Effect of compound Zhuye Shigao Granule (复方竹叶石膏 颗粒) on acute radiation-induced esophagitis in cancer patients: A randomized controlled trial

Li-juan Wang; Jun-zhang Lu; Bo-ning Cai; Ming-wei Li; Bao-lin Qu

doi:10.1007/s11655-016-2652-5

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Effect of compound Zhuye Shigao Granule (复方竹叶石膏颗粒) on acute radiation-induced esophagitis in cancer patients: A randomized controlled trial

OriginalPaper | Updated：2021-08-27

- Effect of compound Zhuye Shigao Granule (复方竹叶石膏颗粒) on acute radiation-induced esophagitis in cancer patients: A randomized controlled trial
- Effect of compound Zhuye Shigao Granule (复方竹叶石膏颗粒) on acute radiation-induced esophagitis in cancer patients: A randomized controlled trial
- 中国结合医学杂志（英文版） 2017年23卷第2期页码：98-104
- Affiliations：
  
  1. Department of Chinese Medicine, Chinese PLA General Hospital,Beijing,China
  2. Department of Radiation Therapy, Chinese PLA General Hospital,Beijing,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 81373543) and Clinical Research Support Fund of the PLA General Hospital (No. 2013FC-ZHCG-1002)
- DOI：10.1007/s11655-016-2652-5
  中图分类号：
- 纸质出版日期：2017，
  
  网络出版日期：2016-12-29，
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Wang, Lj., Lu, Jz., Cai, Bn. et al. Effect of compound Zhuye Shigao Granule (复方竹叶石膏颗粒) on acute radiation-induced esophagitis in cancer patients: A randomized controlled trial., Chin. J. Integr. Med. 23, 98–104 (2017). https://doi.org/10.1007/s11655-016-2652-5

Li-juan Wang, Jun-zhang Lu, Bo-ning Cai, et al. Effect of compound Zhuye Shigao Granule (复方竹叶石膏颗粒) on acute radiation-induced esophagitis in cancer patients: A randomized controlled trial[J]. Chinese Journal of Integrative Medicine, 2017,23(2):98-104.
Wang, Lj., Lu, Jz., Cai, Bn. et al. Effect of compound Zhuye Shigao Granule (复方竹叶石膏颗粒) on acute radiation-induced esophagitis in cancer patients: A randomized controlled trial., Chin. J. Integr. Med. 23, 98–104 (2017). https://doi.org/10.1007/s11655-016-2652-5 DOI：

Li-juan Wang, Jun-zhang Lu, Bo-ning Cai, et al. Effect of compound Zhuye Shigao Granule (复方竹叶石膏颗粒) on acute radiation-induced esophagitis in cancer patients: A randomized controlled trial[J]. Chinese Journal of Integrative Medicine, 2017,23(2):98-104. DOI： 10.1007/s11655-016-2652-5.

摘要

To observe the efficacy and safety of the Chinese medicine (CM) Compound Zhuye Shigao Granule (复方竹叶石膏颗粒

CZSG) on acute radiation-induced esophagitis (ARIE) in cancer patients. In a blinded

randomized

Kangfuxin Solution (康复新液

KFX)-controlled

single-centre clinical trial

120 patients with lung

esophagus or mediastinal cancer were prospectively enrolled and assigned to the treatment group (60 cases) and control group (60 cases) by the random number table method. All patients received concurrent or sequential radiotherapy (2 Gy per day

5 times per week

for 4 weeks) and were treated for 4 weeks since the radiation therapy. Patients in the treatment group were given 12 mg CZSG orally

thrice daily

while patients in the control group were given 10 mL KFX orally

thrice daily. The major indicators were observed

including the incidence and grade of esophagitis

time of occurrence and duration. Minor indicators were changes of CM symptoms

weight and Karnofsky Performance Status (KPS) Scale during 4 weeks from the beginning

recorded once a week. Blood routine examination and hepatorenal function were detected at the 2nd and 4th weeks. The incidence and grade of ARIE were significantly decreased in the treatment group compared with the control group (P<0.05). CZSG appeared to significantly delay the time of ARIE occurrence and reduce the duration compared with KFX (P<0.05). The scores of CM symptoms

KPS and weight were improved significantly in the treatment group compared with the control group (P<0.05). There were no blood routine and hepatorenal function abnormal or obvious side-effects in both groups. Hemoglobin was improved and neutrophil and interleukin 6 were decreased in both groups after 4-week treatment compared with before treatment (P<0.05)

and there was no significant difference between the two groups (P>0.05). CZSG can decrease the incidence and grade of ARIE

delay the time of occurrence

reduce duration and alleviate the damage of ARIE. It is safe and effective in the prevention and cure of ARIE.

Abstract

To observe the efficacy and safety of the Chinese medicine (CM) Compound Zhuye Shigao Granule (复方竹叶石膏颗粒

CZSG) on acute radiation-induced esophagitis (ARIE) in cancer patients. In a blinded

randomized

Kangfuxin Solution (康复新液

KFX)-controlled

single-centre clinical trial

120 patients with lung

5 times per week

for 4 weeks) and were treated for 4 weeks since the radiation therapy. Patients in the treatment group were given 12 mg CZSG orally

thrice daily

while patients in the control group were given 10 mL KFX orally

thrice daily. The major indicators were observed

including the incidence and grade of esophagitis

time of occurrence and duration. Minor indicators were changes of CM symptoms

weight and Karnofsky Performance Status (KPS) Scale during 4 weeks from the beginning

and there was no significant difference between the two groups (P>0.05). CZSG can decrease the incidence and grade of ARIE

delay the time of occurrence

reduce duration and alleviate the damage of ARIE. It is safe and effective in the prevention and cure of ARIE.

关键词

Compound Zhuye Shigao Granuleacute radiation-induced esophagitisradiotherapyChinese Medicinecancer

Keywords

Compound Zhuye Shigao Granuleacute radiation-induced esophagitisradiotherapyChinese Medicinecancer

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