Changes of QT Dispersion in Hemodialysis Patients after Administrating Zhigancao Decoction (炙甘草汤)

Yan-qing Tong; Min Sun; Chun-jie Hu; Dong-kai Zhao

doi:10.1007/s11655-016-2599-6

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Changes of QT Dispersion in Hemodialysis Patients after Administrating Zhigancao Decoction (炙甘草汤)

OriginalPaper | Updated：2021-08-27

- Changes of QT Dispersion in Hemodialysis Patients after Administrating Zhigancao Decoction (炙甘草汤)
- Changes of QT Dispersion in Hemodialysis Patients after Administrating Zhigancao Decoction (炙甘草汤)
- 中国结合医学杂志（英文版） 2018年24卷第8期页码：627-631
- Affiliations：
  
  Department of Nephrology, the Affilliated Hospital of Changchun University of Chinese Medicine,Changchun,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 81374039)
- DOI：10.1007/s11655-016-2599-6
  中图分类号：
- 纸质出版日期：2018，
  
  网络出版日期：2016-7-19，
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Tong, Yq., Sun, M., Hu, Cj. et al. Changes of QT Dispersion in Hemodialysis Patients after Administrating Zhigancao Decoction (炙甘草汤)., Chin. J. Integr. Med. 24, 627–631 (2018). https://doi.org/10.1007/s11655-016-2599-6

Yan-qing Tong, Min Sun, Chun-jie Hu, et al. Changes of QT Dispersion in Hemodialysis Patients after Administrating Zhigancao Decoction (炙甘草汤)[J]. Chinese Journal of Integrative Medicine, 2018,24(8):627-631.
Tong, Yq., Sun, M., Hu, Cj. et al. Changes of QT Dispersion in Hemodialysis Patients after Administrating Zhigancao Decoction (炙甘草汤)., Chin. J. Integr. Med. 24, 627–631 (2018). https://doi.org/10.1007/s11655-016-2599-6 DOI：

Yan-qing Tong, Min Sun, Chun-jie Hu, et al. Changes of QT Dispersion in Hemodialysis Patients after Administrating Zhigancao Decoction (炙甘草汤)[J]. Chinese Journal of Integrative Medicine, 2018,24(8):627-631. DOI： 10.1007/s11655-016-2599-6.

摘要

To observe the alteration of QT dispersion (QTd) and QTc dispersion (QTcd) in hemodialysis patients after oral administration of Zhigancao Decoction (炙甘草汤

Roasted Licorice Decoction

RLD). To investigate the alteration of QTd and QTcd in 68 routine hemodialysis patients before and after hemodialysis with 12-lead electrocardiogram (ECG) after orally administrated RLD for 4 weeks. Blood was also taken for measurement of plasma electrolytes

liver function

renal function

hemoglobin (Hgb) and hematocrit (HCT). After hemodialysis

QTd and QTcd were prolonged evidently; the difference was significant between before and after hemodialysis (P<0.05). After RLD orally administrated for 4 weeks

QTd and QTcd only slightly increased after dialysis compared with pre-dialysis (P>0.05). The QTd and QTcd of the post-therapy-post-dialysis decreased significantly compared with the pre-therapy-post-dialysis (P<0.05). There were no other significant changes in other variables (post-therapy-pre-dialysis vs. pre-therapy-pre-dialysis

or post-therapy-post-dialysis vs. pre-therapy-post-dialysis;P>0.05). After therapy

the number of patients with supraventricular arrhythmia

occasional ventricular premature beat and multiple ventricular premature beat were decreased from 15 to 4

10 to 2 and 7 to 1

respectively. RLD therapy not only lowered the increased QTd and QTcd after hemodialysis

but also displayed a safety profile.

Abstract

To observe the alteration of QT dispersion (QTd) and QTc dispersion (QTcd) in hemodialysis patients after oral administration of Zhigancao Decoction (炙甘草汤

Roasted Licorice Decoction

liver function

renal function

hemoglobin (Hgb) and hematocrit (HCT). After hemodialysis

QTd and QTcd were prolonged evidently; the difference was significant between before and after hemodialysis (P<0.05). After RLD orally administrated for 4 weeks

or post-therapy-post-dialysis vs. pre-therapy-post-dialysis;P>0.05). After therapy

the number of patients with supraventricular arrhythmia

occasional ventricular premature beat and multiple ventricular premature beat were decreased from 15 to 4

10 to 2 and 7 to 1

respectively. RLD therapy not only lowered the increased QTd and QTcd after hemodialysis

but also displayed a safety profile.

关键词

chronic renal failureQT dispersionhemodialysisroasted licorice decoctionChinese Medicine

Keywords

chronic renal failureQT dispersionhemodialysisroasted licorice decoctionChinese Medicine

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