Is manipulative therapy clinically necessary for relief of neck pain? A systematic review and meta-analysis

Min Yao; Yue-li Sun; Rong-liang Dun; Tian-ying Lan; Jin-long Li; Hyo Jin Lee; Noriko Haraguchi; Yong-jun Wang; Xue-jun Cui

doi:10.1007/s11655-016-2506-1

Your Location：

Home >

Browse articles >

Is manipulative therapy clinically necessary for relief of neck pain? A systematic review and meta-analysis

OriginalPaper | Updated：2021-08-27

- Is manipulative therapy clinically necessary for relief of neck pain? A systematic review and meta-analysis
- Is manipulative therapy clinically necessary for relief of neck pain? A systematic review and meta-analysis
- 中国结合医学杂志（英文版） 2017年23卷第7期页码：543-554
- Affiliations：
  
  1. Institute of Spine Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine,Shanghai,China
  2. Yueyang College of Clinical Medicine, Shanghai University of Traditional Chinese Medicine,Shanghai,China
  3. Shuguang College of Clinical Medicine, Shanghai University of Traditional Chinese Medicine,Shanghai,China
  4. Longhua College of Clinical Medicine, Shanghai University of Traditional Chinese Medicine,Shanghai,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 81373666), Municipal Hospitals Cutting-Edge Technologies Emerging Joint Project (No. SHDC12013113), Municipal Science and Technology Commission of Shanghai Chinese Medicine Key Project (No.14401970400), National Research Projects of the State Administration of Traditional Chinese Medicine (No. 201407001-2), Traditional Chinese Medicine Research Foundation (No. 2012L032A), and Special Project of Scientific Research Base by State Administration of Traditional Chinese Medicine (No. JDZX2012118), China
- DOI：10.1007/s11655-016-2506-1
  中图分类号：
- 纸质出版日期：2017，
  
  网络出版日期：2016-8-2，
Scan for full text
Yao, M., Sun, Yl., Dun, Rl. et al. Is manipulative therapy clinically necessary for relief of neck pain? A systematic review and meta-analysis., Chin. J. Integr. Med. 23, 543–554 (2017). https://doi.org/10.1007/s11655-016-2506-1

Min Yao, Yue-li Sun, Rong-liang Dun, et al. Is manipulative therapy clinically necessary for relief of neck pain? A systematic review and meta-analysis[J]. Chinese Journal of Integrative Medicine, 2017,23(7):543-554.
Yao, M., Sun, Yl., Dun, Rl. et al. Is manipulative therapy clinically necessary for relief of neck pain? A systematic review and meta-analysis., Chin. J. Integr. Med. 23, 543–554 (2017). https://doi.org/10.1007/s11655-016-2506-1 DOI：

Min Yao, Yue-li Sun, Rong-liang Dun, et al. Is manipulative therapy clinically necessary for relief of neck pain? A systematic review and meta-analysis[J]. Chinese Journal of Integrative Medicine, 2017,23(7):543-554. DOI： 10.1007/s11655-016-2506-1.

摘要

To summarize and critically assess the effificacy of Eastern and Western manipulative therapies for the treatment of neck pain in adults. A search of PubMed/MEDLINE

the Cochrane Central Register of Controlled Trials

ClinicalTrials.gov

EMBASE

etc. from their inception date to January 2014 with Chinese

Japanese

and Korean databases. Two reviewers independently selected randomized controlled trials (RCTs) with negative control or blank control

extracted data and assessed methodological quality. Meta-analysis and levels of evidence were performed by Revman5.1 and Grades of Recommendations Assessment

Development and Evaluation (GRADE) approach. Nineteen clinical trials with adequate randomization were included in this review

11 of them had a low risk of bias. The primary outcome for short-term pain had no significant differences

however

the secondary outcome

only the Numerical Pain Rating Scale (NPRS) score of intermediate-term [n=916

pooled mean differences (MD) =–0.29

P=0.02]

the Neck Disability Index (NDI) score of short-term (n=1

145

pooled MD=–2.10

P<0.01)

and intermediate-term (n=987

pooled MD=–1.45

P=0.01) were signifificantly reduced with moderate quality evidence. However

it supported the minimally clinically important difference (MCID) of the Visual Analogue Scale and NPRS pain score to be 13 mm

while NDI was 3.5 points. The meta-analysis only suggested a trend in favor of manipulative therapy rather than clinical signifificance. The results do not support the existing evidences for the clinical value of Eastern or Western manipulative therapy for neck pain of short-term follow-up according to MCIDs. The limitations of our review related to blinding

allocation concealment and small sample size.

