Bawu decoction (八物汤) ameliorates benign prostatic hyperplasia in rats

Ji-Hwan Eom; Se-Yun Cheon; Kyung-Sook Chung; Myung-Dong Kim; Hyo-Jin An

doi:10.1007/s11655-016-2528-8

Your Location：

Home >

Browse articles >

Bawu decoction (八物汤) ameliorates benign prostatic hyperplasia in rats

OriginalPaper | Updated：2021-08-27

- Bawu decoction (八物汤) ameliorates benign prostatic hyperplasia in rats
- Bawu decoction (八物汤) ameliorates benign prostatic hyperplasia in rats
- 中国结合医学杂志（英文版） 2017年23卷第8期页码：611-616
- Affiliations：
  
  1. Department of Physiology, College of Korean Medicine, Sangji University, Wonju-si Gangwon-do, Republic of Korea
  2. Department of Pharmacology, College of Korean Medicine, Sangji University, Wonju-si Gangwon-do, Republic of Korea
- Author bio：
- Funds：
  
  Supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning(NRF- 2016R1C1B2011827)
- DOI：10.1007/s11655-016-2528-8
  中图分类号：
- 纸质出版日期：2017，
  
  网络出版日期：2016-11-12，
Scan for full text
Eom, JH., Cheon, SY., Chung, KS. et al. Bawu decoction (八物汤) ameliorates benign prostatic hyperplasia in rats., Chin. J. Integr. Med. 23, 611–616 (2017). https://doi.org/10.1007/s11655-016-2528-8

Ji-Hwan Eom, Se-Yun Cheon, Kyung-Sook Chung, et al. Bawu decoction (八物汤) ameliorates benign prostatic hyperplasia in rats[J]. Chinese Journal of Integrative Medicine, 2017,23(8):611-616.
Eom, JH., Cheon, SY., Chung, KS. et al. Bawu decoction (八物汤) ameliorates benign prostatic hyperplasia in rats., Chin. J. Integr. Med. 23, 611–616 (2017). https://doi.org/10.1007/s11655-016-2528-8 DOI：

Ji-Hwan Eom, Se-Yun Cheon, Kyung-Sook Chung, et al. Bawu decoction (八物汤) ameliorates benign prostatic hyperplasia in rats[J]. Chinese Journal of Integrative Medicine, 2017,23(8):611-616. DOI： 10.1007/s11655-016-2528-8.

摘要

To evaluate the efficacy of Bawu Decoction (八物汤

BWD

Palmul-tang in Korean) against benign prostatic hyperplasia (BPH). Twenty-four male Wistar rats were divided into 4 groups

with 6 rats in each group. The 4 study groups included sham-operated group (CON)

BPH model group

fifinasteride-treated group

and BWD-treated group. All the groups except CON group received a subcutaneous injection of 10 mg/kg of testosterone

while CON group received saline. Finasteride at a dose of 5 mg/kg was administered to the finasteride-treated group for a period of 4 weeks. BWD group received BWD at a dose of 200 mg/kg for 4 weeks. The prostatic weight

prostate weight to body weight ratio

relative prostate weight ratio

serum testosterone and dihydrotestosterone (DHT) level

and histological analysis of prostatic tissue were analyzed. Compared to BPH model group

BWD administration was associated with reductions in prostatic weight

prostate and relative prostate weight ratio weight to body weight ratio (P<0.05). The concentration of serum testosterone and DHT were higher in BPH group compared with CON group (P<0.05). Administration of finasteride and BWD suppressed the elevation of serum testosterone and DHT levels signifificantly (both P<0.05). In addition

BWD suppressed the growth of prostatic tissue (P<0.05). BWD has suppressant effects on development of BPH through inhibition of serum testosterone and DHT.

