Evaluation of antinociceptive and anti-inflammatory effects of aqueous extract of Armadillidium vulgare Latreille

Shen-shen Guo; Meng-yue Ren; Shuai Song; Ping Wei; Jia-bo Luo

doi:10.1007/s11655-016-2646-3

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Evaluation of antinociceptive and anti-inflammatory effects of aqueous extract of Armadillidium vulgare Latreille

OriginalPaper | Updated：2021-08-27

- Evaluation of antinociceptive and anti-inflammatory effects of aqueous extract of Armadillidium vulgare Latreille
- Evaluation of antinociceptive and anti-inflammatory effects of aqueous extract of Armadillidium vulgare Latreille
- 中国结合医学杂志（英文版） 2017年23卷第2期页码：138-145
- Affiliations：
  
  1. School of Traditional Chinese Medicine, Southern Medical University,Guangzhou,China
  2. Guangdong Province Key Laboratory of Chinese Medicine Pharmaceutics, Southern Medical University,Guangzhou,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-016-2646-3
  中图分类号：
- 纸质出版日期：2017，
  
  网络出版日期：2017-3-7，
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Guo, Ss., Ren, My., Song, S. et al. Evaluation of antinociceptive and anti-inflammatory effects of aqueous extract of Armadillidium vulgare Latreille., Chin. J. Integr. Med. 23, 138–145 (2017). https://doi.org/10.1007/s11655-016-2646-3

Shen-shen Guo, Meng-yue Ren, Shuai Song, et al. Evaluation of antinociceptive and anti-inflammatory effects of aqueous extract of Armadillidium vulgare Latreille[J]. Chinese Journal of Integrative Medicine, 2017,23(2):138-145.
Guo, Ss., Ren, My., Song, S. et al. Evaluation of antinociceptive and anti-inflammatory effects of aqueous extract of Armadillidium vulgare Latreille., Chin. J. Integr. Med. 23, 138–145 (2017). https://doi.org/10.1007/s11655-016-2646-3 DOI：

Shen-shen Guo, Meng-yue Ren, Shuai Song, et al. Evaluation of antinociceptive and anti-inflammatory effects of aqueous extract of Armadillidium vulgare Latreille[J]. Chinese Journal of Integrative Medicine, 2017,23(2):138-145. DOI： 10.1007/s11655-016-2646-3.

摘要

To assess the antinociceptive and anti-inflammatory properties of the aqueous extract of Armadillidium vulgare (AV). The antinociceptive effect of AV (400

600 and 800 mg/kg) was investigated in mice using the acetic acid-induced writhing

formalin-induced nociceptive

and hot plate tests. Phlogogen-induced paw edema using carrageenan

dextran

or compound 48/80 as phlogogen was used as inflammatory models to evaluate AV's anti-inflammatory effect. Additionally

the bioactive substances glucosamine (GLcN) and taurine in AV were determined using high-performance liquid chromatography. Oral treatment of the mice with AV (600 and 800 mg/kg) significantly reduced the number of writhes in the acetic acid-induced writhing test (P<0.01) but not the hot plate test (P>0.05). All doses tested significantly inhibited paw-withdrawal during the second phase of the formalin-induced nociceptive model (P<0.01). AV demonstrated a strong anti-inflammatory effect in all those inflammatory models (P<0.05). AV has antinociceptive and anti-inflammatory effects

providing scientific evidence of the efficacy of its traditional use in pain treatment. Furthermore

GLcN and taurine contribute

at least in part

to the anti-inflammatory activity of AV.

Abstract

To assess the antinociceptive and anti-inflammatory properties of the aqueous extract of Armadillidium vulgare (AV). The antinociceptive effect of AV (400

600 and 800 mg/kg) was investigated in mice using the acetic acid-induced writhing

formalin-induced nociceptive

and hot plate tests. Phlogogen-induced paw edema using carrageenan

dextran

or compound 48/80 as phlogogen was used as inflammatory models to evaluate AV's anti-inflammatory effect. Additionally

providing scientific evidence of the efficacy of its traditional use in pain treatment. Furthermore

GLcN and taurine contribute

at least in part

to the anti-inflammatory activity of AV.

关键词

Armadillidium vulgaremedicinal animalnociceptioninflammationglucosamine

Keywords

Armadillidium vulgaremedicinal animalnociceptioninflammationglucosamine

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