Abstract

To summarize and critically assess the effificacy of Eastern and Western manipulative therapies for the treatment of neck pain in adults. A search of PubMed/MEDLINE

the Cochrane Central Register of Controlled Trials

ClinicalTrials.gov

EMBASE

etc. from their inception date to January 2014 with Chinese

Japanese

and Korean databases. Two reviewers independently selected randomized controlled trials (RCTs) with negative control or blank control

extracted data and assessed methodological quality. Meta-analysis and levels of evidence were performed by Revman5.1 and Grades of Recommendations Assessment

Development and Evaluation (GRADE) approach. Nineteen clinical trials with adequate randomization were included in this review

11 of them had a low risk of bias. The primary outcome for short-term pain had no significant differences

however

the secondary outcome

only the Numerical Pain Rating Scale (NPRS) score of intermediate-term [n=916

pooled mean differences (MD) =–0.29

P=0.02]

the Neck Disability Index (NDI) score of short-term (n=1

145

pooled MD=–2.10

P<0.01)

and intermediate-term (n=987

pooled MD=–1.45

P=0.01) were signifificantly reduced with moderate quality evidence. However

it supported the minimally clinically important difference (MCID) of the Visual Analogue Scale and NPRS pain score to be 13 mm

allocation concealment and small sample size.

关键词

systematic reviewmeta-analysismanipulative therapyneck painminimally clinically important difference

Keywords

systematic reviewmeta-analysismanipulative therapyneck painminimally clinically important difference

references

Haldeman S, Carroll L, Cassidy JD. Findings from the bone and joint decade 2000 to 2010 task force on neck pain and its associated disorders. J Occup Environ Med 2010;52:424–427.

Hogg-Johnson S, van der Velde G, Carroll LJ, Holm LW, Cassidy JD, Guzman J, et al. The burden and determinants of neck pain in the general population: results of the Bone and Joint Decade 2000–2010 Task Force on Neck Pain and Its Associated Disorders. Spine 2008;33(4 Suppl):S39–S51.

Martin BI, Deyo RA, Mirza SK, Turner JA, Comstock BA, Hollingworth W, et al. Expenditures and health status among adults with back and neck problems. JAMA 2008;299:656–664.

Côté P, Cassidy JD, Carroll L. The Saskatchewan Health and Back Pain Survey. The prevalence of neck pain and related disability in Saskatchewan adults. Spine 1998;23:1689–1698.

Côté P, Kristman V, Vidmar M, van Eerd D, Hogg-Johnson S, Beaton D, et al. The prevalence and incidence of work absenteeism involving neck pain: a cohort of Ontario losttime claimants. Spine 2008;33(4 Suppl):S192–S198.

Côté P, van der Velde G, Cassidy JD, Carroll LJ, Hogg-Johnson S, Holm LW, et al. The burden and determinants of neck pain in workers: results of the Bone and Joint Decade 2000–2010 Task Force on Neck Pain and Its Associated Disorders. Spine 2008;33(4 Suppl):S60–S74.

Luime JJ, Kuiper JI, Koes BW, Verhaar JA, Miedema HS, Burdorf A. Work-related risk factors for the incidence and recurrence of shoulder and neck complaints among nursing-home and elderly-care workers. Scand J Work Environ Health 2004;30:279–286.

Croft PR, Lewis M, Papageorgiou AC, Thomas E, Jayson MI, Macfarlane GJ, et al. Risk factors for neck pain: a longitudinal study in the general population. Pain 2001;93:317–325.

Wieser ES, Wang JC. Surgery for neck pain. Neurosurgery 2007;60(Suppl 1):S51–S56.

Vernon H, Humphreys BK. Manual therapy for neck pain: an overview of randomized clinical trials and systematic reviews. Eur Medicophys 2007;43:91–118.

Cassidy JD, Bronfort G, Hartvigsen J. Should we abandon cervical spine manipulation for mechanical neck pain? No. BMJ 2012;344:e3680.

Wand BM, Heine PJ, O'Connell NE. Should we abandon cervical spine manipulation for mechanical neck pain? Yes. BMJ 2012;344:e3679.

