Prophylactic herbal therapy prevents experimental ascending urinary tract infection in mice

Yan-qing Tong; Min Sun; Ying Chi

doi:10.1007/s11655-016-2601-3

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Prophylactic herbal therapy prevents experimental ascending urinary tract infection in mice

OriginalPaper | Updated：2021-08-27

- Prophylactic herbal therapy prevents experimental ascending urinary tract infection in mice
- Prophylactic herbal therapy prevents experimental ascending urinary tract infection in mice
- 中国结合医学杂志（英文版） 2016年22卷第10期页码：774-777
- Affiliations：
  
  1. Department of Nephrology, the First Affilliated Hospital to Changchun University of Chinese Medicine,Changchun,China
  2. Department of Microbiology, the First Affilliated Hospital to Changchun University of Chinese Medicine,Changchun,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 81374039)
- DOI：10.1007/s11655-016-2601-3
  中图分类号：
- 纸质出版日期：2016，
  
  网络出版日期：2016-7-19，
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Tong, Yq., Sun, M. & Chi, Y. Prophylactic herbal therapy prevents experimental ascending urinary tract infection in mice., Chin. J. Integr. Med. 22, 774–777 (2016). https://doi.org/10.1007/s11655-016-2601-3

Yan-qing Tong, Min Sun, Ying Chi. Prophylactic herbal therapy prevents experimental ascending urinary tract infection in mice[J]. Chinese Journal of Integrative Medicine, 2016,22(10):774-777.
Tong, Yq., Sun, M. & Chi, Y. Prophylactic herbal therapy prevents experimental ascending urinary tract infection in mice., Chin. J. Integr. Med. 22, 774–777 (2016). https://doi.org/10.1007/s11655-016-2601-3 DOI：

Yan-qing Tong, Min Sun, Ying Chi. Prophylactic herbal therapy prevents experimental ascending urinary tract infection in mice[J]. Chinese Journal of Integrative Medicine, 2016,22(10):774-777. DOI： 10.1007/s11655-016-2601-3.

摘要

To study the preventive effect of herbal formulation on experimental murine urinary tract infection (UTI) induced by Dr Escherichia coli 11128. E. coli 11128 carrying Dr fimbriae was isolated from patients with chronic pyelonephritis. The minimal inhibitory concentration (MIC) value of herbal solution for E. coli 11128 was determined for further studies. Forty C3H/HeJ mice were divided into the herb-treated group (n=20

given Chinese herbs by gavage at an average dose of 20 g/kg body weight daily 3 days before inoculation)

and control group (n=20

given the same amount of distilled water by gavage). Three and 6 days after infection

bacteria were counted in the urine and the kidneys of the mice. Kidney histopathologic changes were evaluated. Neutrophils infiltration and accumulation were detected. The MIC value of herbal solution was 0.1 g/mL for the E. coli 11128. In herb-treated mice

there was a significant reduction in bacterial counts in urine and colonization densities of kidneys. Microscopic studies revealed signs of inflammation in kidneys. In herb-treated mice

herbal administration resulted in significantly reduced neutrophilic infiltrates (P<0.05). The semi-quantitative scores for renal lesions were significantly lower (P<0.05). Prophylactic administration of herbal formulation potentiated the effect in partially preventing experimental murine ascending UTI.

Abstract

given Chinese herbs by gavage at an average dose of 20 g/kg body weight daily 3 days before inoculation)

and control group (n=20

given the same amount of distilled water by gavage). Three and 6 days after infection

there was a significant reduction in bacterial counts in urine and colonization densities of kidneys. Microscopic studies revealed signs of inflammation in kidneys. In herb-treated mice

关键词

ascending urinary tract infectionChinese MedicineDr fimbriae

Keywords

ascending urinary tract infectionChinese MedicineDr fimbriae

references

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