No additional cholesterol-lowering effect observed in the combined treatment of red yeast rice and Lactobacillus casei in hyperlipidemic patients: A double-blind randomized controlled clinical trial

Chien-Ying Lee; Min-Chien Yu; Wu-Tsun Perng; Chun-Che Lin; Ming-Yung Lee; Ya-Lan Chang; Ya-Yun Lai; Yi-Ching Lee; Yu-Hsiang Kuan; James Cheng-Chung Wei; Hung-Che Shih

doi:10.1007/s11655-016-2530-1

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No additional cholesterol-lowering effect observed in the combined treatment of red yeast rice and Lactobacillus casei in hyperlipidemic patients: A double-blind randomized controlled clinical trial

OriginalPaper | Updated：2021-08-27

- No additional cholesterol-lowering effect observed in the combined treatment of red yeast rice and Lactobacillus casei in hyperlipidemic patients: A double-blind randomized controlled clinical trial
- No additional cholesterol-lowering effect observed in the combined treatment of red yeast rice and Lactobacillus casei in hyperlipidemic patients: A double-blind randomized controlled clinical trial
- 中国结合医学杂志（英文版） 2017年23卷第8期页码：581-588
- Affiliations：
  
  1. Institute of Medicine, Chung Shan Medical University, Taichung,Taiwan,China
  2. Department of Pharmacy, Chung Shan Medical University Hospital, Taichung,Taiwan,China
  3. Department of Pharmacology, Chung Shan Medical University, Taichung,Taiwan,China
  4. Department of Integrated Chinese and Western Medicine, Chung Shan Medical University Hospital, Taichung,Taiwan,China
  5. Department of Recreation Sport & Health Promotion, National Pingtung University of Science and Technology,Taiwan,China
  6. Division of Hepatogastroenterology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung,Taiwan,China
  7. Department of Statistics and Informatics Science, Providence University,Taiwan,China
  8. Department of Applied Cosmetology, National Tainan Junior College of Nursing,Taiwan,China
  9. Department of Internal Medicine, Chung Shan Medical University Hospital
  10. Graduate Institute of Integrated Medicine, China Medical University, Taichung,Taiwan,China
- Author bio：
- Funds：
  
  Supported by the Committee on Chinese Medicine and Pharmacy, Department of Health, Taiwan, China (Protocol No.: CCMP97-RD-043) and Chung Shan Medical University (Protocol No.: CSMU-INT-104-03)
- DOI：10.1007/s11655-016-2530-1
  中图分类号：
- 纸质出版日期：2017，
  
  网络出版日期：2016-11-12，
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Lee, CY., Yu, MC., Perng, WT. et al. No additional cholesterol-lowering effect observed in the combined treatment of red yeast rice and Lactobacillus casei in hyperlipidemic patients: A double-blind randomized controlled clinical trial., Chin. J. Integr. Med. 23, 581–588 (2017). https://doi.org/10.1007/s11655-016-2530-1

Chien-Ying Lee, Min-Chien Yu, Wu-Tsun Perng, et al. No additional cholesterol-lowering effect observed in the combined treatment of red yeast rice and Lactobacillus casei in hyperlipidemic patients: A double-blind randomized controlled clinical trial[J]. Chinese Journal of Integrative Medicine, 2017,23(8):581-588.
Lee, CY., Yu, MC., Perng, WT. et al. No additional cholesterol-lowering effect observed in the combined treatment of red yeast rice and Lactobacillus casei in hyperlipidemic patients: A double-blind randomized controlled clinical trial., Chin. J. Integr. Med. 23, 581–588 (2017). https://doi.org/10.1007/s11655-016-2530-1 DOI：

Chien-Ying Lee, Min-Chien Yu, Wu-Tsun Perng, et al. No additional cholesterol-lowering effect observed in the combined treatment of red yeast rice and Lactobacillus casei in hyperlipidemic patients: A double-blind randomized controlled clinical trial[J]. Chinese Journal of Integrative Medicine, 2017,23(8):581-588. DOI： 10.1007/s11655-016-2530-1.

摘要

To observe the effect of combining red yeast rice and Lactobacillus casei (L. casei) in lowering cholesterol in patients with primary hyperlipidemia

the later has also been shown to remove cholesterol in in vitro studies. A double-blind clinical trial was conducted to evaluate the cholesterol-lowering effect of the combination of red yeast rice and L. casei. Sixty patients with primary hyperlipidemia were recruited and randomized equally to either the treatment group (red yeast rice + L. casei) or the control group (red yeast rice + placebo). One red yeast rice capsule and two L. casei capsules were taken twice a day. The treatment lasted for 8 weeks

with an extended follow-up period of 4 weeks. The primary endpoint was a difference of serum low-density lipoprotein cholesterol (LDL-C) level at week 8. At week 8

the LDL-C serum level in both groups was lower than that at baseline

with a decrease of 33.85±26.66 mg/dL in the treatment group and 38.11±30.90 mg/dL in the control group; however

there was no statistical difference between the two groups (P>0.05). The total cholesterol was also lower than the baseline in both groups

yet without a statistical difference between the two groups. The only statistically signifificant difference between the two groups was the average diastolic pressure at week 12

which dropped by 2.67 mm Hg in the treatment group and increased by 4.43 mm Hg in the placebo group (P<0.05). The antihypertensive activity may be associated with L. casei. Red yeast rice can signifificantly reduce LDL-C

total cholesterol and triglyceride. The combination of red yeast rice and L. casei did not have an additional effect on lipid profifiles.

Abstract

To observe the effect of combining red yeast rice and Lactobacillus casei (L. casei) in lowering cholesterol in patients with primary hyperlipidemia

with an extended follow-up period of 4 weeks. The primary endpoint was a difference of serum low-density lipoprotein cholesterol (LDL-C) level at week 8. At week 8

the LDL-C serum level in both groups was lower than that at baseline

with a decrease of 33.85±26.66 mg/dL in the treatment group and 38.11±30.90 mg/dL in the control group; however

there was no statistical difference between the two groups (P>0.05). The total cholesterol was also lower than the baseline in both groups

yet without a statistical difference between the two groups. The only statistically signifificant difference between the two groups was the average diastolic pressure at week 12

total cholesterol and triglyceride. The combination of red yeast rice and L. casei did not have an additional effect on lipid profifiles.

关键词

red yeast riceLactobacillus caseilow-density lipoprotein cholesterolrandomized controlled trial

Keywords

red yeast riceLactobacillus caseilow-density lipoprotein cholesterolrandomized controlled trial

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