Cassidy JD, Boyle E, Côté P, He Y, Hogg-Johnson S, Silver FL, et al. Risk of vertebrobasilar stroke and chiropractic care: results of a population-based case-control and casecrossover study. Spine 2008;33(4 Suppl):S176–S183.

Ernst E. Vascular accidents after neck manipulation: cause or coincidence? Int J Clin Pract 2010;64:673–677.

Kawchuk GN, Jhangri GS, Hurwitz EL, Wynd S, Haldeman S, Hill MD. The relation between the spatial distribution of vertebral artery compromise and exposure to cervical manipulation. J Neurol 2008;255:371–377.

Thomas LC, Rivett DA, Attia JR, Parsons M, Levi C. Risk factors and clinical features of craniocervical arterial dissection. Man Ther 2011;16:351–356.

Vernon H, Humphreys K, Hagino C. Chronic mechanical neck pain in adults treated by manual therapy: a systematic review of change scores in randomized clinical trials. J Manipulative Physiol Ther 2007;30:215–227.

Miller J, Gross A, D'Sylva J, Burnie SJ, Goldsmith CH, Graham N, et al. Manual therapy and exercise for neck pain: a systematic review. Man Ther 2010;15:334–354.

Gross A, Miller J, D'Sylva J, Burnie SJ, Goldsmith CH, Graham N, et al. Manipulation or mobilisation for neck pain. Cochrane Database Syst Rev 2010(1):CD004249. DOI:10.1002/14651858.CD004249.pub3.

Gross AR, Hoving JL, Haines TA, Goldsmith CH, Kay T, Aker P, et al. Manipulation and mobilisation for mechanical neck disorders. Cochrane Database Syst Rev 2004(1):CD004249. DOI: 10.1002/14651858.CD004249.pub2.

Fang L, Fang M. Research progress on the standardization of Chinese Tuina therapy: a short review. Chin J Integr Med 2013;19:68–72.

Powell CV, Kelly AM, Williams A. Determining the minimum clinically significant difference in visual analog pain score for children. Ann Emerg Med 2001;37:28–31.

Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol 2009;62:e1–e34.

Tao KM, Li XQ, Zhou QH, Moher D, Ling CQ, Yu WF. From QUOROM to PRISMA: a survey of high-impact medical journals' instructions to authors and a review of systematic reviews in anesthesia literature. PLoS One 2011;6:e27611.

Higgins JPT, Green S, eds. Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated March 2011]. The Cochrane Collaboration. 2011; Available at: http://www.cochrane-handbook.org.

Furlan AD, Pennick V, Bombardier C, van Tulder M. 2009 updated method guidelines for systematic reviews in the Cochrane Back Review Group. Spine 2009;34:1929–1941.

Bijur PE, Silver W, Gallagher EJ. Reliability of the visual analog scale for measurement of acute pain. Acad Emerg Med 2001;8:1153–1157.

Hurwitz EL, Morgenstern H, Harber P, Kominski GF, Yu F, Adams AH. A randomized trial of chiropractic manipulation and mobilization for patients with neck pain: clinical outcomes from the UCLA neck-pain study. Am J Public Health 2002;92:1634–1641.

Kremer E, Atkinson JH, Ignelzi RJ. Measurement of pain: patient preference does not confound pain measurement. Pain 1981;10:241–248.

Jensen MP, Karoly P, Braver S. The measurement of clinical pain intensity: a comparison of six methods. Pain 1986;27:117–126.

Farrar JT, Young JP Jr., LaMoreaux L, Werth JL, Poole RM. Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale. Pain 2001;94:149–158.

Closs SJ, Barr B, Briggs M, Cash K, Seers K. A comparison of five pain assessment scales for nursing home residents with varying degrees of cognitive impairment. J Pain Symptom Manage 2004;27:196–205.

Pietrobon R, Coeytaux RR, Carey TS, Richardson WJ, DeVellis RF. Standard scales for measurement of functional outcome for cervical pain or dysfunction: a systematic review. Spine 2002;27:515–522.

Cleland JA, Childs JD, Whitman JM. Psychometric properties of the Neck Disability Index and Numeric Pain Rating Scale in patients with mechanical neck pain. Arch Phys Med Rehabil 2008;89:69–74.

Moreno SG, Sutton AJ, Turner EH, Abrams KR, Cooper NJ, Palmer TM, et al. Novel methods to deal with publication biases: secondary analysis of antidepressant trials in the FDA trial registry database and related journal publications. BMJ 2009;339:b2981.

