Med 1985;10:818–829.

Zhang J, Feng D, She DY, Xie LX. The clinical application value of severity and prognosis scoring system for patients with sepsis. Acad J Pla Postgrad Med Sch (Chin) 2011;2:225–227.

Condotta SA, Cabrera-Perez J, Badovinac VP, Griffith TS. T-cell-mediated immunity and the role of TRAIL in sepsis-induced immunosuppression. Crit Rev Immunol 2013;33:23–40.

Kavoussi B, Ross BE. Neuroimmune basis of anti-inflammatory acupuncture. Integr Cancer Therap 2007;6:251–257.

Chen WF, Wen Y, Medical immunology. Beijing: People's Medical Publishing House; 2003:98–101.

Zhao NX, Gao W, Huang YX. Effects of electro-acupuncture of "Zusanli" on T lymphocyte subsets in rats. Acupunct Res (Chin) 2001;26:15–18.

Gao W, Huang YX, Chen H, Zhang HX, Sun DY, Wang QL. Effects of electroacupuncture of "Zusanli" on braingut peptide contents in rat pituitary gland and peripheral blood and on the immune system. Acupuncture Res (Chin) 2002;27:50–55.

Todd RT, Nadler LM, Schlossman SF. Antigens on human monocytesidentified by monoclonal antibodies. J Immunol 1981;126:1435–1442.

Cooperative Group of Immunomodulatory Therapy of Sepsis. Clinical trial with a new immunomodulatory strategy: treatment of severe sepsis with Ulinastalin and Maipuxin. Chin Med J (Chin) 2007;87:451–457.

Volk HD, Reinke P, Krausch D, Zuckermann H, Asadullah K, Muller JM, et al. Monocyte deactivation—rationale for a new therapeutic strategy in sepsis. Intens Care Med 1996;22:474–481.

Yang XG, Li Y, Tian XP, Liang FR. Review of method in selecting non-acupoint in acupuncture research at home and abroad. J Tradit Chin Med (Chin) 2009;50:748–750.

FULL TEXT LINK

More>

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Effect of chinese traditional healthcare exercises on 136 junior school students

Review of the regulations for clinical research in herbal medicines in USA

Anti-inflammatory effect of Qingwen Baidu Decoction (清瘟败毒饮) in sepsis rats

Evaluating the effectiveness of electro-acupuncture as a treatment for childhood autism using single photon emission computed tomography

Effects of electroacupuncture on muscle state and electrophysiological changes in rabbits with lumbar nerve root compression