Effect of integrated Chinese and Western medicine therapy on severe hand, foot and mouth disease: A prospective, randomized, controlled trial

Xiu-hui Li; Shuang-jie Li; Yi Xu; Dan Wei; Qing-sheng Shi; Qing-xiong Zhu; Tong Yang; Jian-bo Ding; Yi-mei Tian; Ji-han Huang; Kun Wang; Tao Wen; Xi Zhang

doi:10.1007/s11655-016-2504-3

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Effect of integrated Chinese and Western medicine therapy on severe hand, foot and mouth disease: A prospective, randomized, controlled trial

OriginalPaper | Updated：2021-08-27

- Effect of integrated Chinese and Western medicine therapy on severe hand, foot and mouth disease: A prospective, randomized, controlled trial
- Effect of integrated Chinese and Western medicine therapy on severe hand, foot and mouth disease: A prospective, randomized, controlled trial
- 中国结合医学杂志（英文版） 2017年23卷第12期页码：887-892
- Affiliations：
  
  1. Department of Integrated Traditional Chinese Medicine and Western Medicine, Beijing Youan Hospital Affiliated to Capital Medical University,Beijing,China
  2. Department of Communicable Diseases, Children’s Hospital of Hunan Province,Changsha,China
  3. Department of Pediatrics, Guangzhou Medical Center for Women and Children,Guangzhou,China
  4. Department of Pediatrics, First Hospital Affiliated to Guangxi Medical University,Nanning,China
  5. Department of Internal Medicine, Handan Maternal and Child Health Hospital,Hebei Province,Handan,China
  6. Department of Internal Medicine, Children’s Hospital of Jiangxi Province,Nanchang,China
  7. Department of Pediatrics, The People’s Hospital of Liuzhou,Guangxi Province,Liuzhou,China
  8. Center for Drug Clinical Research, Shanghai University of Chinese Medicine,Shanghai,China
  9. Medical Research Center, Beijing Chaoyang Hospital, Capital Medical University,Beijing,China
  10. Department of Pediatrics, Kaifeng Children’s Hospital,Henan Province,Kaifeng,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-016-2504-3
  中图分类号：
- 纸质出版日期：2017，
  
  网络出版日期：2016-7-9，
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Li, Xh., Li, Sj., Xu, Y. et al. Effect of integrated Chinese and Western medicine therapy on severe hand, foot and mouth disease: A prospective, randomized, controlled trial., Chin. J. Integr. Med. 23, 887–892 (2017). https://doi.org/10.1007/s11655-016-2504-3

Xiu-hui Li, Shuang-jie Li, Yi Xu, et al. Effect of integrated Chinese and Western medicine therapy on severe hand, foot and mouth disease: A prospective, randomized, controlled trial[J]. Chinese Journal of Integrative Medicine, 2017,23(12):887-892.
Li, Xh., Li, Sj., Xu, Y. et al. Effect of integrated Chinese and Western medicine therapy on severe hand, foot and mouth disease: A prospective, randomized, controlled trial., Chin. J. Integr. Med. 23, 887–892 (2017). https://doi.org/10.1007/s11655-016-2504-3 DOI：

Xiu-hui Li, Shuang-jie Li, Yi Xu, et al. Effect of integrated Chinese and Western medicine therapy on severe hand, foot and mouth disease: A prospective, randomized, controlled trial[J]. Chinese Journal of Integrative Medicine, 2017,23(12):887-892. DOI： 10.1007/s11655-016-2504-3.

摘要

To evaluate the efficacy and safety of Chinese medicine (CM) plus Western medicine (WM) in the treatment of pediatric patients with severe hand

foot and mouth disease (HFMD) by conducting a prospective

controlled

and randomized trial. A total of 451 pediatric patients with severe HFMD were randomly assigned to receive WM therapy alone (224 cases

WM therapy group) or CM [Reduning Injection (热毒宁注射液) or Xiyanping Injection (喜炎平注射液)] plus WM therapy (227 cases

CM plus WM therapy group) for 7–10 days

according to a web-based randomization system. The primary outcome was fever clearance time

which was presented as temperature decreased half-life time. The secondary outcomes included the rate of rash/herpes disappearance within 120 h

as well as the rate for cough

runny nose

lethargy and weakness

agitation or irritability

and vomiting clearance within 120 h. The drug-related adverse events were also recorded. The temperature decreased half-life time was 40.4 h in the WM therapy group

significantly longer than 27.2 h in the CM plus WM therapy group (P<0.01). Moreover

the rate for rash/herpes disappearance within 120 h was 43.6% (99/227) in the CM plus WM therapy group

significantly higher than 29.5% (66/224) in the WM therapy group (P<0.01). In addition

the rate for cough

lethargy and weakness

agitation or irritability disappearance within 120 h was 32.6% (74/227) in the CM plus WM therapy group

significantly higher than 19.2% (43/224) in the WM therapy group (P<0.01). No drug-related adverse events were observed during the course of the study. The combined CM and WM therapy achieved a better therapeutic efficacy in treating severe HFMD than the WM therapy alone. Reduning or Xiyanping Injections may become an important complementary therapy to WM for relieving the symptoms of severe HFMD. (Registration No. NCT01145664)

Abstract

To evaluate the efficacy and safety of Chinese medicine (CM) plus Western medicine (WM) in the treatment of pediatric patients with severe hand

foot and mouth disease (HFMD) by conducting a prospective

controlled

and randomized trial. A total of 451 pediatric patients with severe HFMD were randomly assigned to receive WM therapy alone (224 cases

WM therapy group) or CM [Reduning Injection (热毒宁注射液) or Xiyanping Injection (喜炎平注射液)] plus WM therapy (227 cases

CM plus WM therapy group) for 7–10 days

according to a web-based randomization system. The primary outcome was fever clearance time

which was presented as temperature decreased half-life time. The secondary outcomes included the rate of rash/herpes disappearance within 120 h

as well as the rate for cough

runny nose

lethargy and weakness

agitation or irritability

and vomiting clearance within 120 h. The drug-related adverse events were also recorded. The temperature decreased half-life time was 40.4 h in the WM therapy group

significantly longer than 27.2 h in the CM plus WM therapy group (P<0.01). Moreover

the rate for rash/herpes disappearance within 120 h was 43.6% (99/227) in the CM plus WM therapy group

significantly higher than 29.5% (66/224) in the WM therapy group (P<0.01). In addition

the rate for cough

lethargy and weakness

agitation or irritability disappearance within 120 h was 32.6% (74/227) in the CM plus WM therapy group

关键词

handfoot and mouth diseaseReduning InjectionXiyanping InjectionChinese Medicine

Keywords

handfoot and mouth diseaseReduning InjectionXiyanping InjectionChinese Medicine

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