Abstract

To evaluate the efficacy of Bawu Decoction (八物汤

BWD

Palmul-tang in Korean) against benign prostatic hyperplasia (BPH). Twenty-four male Wistar rats were divided into 4 groups

with 6 rats in each group. The 4 study groups included sham-operated group (CON)

BPH model group

fifinasteride-treated group

and BWD-treated group. All the groups except CON group received a subcutaneous injection of 10 mg/kg of testosterone

prostate weight to body weight ratio

relative prostate weight ratio

serum testosterone and dihydrotestosterone (DHT) level

and histological analysis of prostatic tissue were analyzed. Compared to BPH model group

BWD administration was associated with reductions in prostatic weight

BWD suppressed the growth of prostatic tissue (P<0.05). BWD has suppressant effects on development of BPH through inhibition of serum testosterone and DHT.

关键词

benign prostatic hyperplasiaBawu DecotionPalmul-tangfinasterideTestosteronedihydrotesteronerat

Keywords

benign prostatic hyperplasiaBawu DecotionPalmul-tangfinasterideTestosteronedihydrotesteronerat

references

de Lourdes Arruzazabala M, Molina V, Mas R, Carbajal D, Marrero D, Gonzalez V, et al. Effects of coconut oil on testosterone-induced prostatic hyperplasia in Sprague-Dawley rats. J Pharm Pharmacol 2007;59:995–999.

Keoghane SR. Quality of life assessment in patients after laser prostatectomy. Br J Urol 1998;81:656–657.

Steenkamp V, Gouws MC, Gulumian M, Elgorashi EE, van Staden J. Studies on antibacterial, anti-inflammatory and antioxidant activity of herbal remedies used in the treatment of benign prostatic hyperplasia and prostatitis. J Ethnopharmacol 2006;103:71–75.

Isaacs JT. Etiology of benign prostatic hyperplasia. Eur Urol 1994;25 (Suppl) 1:6–9.

Thorpe A, Neal D. Benign prostatic hyperplasia. Lancet 2003;361:1359–1367.

Gee WF, Holtgrewe HL, Albertsen PC, Litwin MS, Manyak MJ, O’Leary MP, et al. Practice trends in the diagnosis and management of benign prostatic hyperplasia in the United States. J Urol 1995;154:205–206.

Djavan B, Eckersberger E, Finkelstein J, Espinosa G, Sadri H, Brandner R, et al. Benign prostatic hyperplasia: current clinical practice. Prim Care 2010;37:583–597, ix.

Lepor H. Benign prostatic hyperplasia. J Urol 1995;153:1540–1542.

Lepor H. Medical treatment of benign prostatic hyperplasia. Rev Urol 2011;13:20–33.

Untergasser G, Madersbacher S, Berger P. Benign prostatic hyperplasia: age-related tissue-remodeling. Exp Gerontol 2005;40:121–128.

Patel AK, Chapple CR. Benign prostatic hyperplasia: treatment in primary care. Br Med J 2006;333:535–539.

Uygur MC, Gur E, Arik AI, Altug U, Erol D. Erectile dysfunction following treatments of benign prostatic hyperplasia: a prospective study. Andrologia 1998;30:5–10.

McConnell JD, Roehrborn CG, Bautista OM, Andriole GL, Jr., Dixon CM, Kusek JW, et al. The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia. N Engl J Med 2003;349:2387–2398.

Bae JS, Park HS, Park JW, Li SH, Chun YS. Red ginseng and 20(S)-Rg3 control testosterone-induced prostate hyperplasia by deregulating androgen receptor signaling. J Nat Med 2012;66:476–485.

Jiang C, Lee HJ, Li GX, Guo J, Malewicz B, Zhao Y, et al. Potent antiandrogen and androgen receptor activities of an Angelica gigas-containing herbal formulation: identification of decursin as a novel and active compound with implications for prevention and treatment of prostate cancer. Cancer Res 2006;66:453–463.

Rick FG, Schally AV, Block NL, Nadji M, Szepeshazi K, Zarandi M, et al. Antagonists of growth hormone-releasing hormone (GHRH) reduce prostate size in experimental benign prostatic hyperplasia. Proc Natl Acad Sci U S A 2011;108:3755–3760.

Jeon HJ, Chung KS, An HJ. Anti-proliferation effects of Cistanches salsa on the progression of benign prostatic hyperplasia. Ca J Physiol Pharmacol 2016;94:104–111.

