Effects of Shugan Jianpi Formula (疏肝健脾方) on myeloid-derived suppression cells-mediated depression breast cancer mice

Yu-tong Lu; Jie Li; Xin Qi; Ying-xia Pei; Wen-guang Shi; Hong-sheng Lin

doi:10.1007/s11655-016-2734-4

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Effects of Shugan Jianpi Formula (疏肝健脾方) on myeloid-derived suppression cells-mediated depression breast cancer mice

OriginalPaper | Updated：2021-08-27

- Effects of Shugan Jianpi Formula (疏肝健脾方) on myeloid-derived suppression cells-mediated depression breast cancer mice
- Effects of Shugan Jianpi Formula (疏肝健脾方) on myeloid-derived suppression cells-mediated depression breast cancer mice
- 中国结合医学杂志（英文版） 2017年23卷第6期页码：453-460
- Affiliations：
  
  1. Department of Oncology, Guang’anmen Hospital, China Academy of Chinese Medicine Sciences,Beijing,China
  2. Department of Oncology, Southern District of Guang’anmen Hospital, China Academy of Chinese Medicine Sciences,Beijing,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 81273946 and No. 81072802) and the National Science and Technology Major Projects for "Major New Drugs Innovation and Development" (No. 2013ZX09303301)
- DOI：10.1007/s11655-016-2734-4
  中图分类号：
- 纸质出版日期：2017，
  
  网络出版日期：2016-10-28，
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Lu, Yt., Li, J., Qi, X. et al. Effects of Shugan Jianpi Formula (疏肝健脾方) on myeloid-derived suppression cells-mediated depression breast cancer mice., Chin. J. Integr. Med. 23, 453–460 (2017). https://doi.org/10.1007/s11655-016-2734-4

Yu-tong Lu, Jie Li, Xin Qi, et al. Effects of Shugan Jianpi Formula (疏肝健脾方) on myeloid-derived suppression cells-mediated depression breast cancer mice[J]. Chinese Journal of Integrative Medicine, 2017,23(6):453-460.
Lu, Yt., Li, J., Qi, X. et al. Effects of Shugan Jianpi Formula (疏肝健脾方) on myeloid-derived suppression cells-mediated depression breast cancer mice., Chin. J. Integr. Med. 23, 453–460 (2017). https://doi.org/10.1007/s11655-016-2734-4 DOI：

Yu-tong Lu, Jie Li, Xin Qi, et al. Effects of Shugan Jianpi Formula (疏肝健脾方) on myeloid-derived suppression cells-mediated depression breast cancer mice[J]. Chinese Journal of Integrative Medicine, 2017,23(6):453-460. DOI： 10.1007/s11655-016-2734-4.

摘要

To observe the intervention effect of Shugan Jianpi Formula (疏肝健脾方

SGJPF) on a breast cancer mouse model with depression and investigate the underlying mechanism of SGJPF in preventing the development of breast cancer. The breast cancer model was induced by inoculation of breast cancer cells

the depression model was induced by chronic stress stimuli

and the depression cancer model was established by combining the two factors. The mice were divided into 7 groups: normal control

depression model

tumor model

depression tumor model

SGJPF

chemotherapy

and SGJPF+chemotherapy groups. The last 3 groups were depression breast cancer mice and treated respectively with SGJPF

chemotherapy drug gemcitabine (GEM)

and SGJPF alongside GEM. The condition of the mice was evaluated by the expression of 5-hydroxytryptamine in hippocampus after the sucrose water test and open field test

weight change

and survival time. Tumor growth was monitored with in vivo imaging. Flow cytometry was used to analyze the level of myeloid-derived suppression cell (MDSC) in the mouse spleen

T cell subsets

and the early apoptosis of CD8+ T cells. The SGJPF+GEM group had the highest inhibition rate and the longest survival time (P<0.01). The MDSC level and the apoptosis rate of CD8+ T cells was the highest in the SGJPF+GEM group (P<0.05). Depressive disorders and tumor growth could suppress the immune function of mice to different degrees

and the microenvironment in late 4T1 inflammatory breast cancer may play an important role in the pathological process. SGJYF could regulate the immune microenvironment by reducing CD8+ T lymphocyte apoptosis and tumor cell activity

increasing immune surveillance capability

and inhibiting MDSC proliferation

thus prolonging the survival time of tumor-bearing mice.

Abstract

To observe the intervention effect of Shugan Jianpi Formula (疏肝健脾方

the depression model was induced by chronic stress stimuli

and the depression cancer model was established by combining the two factors. The mice were divided into 7 groups: normal control

depression model

tumor model

depression tumor model

SGJPF

chemotherapy

and SGJPF+chemotherapy groups. The last 3 groups were depression breast cancer mice and treated respectively with SGJPF

chemotherapy drug gemcitabine (GEM)

and SGJPF alongside GEM. The condition of the mice was evaluated by the expression of 5-hydroxytryptamine in hippocampus after the sucrose water test and open field test

weight change

and survival time. Tumor growth was monitored with in vivo imaging. Flow cytometry was used to analyze the level of myeloid-derived suppression cell (MDSC) in the mouse spleen

T cell subsets

increasing immune surveillance capability

and inhibiting MDSC proliferation

thus prolonging the survival time of tumor-bearing mice.

关键词

Breast CancerShugan Jianpi FormulaChinese Medicinemyeloid-derived suppression celldepressive disordersapoptosis

Keywords

Breast CancerShugan Jianpi FormulaChinese Medicinemyeloid-derived suppression celldepressive disordersapoptosis

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