Pattern Classification of Enterovirus 71-Associated Hand, Foot, and Mouth Disease in Chinese Medicine: A Retrospective Study in 433 Cases

Yan Liu; Li-yun He; Tian-cai Wen; Shi-yan Yan; Wen-jing Bai; Bao-yan Liu

doi:10.1007/s11655-017-2420-1

Your Location：

Home >

Browse articles >

Pattern Classification of Enterovirus 71-Associated Hand, Foot, and Mouth Disease in Chinese Medicine: A Retrospective Study in 433 Cases

OriginalPaper | Updated：2021-08-27

- Pattern Classification of Enterovirus 71-Associated Hand, Foot, and Mouth Disease in Chinese Medicine: A Retrospective Study in 433 Cases
- Pattern Classification of Enterovirus 71-Associated Hand, Foot, and Mouth Disease in Chinese Medicine: A Retrospective Study in 433 Cases
- 中国结合医学杂志（英文版） 2018年24卷第2期页码：87-93
- Affiliations：
  
  Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences,Beijing,China
- Author bio：
- Funds：
  
  Supported by the Nation Health and Family Planning Commission of China (No. 2012ZX10005009), Fundamental Research Funds for the Central Public Welfare Research Institutes (No. Z0474) and National Natural Science Foundation of China (No. 81503679)
- DOI：10.1007/s11655-017-2420-1
  中图分类号：
- 纸质出版日期：2018，
  
  网络出版日期：2017-10-17，
Scan for full text
Liu, Y., He, Ly., Wen, Tc. et al. Pattern Classification of Enterovirus 71-Associated Hand, Foot, and Mouth Disease in Chinese Medicine: A Retrospective Study in 433 Cases., Chin. J. Integr. Med. 24, 87–93 (2018). https://doi.org/10.1007/s11655-017-2420-1

Yan Liu, Li-yun He, Tian-cai Wen, et al. Pattern Classification of Enterovirus 71-Associated Hand, Foot, and Mouth Disease in Chinese Medicine: A Retrospective Study in 433 Cases[J]. Chinese Journal of Integrative Medicine, 2018,24(2):87-93.
Liu, Y., He, Ly., Wen, Tc. et al. Pattern Classification of Enterovirus 71-Associated Hand, Foot, and Mouth Disease in Chinese Medicine: A Retrospective Study in 433 Cases., Chin. J. Integr. Med. 24, 87–93 (2018). https://doi.org/10.1007/s11655-017-2420-1 DOI：

Yan Liu, Li-yun He, Tian-cai Wen, et al. Pattern Classification of Enterovirus 71-Associated Hand, Foot, and Mouth Disease in Chinese Medicine: A Retrospective Study in 433 Cases[J]. Chinese Journal of Integrative Medicine, 2018,24(2):87-93. DOI： 10.1007/s11655-017-2420-1.

摘要

To determine whether patterns of enterovirus 71 (EV71)-associated hand

foot

and mouth disease (HFMD) were classified based on symptoms and signs

and explore whether individual characteristics were correlated with membership in particular pattern. Symptom-based latent class analysis (LCA) was used to determine whether patterns of EV71-HFMD existed in a sample of 433 cases from a clinical data warehouse system. Logistic regression was then performed to explore whether demographic

and laboratory data were associated with pattern membership. LCA demonstrated a two-subgroup solution with an optimal fit

deduced according to the Bayesian Information Criterion minima. Hot pattern (59.1% of all patients) was characterized by a very high fever and high endorsement rates for classical HFMD symptoms (i.e.

rash on the extremities

blisters

and oral mucosa lesions). Non-hot pattern (40.9% of all patients) was characterized by classical HFMD symptoms. The multiple logistic regression results suggest that white blood cell counts and aspartate transaminase were positively correlated with the hot pattern (adjust odds ratio=1.07

95% confidence interval: 1.006–1.115; adjust odds ratio=1.051

95% confidence interval: 1.019–1.084; respectively). LCA on reported symptoms and signs in a retrospective study allowed different subgroups with meaningful clinical correlates to be defined. These findings provide evidence for targeted prevention and treatment interventions.

Abstract

To determine whether patterns of enterovirus 71 (EV71)-associated hand

foot

and mouth disease (HFMD) were classified based on symptoms and signs

and laboratory data were associated with pattern membership. LCA demonstrated a two-subgroup solution with an optimal fit

deduced according to the Bayesian Information Criterion minima. Hot pattern (59.1% of all patients) was characterized by a very high fever and high endorsement rates for classical HFMD symptoms (i.e.

rash on the extremities

blisters

95% confidence interval: 1.006–1.115; adjust odds ratio=1.051

关键词

handfoot and mouth diseasepattern classificationenterovirus AhumanChinese Medicine

Keywords

handfoot and mouth diseasepattern classificationenterovirus AhumanChinese Medicine

references

Xing W, Liao Q, Viboud C, Zhang J, Sun J, Wu JT, et al. Hand, foot, and mouth disease in China, 2008-12: an epidemiological study. Lancet Infect Dis 2014;14:308–318.

Ooi MH, Wong SC, Lewthwaite P, Cardosa MJ, Solomon T. Clinical features, diagnosis, and management of enterovirus 71. Lancet Neurol 2010;9:1097–1105.

Li X, Zhang X, Ding J, Xu Y, Wei D, Tian Y, et al. Comparison between Chinese herbal medicines and conventional therapy in the treatment of severe hand, foot, and mouth disease: a randomized controlled trial. Evid Based Complement Alternat Med 2014;2014:140764.