Maggi CA, Manzini S, Giuliani S, Meli A. Infravesical outflow obstruction in rats: a comparison of two models. Gen Pharmacol 1989;20:345–349.

Chung KS, Shin SJ, Lee NY, Cheon SY, Park W, Sun SH, et al. Anti-proliferation effects of garlic (Allium sativum L.) on the progression of benign prostatic hyperplasia. Phytother Res 2016;30:1197–1203.

Flannery MT, Ramsdell J, Ranhosky A, Davidai G, Ruoff G. Efficacy and safety of tamsulosin for benign prostatic hyperplasia: clinical experience in the primary care setting. Curr Med Res Opin 2006;22:721–730.

Kramer G, Mitteregger D, Marberger M. Is benign prostatic hyperplasia (BPH) an immune inflammatory disease? Eur Urol 2007;51:1202–1216.

Isaacs JT, Coffey DS. Etiology and disease process of benign prostatic hyperplasia. Prostate Suppl 1989;2:33–50.

Sun H, Li TJ, Sun LN, Qiu Y, Huang BB, Yi B, et al. Inhibitory effect of traditional Chinese medicine Zi-Shen Pill on benign prostatic hyperplasia in rats. J Ethnopharmacol 2008;115:203–208.

McConnell JD. The pathophysiology of benign prostatic hyperplasia. J Androl 1991;12:356–363.

Berry SJ, Strandberg JD, Saunders WJ, Coffey DS. Development of canine benign prostatic hyperplasia with age. Prostate 1986;9:363–373.

Ruska KM, Sauvageot J, Epstein JI. Histology and cellular kinetics of prostatic atrophy. Am J Surg Pathol 1998;22:1073–1077.

Bartsch G, Rittmaster RS, Klocker H. Dihydrotestosterone and the concept of 5alpha-reductase inhibition in human benign prostatic hyperplasia. World J Urol 2002;19:413–425.

Brendler CB, Berry SJ, Ewing LL, McCullough AR, Cochran RC, Strandberg JD, et al. Spontaneous benign prostatic hyperplasia in the beagle. Age-associated changes in serum hormone levels, and the morphology and secretory function of the canine prostate. J Clin Invest 1983;71:1114–1123.

Krieg M, Bartsch W, Thomsen M, Voigt KD. Androgens and estrogens: their interaction with stroma and epithelium of human benign prostatic hyperplasia and normal prostate. J Steroid Biochem 1983;19:155–161.

Li S. Exploring traditional Chinese medicine by a novel therapeutic concept of network target. Chin J Integr Med 2016;22:647–652.

Hong ZF, Lin JM, Zhong XY, Li Y, Zhou JH, Xu W, et al. Qianliening capsule (前列宁胶囊) inhibits human prostate cell growth via induction of mitochondrion-dependent cell apoptosis. Chin J Integr Med 2012;18:824–830.

Huang YP, Du J, Hong ZF, Chen ZQ, Wu JF, Zhao JY. Effects of Kangquan Recipe (康泉方) on sex steroids and cell proliferation in rats with benign prostatic hyperplasia. Chin J Integr Med 2009;15:289–292.

Joo Jinman KD, Baek Seunghee, Kim Eunha. The effect of Palmultang (八物湯) on the ovarian functions and differential gene expression of caspase-3, MAPK and MPG in female mice. J Orient Obstetr Gynecol 2007;20:91–110.

FULL TEXT LINK

More>

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Effects of Kangquan Recipe (康泉方) on sex steroids and cell proliferation in rats with benign prostatic hyperplasia

Effects of hydro-alcoholic extract of Launaea acanthodes on serum gonadotropin and testosterone levels and the structure of seminiferous tubules in hyperglycemic rats

Study on acupuncture parameters impacting on the acupuncture effect using cluster analysis in a rat model with middle cerebral artery occlusion

Clinical study on Kangquan Recipe (康泉方) for benign prostatic hyperplasia patients: A randomized controlled trial

Effect of Longbishu Capsule (癃闭舒胶囊) plus doxazosin on benign prostatic hyperplasia: A randomized controlled trial