Atkins D, Best D, Briss PA, Eccles M, Falck-Ytter Y, Flottorp S, et al. Grading quality of evidence and strength of recommendations. BMJ 2004;328:1490–1494.

Groeneweg R, Kropman H, Leopold H, van Assen L, Mulder J, van Tulder MW, et al. The effectiveness and cost-evaluation of manual therapy and physical therapy in patients with sub-acute and chronic non specific neck pain. Rationale and design of a randomized controlled trial (RCT). BMC Musculoskelet Disord 2010;11:14.

Maiers MJ, Hartvigsen J, Schulz C, Schulz K, Evans RL, Bronfort G. Chiropractic and exercise for seniors with low back pain or neck pain: the design of two randomized clinical trials. BMC Musculoskelet Disord 2007;8:94.

Sherman KJ, Cook AJ, Kahn JR, Hawkes RJ, Wellman RD, Cherkin DC. Dosing study of massage for chronic neck pain: protocol for the dose response evaluation and analysis of massage [DREAM] trial. BMC Complement Altern Med 2012;12:158.

Bronfort G, Evans R, Nelson B, Aker PD, Goldsmith CH, Vernon H. A randomized clinical trial of exercise and spinal manipulation for patients with chronic neck pain. Spine 2001;26:788–797.

Bronfort G, Evans R, Anderson AV, Svendsen KH, Bracha Y, Grimm RH. Spinal manipulation, medication, or home exercise with advice for acute and subacute neck pain: a randomized trial. Ann Intern Med 2012;156:1–10.

Cleland JA, Mintken PE, Carpenter K, Fritz JM, Glynn P, Whitman J, et al. Examination of a clinical prediction rule to identify patients with neck pain likely to benefit from thoracic spine thrust manipulation and a general cervical range of motion exercise: multi-center randomized clinical trial. Phys Ther 2010;90:1239–1250.

Dziedzic K, Hill J, Lewis M, Sim J, Daniels J, Hay EM. Effectiveness of manual therapy or pulsed shortwave diathermy in addition to advice and exercise for neck disorders: a pragmatic randomized controlled trial in physical therapy clinics. Arthritis Rheum 2005;53:214–222.

Evans R, Bronfort G, Nelson B, Goldsmith CH. Two-year follow-up of a randomized clinical trial of spinal manipulation and two types of exercise for patients with chronic neck pain. Spine 2002;27:2383–2389.

Evans R, Bronfort G, Schulz C, Maiers M, Bracha Y, Svendsen K, et al. Supervised exercise with and without spinal manipulation performs similarly and better than home exercise for chronic neck pain: a randomized controlled trial. Spine 2012;37:903–914.

Fernández-de-las-Peñas C, Cleland JA, Huijbregts P, Palomeque-Del-Cerro L, González-Iglesias J. Repeated applications of thoracic spine thrust manipulation do not lead to tolerance in patients presenting with acute mechanical neck pain: a secondary analysis. J Man Manip Ther 2009;17:154–162.

González-Iglesias J, Fernández-de-las-Peñas C, Cleland JA, Alburquerque-Sendin F, Palomeque-del-Cerro L, Mendez-Sanchez R. Inclusion of thoracic spine thrust manipulation into an electro-therapy/thermal program for the management of patients with acute mechanical neck pain: a randomized clinical trial. Man Ther 2009;14:306–313.

González-Iglesias J, Fernández-de-las-Peñas C, Cleland JA, Gutiérrez-Vega Mdel R. Thoracic spine manipulation for the management of patients with neck pain: a randomized clinical trial. J Orthop Sports Phys Ther 2009;39:20–27.

Haas M, Groupp E, Panzer D, Partna L, Lumsden S, Aickin M. Efficacy of cervical endplay assessment as an indicator for spinal manipulation. Spine 2003;28:1091–1096.

Jellad A, Ben Salah Z, Boudokhane S, Migaou H, Bahri I, Rejeb N. The value of intermittent cervical traction in recent cervical radiculopathy. Ann Phys Rehabil Med 2009;52:638–652.

Lau HM, Wing Chiu TT, Lam TH. The effectiveness of thoracic manipulation on patients with chronic mechanical neck pain—a randomized controlled trial. Man Ther 2011;16:141–147.

Pool JJ, Ostelo RW, Knol DL, Vlaeyen JW, Bouter LM, de Vet HC. Is a behavioral graded activity program more effective than manual therapy in patients with subacute neck pain? Results of a randomized clinical trial. Spine 2010;35:1017–1024.