He LY, Zhang GL, Yan SY, Liu Y, Zhao CS, Wang XL, et al. A double-blind comparative study of Chinese herbal medicine Jinlian Qingre Effervescent Tablets in combination with conventional therapy for the treatment of uncomplicated hand, foot, and mouth disease. Eur J Clin Microbiol Infect Dis 2014;33:1429–1437.

HCao ZL, Steinmann YM, Luo JL. Chinese herbal medicines for treatment of hand, foot and mouth disease: a systematic review of randomized clinical trials. Eur J Integr Med 2012.

Su SB, Jia W, Lu A, Li S. Evidence-based Zheng: a traditional Chinese medicine syndrome 2013. Evid Based Complement Alternat Med 2014;2014:484201.

Wang M, Chen G, Lu C, Xiao C, Li L, Niu X, et al. Rheumatoid arthritis with deficiency pattern in traditional Chinese medicine shows correlation with cold and hot patterns in gene expression profiles. Evid Based Complement Alternat Med 2013;2013:248650.

Lanza ST, Rhoades BL. Latent class analysis: an alternative perspective on subgroup analysis in prevention and treatment. Prev Sci 2013;14:157–168.

Schochet PZ. An approach for addressing the multiple testing problem in social policy impact evaluations. Eval Rev 2009;33:539–567.

The State Administration of Traditional Chinese Medicine (China). The industry of traditional Chinese medicine scientific research special project plan in 2009. [http://www.satcm.gov.cn/web2010/zhengwugongkai/kejiguanli/ keyanguanli/2010-10-11/10350.html]

Zhang GL, Li ZG, Liu J. Clinical research progress of traditional Chinese medicine treatment for hand, foot and mouth disease. Clin J Tradit Chin Med (Chin) 2009;21:569–571.

The Ministry of Health of the People’s Republic of China. Guideline for the diagnosis and treatment of hand foot and mouth disease; 2010 ed. [http://www.moh.gov.cn/mohyzs/ s3586/201004/46884.shtml]

Li Y, Zhu R, Qian Y, Deng J. The characteristics of blood glucose and WBC counts in peripheral blood of cases of hand foot and mouth disease in China: a systematic review. PLoS One 2012;7:e29003.

Goodman LA. Exploratory latent structure analysis using both identifiable and unidentifiable models. Biometrika 1974;61:215–231.

Nylund KL, Asparouhov T, Muthén BO. Deciding on the number of classes in latent class analysis and growth mixture modeling: A Monte Carlo simulation study. Structural equation modeling 2007;14:535–569.

Dziak STL, Xu S. Lca Bootstrap SAS macro users’ guide (version 1.1. 0). University Park: The Methodology Center, Penn State. 2011. 2012.

Lanza ST, Bray BC. Transitions in drug use among highrisk women: an application of latent class and latent transition analysis. Adv Appl Stat Sci 2010;3:203–235.

Cleveland MJ, Collins LM, Lanza ST, Greenberg MT, Feinberg ME. Does individual risk moderate the effect of contextual-level protective factors? A latent class analysis of substance use. J Prev Interv Community 2010;38:213–228.

Lanza ST, Collins LM, Lemmon DR, Schafer JL. PROC LCA: a SAS procedure for latent class analysis. Struct Equ Modeling 2007;14: 671–694.

Chan KP, Goh KT, Chong CY, Teo ES, Lau G, Ling AE. Epidemic hand, foot and mouth disease caused by human enterovirus 71, Singapore. Emerg Infect Dis 2003;9:78–85.

Chen KT, Chang HL, Wang ST, Cheng YT, Yang JY. Epidemiologic features of hand-foot-mouth disease and herpangina caused by enterovirus 71 in Taiwan, 1998-2005. Pediatrics 2007;120:e244–252.

Tu PV, Thao NT, Perera D, Huu TK, Tien NT, Thuong TC, et al. Epidemiologic and virologic investigation of hand, foot, and mouth disease, southern Vietnam, 2005. Emerg Infect Dis 2007;13:1733–1741.

WHO Regional Office for the Western Pacific. A guide to clinical management and public health response for hand, foot and mouth disease. [http://www.wpro.who.int/publications/docs/GuidancefortheclinicalmanagementofHF MD.pdf.]

Zhou X, Menche J, Barabasi AL, Sharma A. Human symptoms-disease network. Nat Commun 2014;5:4212.

Cui MM, Li YN, Ma HB. Hand, foot and mouth disease clinical syndrome distribution regularity and TCM syndrome type and number of body temperature, skin rashes, main laboratory examination. China J Tradit Chin Med Pharm (Chin) 2014:3733-3736.

Li W, Teng G, Tong H, Jiao Y, Zhang T, Chen H, et al. Study on risk factors for severe hand, foot and mouth disease in China. PLoS One 2014;9:e87603.

Shin BC, Kim S, Cho YH. Syndrome pattern and its application in parallel randomized controlled trials. Chin J Integr Med 2013;19:163–171.

Liu J, Zhang GL, Huang GQ, Li L, Li CP, Wang M, et al. Therapeutic effect of Jinzhen oral liquid for hand foot and mouth disease: a randomized, multi-center, double-blind, placebo-controlled trial. PLoS One 2014;9:e94466.

FULL TEXT LINK

More>

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Effect of integrated Chinese and Western medicine therapy on severe hand, foot and mouth disease: A prospective, randomized, controlled trial

Future view and development of immunology: Exploring the immunology based on Chinese medicine and culture

Cost-effectiveness analysis of combined Chinese medicine and Western medicine for ischemic stroke patients

Objective tongue inspection on 142 liver cancer patients with damp-heat syndrome

Effect of Ermiao Recipe (二妙方) with medicinal guide Angelicae Pubescentis Radix on promoting the homing of bone marrow stem cells to treat cartilage damage in osteoarthritis rats