Effect of Miscanthus sinensis var. purpurascens Flower Extract on Proliferation and Molecular Regulation in Human Dermal Papilla Cells and Stressed C57BL/6 Mice

Gi Hee Jeong; William A. Boisvert; Mei-zhu Xi; Yi-lin Zhang; Young-Bin Choi; Sunghun Cho; Sanghyun Lee; Changsun Choi; Bog-Hieu Lee

doi:10.1007/s11655-017-2755-7

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Effect of Miscanthus sinensis var. purpurascens Flower Extract on Proliferation and Molecular Regulation in Human Dermal Papilla Cells and Stressed C57BL/6 Mice

OriginalPaper | Updated：2021-08-27

- Effect of Miscanthus sinensis var. purpurascens Flower Extract on Proliferation and Molecular Regulation in Human Dermal Papilla Cells and Stressed C57BL/6 Mice
- Effect of Miscanthus sinensis var. purpurascens Flower Extract on Proliferation and Molecular Regulation in Human Dermal Papilla Cells and Stressed C57BL/6 Mice
- 中国结合医学杂志（英文版） 2018年24卷第8期页码：591-599
- Affiliations：
  
  1. Department of Food and Nutrition, College of Biotechnology and Natural Resources, Chung-Ang University, Anseong, Republic of Korea
  2. Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii,Honolulu,USA
  3. Department of Integrative Plant Science, College of Biotechnology and Natural Resources, Chung-Ang University, Anseong, Republic of Korea
- Author bio：
- Funds：
  
  Supported by Business for Cooperative R&D between Industry, Academy, and Research Institute funded Korea Small and Medium Business Administration (No. C0142798) in 2013;and by the Chung-Ang University Research Grants in 2015
- DOI：10.1007/s11655-017-2755-7
  中图分类号：
- 纸质出版日期：2018，
  
  网络出版日期：2017-5-11，
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Jeong, G.H., Boisvert, W.A., Xi, Mz. et al. Effect of Miscanthus sinensis var. purpurascens Flower Extract on Proliferation and Molecular Regulation in Human Dermal Papilla Cells and Stressed C57BL/6 Mice., Chin. J. Integr. Med. 24, 591–599 (2018). https://doi.org/10.1007/s11655-017-2755-7

Gi Hee Jeong, William A. Boisvert, Mei-zhu Xi, et al. Effect of Miscanthus sinensis var. purpurascens Flower Extract on Proliferation and Molecular Regulation in Human Dermal Papilla Cells and Stressed C57BL/6 Mice[J]. Chinese Journal of Integrative Medicine, 2018,24(8):591-599.
Jeong, G.H., Boisvert, W.A., Xi, Mz. et al. Effect of Miscanthus sinensis var. purpurascens Flower Extract on Proliferation and Molecular Regulation in Human Dermal Papilla Cells and Stressed C57BL/6 Mice., Chin. J. Integr. Med. 24, 591–599 (2018). https://doi.org/10.1007/s11655-017-2755-7 DOI：

Gi Hee Jeong, William A. Boisvert, Mei-zhu Xi, et al. Effect of Miscanthus sinensis var. purpurascens Flower Extract on Proliferation and Molecular Regulation in Human Dermal Papilla Cells and Stressed C57BL/6 Mice[J]. Chinese Journal of Integrative Medicine, 2018,24(8):591-599. DOI： 10.1007/s11655-017-2755-7.

摘要

To investigate the hair growth-promoting effect of Miscanthus sinensis var. purpurascens (MSP) flower extracton on in vitro and in vivo models. MSP flower extract was extracted in 99.9% methanol and applied to examine the proliferation of human dermal papilla cells (hDPCs) in vitro at the dose of 3.92–62.50 μg/mL and hair growth of C57BL/6 mice in vivo at the dose of 1000 μg/mL. The expression of transforming growth factor β1 (TGF-β1)

hepatocyte growth factor (HGF)

β-catenin

substance P was measured by relative quantitative realtime polymerase chain reaction. Histopathological and immunohistochemical analysis were performed. MSP (7.81 μg/mL) down-regulated TGF-β1 and up-regulated HGF and β-catenin in hDPCs (P<0.01). MSP (1000 μg/mL)-treated mice showed the earlier transition of hair follicles from the telogen to the anagen phase. The number of mast cells was lower in the MSP-treated mice than in other groups (P<0.05 vs. NCS group). Substance P and TGF-β1 were expressed in hair follicles and skin of the MSP group lower than that in negative control. Stem cell factor in hair follicles was up-regulated in the MSP-treated mice (P<0.01). The MSP flower extract may have hair growth-promotion activities.

Abstract

hepatocyte growth factor (HGF)

β-catenin

关键词

Miscanthus sinensis var. purpurascens flower extracthair growthhuman hair dermal papilla cellhepatocyte growth factortransforming growth factor β1

Keywords

Miscanthus sinensis var. purpurascens flower extracthair growthhuman hair dermal papilla cellhepatocyte growth factortransforming growth factor β1

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