Saayman L, Hay C, Abrahamse H. Chiropractic manipulative therapy and low-level laser therapy in the management of cervical facet dysfunction: a randomized controlled study. J Manipulative Physiol Ther 2011;34:153–163.

Sherman KJ, Cherkin DC, Hawkes RJ, Miglioretti DL, Deyo RA. Randomized trial of therapeutic massage for chronic neck pain. Clin J Pain 2009;25:233–238.

Sillevis R, Cleland J, Hellman M, Beekhuizen K. Immediate effects of a thoracic spine thrust manipulation on the autonomic nervous system: a randomized clinical trial. J Man Manip Ther 2010;18:181–190.

Walker MJ, Boyles RE, Young BA, Strunce JB, Garber MB, Whitman JM, et al. The effectiveness of manual physical therapy and exercise for mechanical neck pain: a randomized clinical trial. Spine 2008;33:2371–2378.

Ylinen J, Kautiainen H, Wiren K, Hakkinen A. Stretching exercises vs manual therapy in treatment of chronic neck pain: a randomized, controlled cross-over trial. J Rehabil Med 2007;39:126–132.

Zhou XP, He JT. Study on the analgesic effect of acupuncture plus Long's manipulation on nerve root-type cervical spondylopathy. Shanghai J Acupunct Moxibust (Chin) 2007;26:12–14.

Todd KH. Patient-oriented outcome measures: the promise of definition. Ann Emerg Med 2001;38:672–674.

Salaffi F, Stancati A, Silvestri CA, Ciapetti A, Grassi W. Minimal clinically important changes in chronic musculoskeletal pain intensity measured on a numerical rating scale. Eur J Pain 2004;8:283–291.

Kelly AM. The minimum clinically significant difference in visual analogue scale pain score does not differ with severity of pain. Emerg Med J 2001;18:205–207.

Hagg O, Fritzell P, Nordwall A. The clinical importance of changes in outcome scores after treatment for chronic low back pain. Eur Spine J 2003;12:12–20.

Bird SB, Dickson EW. Clinically significant changes in pain along the visual analog scale. Ann Emerg Med 2001;38:639–643.

Pool JJ, Ostelo RW, Hoving JL, Bouter LM, de Vet HC. Minimal clinically important change of the Neck Disability Index and the Numerical Rating Scale for patients with neck pain. Spine 2007;32:3047–3051.

D'Sylva J, Miller J, Gross A, Burnie SJ, Goldsmith CH, Graham N, et al. Manual therapy with or without physical medicine modalities for neck pain: a systematic review. Man Ther 2010;15:415–433.

Pittler MH, Abbot NC, Harkness EF, Ernst E. Location bias in controlled clinical trials of complementary/alternative therapies. J Clin Epidemiol 2000;53:485–489.

Rerkasem K, Rothwell PM. Meta-analysis of small randomized controlled trials in surgery may be unreliable. Br J Surg 2010;97:466–469.

Kjaergard LL, Villumsen J, Gluud C. Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses. Ann Intern Med 2001;135:982–989.

Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias: dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA 1995;273:408–412.

Moher D, Pham B, Jones A, Cook DJ, Jadad AR, Moher M, et al. Does quality of reports of randomised trials affect estimates of intervention efficacy reported in metaanalyses? Lancet 1998;352:609–613.

Juni P, Altman D, Egger M. Assessing quality of controlled trials. BMJ 2001;323:42–46.

Schulz KF, Altman DG, Moher D. CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials. Ann Intern Med 2010;152:726–732.

Begg C, Cho M, Eastwood S, Horton R, Moher D, Olkin I, et al. Improving the quality of reporting of randomized controlled trials. The CONSORT statement. JAMA 1996;276:637–639.

FULL TEXT LINK

More>

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

A systematic review and meta-analysis of type 2 diabetes mellitus treatment based on the “three-typed syndrome differentiation” theory in Chinese medicine

Individual patient data meta-analysis is needed in Chinese medical research

Red ginseng for type 2 diabetes mellitus: A systematic review of randomized controlled trials

Is Chinese herbal medicine effective for elderly isolated systolic hypertension? A systematic review and meta-analysis

Efficacy and safety of Flos Abelmoschus manihot (Malvaceae) on type 2 diabetic nephropathy: A systematic review